Biography

Shawn C. Burgess obtained his PhD in Chemistry in 2000 from the University of Texas at Dallas for research on using carbon-13 tracers and nuclear magnetic resonance (NMR) to examine metabolic flux. From 2000-2003 he was a postdoctoral research scientist in the Department of Radiology at UT Southwestern where he studied substrate metabolism in β-cell and liver using tracer approaches.

In the Center for Human Nutrition, the Burgess Lab uses stable isotope tracers, NMR and mass spectrometry to study how metabolic flux is regulated by molecular physiology and altered by disease or pharmacology.  His lab focuses on pathways of oxidative and biosynthetic metabolism in the context of obesity, insulin resistance and diabetes.  They seek to understand how metabolic mechanisms contribute to pathologies of disease such as steatosis, oxidative stress and inflammation.    

Education

Graduate School
University of Texas at Dallas (1997), Chemistry
Graduate School
University of Texas at Dallas (2000), Chemistry

Research Interest

  • Biological NMR and MS
  • In Vivo and Ex Vivo isotope tracer techniques
  • Intermediary metabolism of obesity and diabetes
  • Metabolic mechanisms of disease
  • Regulation of carbohydrate and lipid metabolism in liver

Publications

Featured Publications LegendFeatured Publications

Real-Time Detection of Hepatic Gluconeogenic and Glycogenolytic States Using Hyperpolarized [2-13C]Dihydroxyacetone.
Moreno KX, Satapati S, DeBerardinis RJ, Burgess SC, Malloy CR, Merritt ME J. Biol. Chem. 2014 Oct
Propionate stimulates pyruvate oxidation in the presence of acetate.
Purmal C, Kucejova B, Sherry AD, Burgess SC, Malloy CR, Merritt ME Am. J. Physiol. Heart Circ. Physiol. 2014 Oct 307 8 H1134-41
Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion.
Vigueira PA, McCommis KS, Schweitzer GG, Remedi MS, Chambers KT, Fu X, McDonald WG, Cole SL, Colca JR, Kletzien RF, Burgess SC, Finck BN Cell Rep 2014 Jun 7 6 2042-53
A Noncanonical, GSK3-Independent Pathway Controls Postprandial Hepatic Glycogen Deposition.
Wan M, Leavens KF, Hunter RW, Koren S, von Wilamowitz-Moellendorff A, Lu M, Satapati S, Chu Q, Sakamoto K, Burgess SC, Birnbaum MJ Cell Metab. 2013 Jul 18 1 99-105
Metabolomics, Stable Isotopes, and A-ß+ Ketosis-Prone Diabetes.
Ramos-Roman MA, Burgess SC, Browning JD Diabetes 2013 Mar 62 3 682-4
Weight-Independent Effects of Roux-en-Y Gastric Bypass on Glucose Homeostasis via Melanocortin-4 Receptors in Mice and Humans.
Zechner JF, Mirshahi UL, Satapati S, Berglund ED, Rossi J, Scott MM, Still CD, Gerhard GS, Burgess SC, Mirshahi T, Aguirre V Gastroenterology 2013 Mar 144 3 580-590.e7
Use of (2)H(2)O for estimating rates of gluconeogenesis: determination and correction of error due to transaldolase exchange.
Browning JD, Burgess SC Am. J. Physiol. Endocrinol. Metab. 2012 Dec 303 11 E1304-12
Metabolic manifestations of insulin deficiency do not occur without glucagon action.
Lee Y, Berglund ED, Wang MY, Fu X, Yu X, Charron MJ, Burgess SC, Unger RH Proc. Natl. Acad. Sci. U.S.A. 2012 Sep 109 37 14972-6
Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding.
Chambers KT, Chen Z, Crawford PA, Fu X, Burgess SC, Lai L, Leone TC, Kelly DP, Finck BN PLoS ONE 2012 7 12 e52645
Noninvasive MRI of ß-cell function using a Zn2+-responsive contrast agent.
Lubag AJ, De Leon-Rodriguez LM, Burgess SC, Sherry AD Proc. Natl. Acad. Sci. U.S.A. 2011 Nov 108 45 18400-5

Honors & Awards

  • Daryl K. Granner Lectureship
    (2016)
  • Robert A. Welch Foundation Research Grant Award
    (2013)
  • ADA Basic Science Award
    (2009)
  • American Diabetes Junior Faculty Award
    (2005)

Professional Associations/Affiliations

  • American Diabetes Association (2003)
  • American Chemical Society (1994)
  • International Society for Magnetic Resonance in Medicine