Biography

Shawn C. Burgess obtained his PhD in Chemistry in 2000 from the University of Texas at Dallas for research on using carbon-13 tracers and nuclear magnetic resonance (NMR) to examine metabolic flux. From 2000-2003 he was a postdoctoral research scientist in the Department of Radiology at UT Southwestern where he studied substrate metabolism in β-cell and liver using tracer approaches.

In the Center for Human Nutrition, the Burgess Lab uses stable isotope tracers, NMR and mass spectrometry to study how metabolic flux is regulated by molecular physiology and altered by disease or pharmacology.  His lab focuses on pathways of oxidative and biosynthetic metabolism in the context of obesity, insulin resistance and diabetes.  They seek to understand how metabolic mechanisms contribute to pathologies of disease such as steatosis, oxidative stress and inflammation.    

Education

Graduate School
University of Texas at Dallas (1997), Chemistry
Graduate School
University of Texas at Dallas (2000), Chemistry

Research Interest

  • Biological NMR and MS
  • In Vivo and Ex Vivo isotope tracer techniques
  • Intermediary metabolism of obesity and diabetes
  • Metabolic mechanisms of disease
  • Regulation of carbohydrate and lipid metabolism in liver

Publications

Featured Publications LegendFeatured Publications

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
Kim CW, Addy C, Kusunoki J, Anderson NN, Deja S, Fu X, Burgess SC, Li C, Ruddy M, Chakravarthy M, Previs S, Milstein S, Fitzgerald K, Kelley DE, Horton JD Cell Metab. 2017 Sep 26 3 576
Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
Kim CW, Addy C, Kusunoki J, Anderson NN, Deja S, Fu X, Burgess SC, Li C, Ruddy M, Chakravarthy M, Previs S, Milstein S, Fitzgerald K, Kelley DE, Horton JD Cell Metab. 2017 Aug 26 2 394-406.e6
A Comprehensive Analysis of Myocardial Substrate Preference Emphasizes the Need For a Synchronized Fluxomic/Metabolomic Research Design.
Ragavan M, Kirpich A, Fu X, Burgess SC, McIntyre LM, Merritt ME Am. J. Physiol. Heart Circ. Physiol. 2017 Apr ajpheart.00016.2017
Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high fat diet induced hepatic steatosis.
Morris EM, Meers GM, Koch LG, Britton SL, Fletcher JA, Shankar K, Fu X, Burgess SC, Ibdah JA, Rector RS, Thyfault JP Am. J. Physiol. Endocrinol. Metab. 2016 Sep ajpendo.00178.2016
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC J. Clin. Invest. 2016 Apr 126 4 1605
A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism.
Amoasii L, Holland W, Sanchez-Ortiz E, Baskin KK, Pearson M, Burgess SC, Nelson BR, Bassel-Duby R, Olson EN Genes Dev. 2016 Feb 30 4 434-46
Production of hyperpolarized (13)CO2 from [1-(13)C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production.
Moreno KX, Moore CL, Burgess SC, Sherry AD, Malloy CR, Merritt ME Metabolomics 2015 Oct 11 5 1144-1156
Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis.
Gray LR, Sultana MR, Rauckhorst AJ, Oonthonpan L, Tompkins SC, Sharma A, Fu X, Miao R, Pewa AD, Brown KS, Lane EE, Dohlman A, Zepeda-Orozco D, Xie J, Rutter J, Norris AW, Cox JE, Burgess SC, Potthoff MJ, Taylor EB Cell Metab. 2015 Sep
A roadmap for interpreting (13)C metabolite labeling patterns from cells.
Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM Curr. Opin. Biotechnol. 2015 Feb 34C 189-201
MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver.
Baskin KK, Grueter CE, Kusminski CM, Holland WL, Bookout AL, Satapati S, Kong YM, Burgess SC, Malloy CR, Scherer PE, Newgard CB, Bassel-Duby R, Olson EN EMBO Mol Med 2014 Nov

Honors & Awards

  • Daryl K. Granner Lectureship
    (2016)
  • Robert A. Welch Foundation Research Grant Award
    (2013)
  • ADA Basic Science Award
    (2009)
  • American Diabetes Junior Faculty Award
    (2005)

Professional Associations/Affiliations

  • American Diabetes Association (2003)
  • American Chemical Society (1994)
  • International Society for Magnetic Resonance in Medicine