Shawn C. Burgess obtained his PhD in Chemistry in 2000 from the University of Texas at Dallas for research on using carbon-13 tracers and nuclear magnetic resonance (NMR) to examine metabolic flux. From 2000-2003 he was a postdoctoral research scientist in the Department of Radiology at UT Southwestern where he studied substrate metabolism in β-cell and liver using tracer approaches.
In the Center for Human Nutrition, the Burgess Lab uses stable isotope tracers, NMR and mass spectrometry to study how metabolic flux is regulated by molecular physiology and altered by disease or pharmacology. His lab focuses on pathways of oxidative and biosynthetic metabolism in the context of obesity, insulin resistance and diabetes. They seek to understand how metabolic mechanisms contribute to pathologies of disease such as steatosis, oxidative stress and inflammation.
- Graduate School
- University of Texas at Dallas (1997), Chemistry
- Graduate School
- University of Texas at Dallas (2000), Chemistry
- Biological NMR and MS
- In Vivo and Ex Vivo isotope tracer techniques
- Intermediary metabolism of obesity and diabetes
- Metabolic mechanisms of disease
- Regulation of carbohydrate and lipid metabolism in liver
- Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver.
- Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA Cell Metab. 2007 Apr 5 4 313-20
- Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR.
- Hausler N, Browning J, Merritt M, Storey C, Milde A, Jeffrey FM, Sherry AD, Malloy CR, Burgess SC Biochem. J. 2006 Mar 394 Pt 2 465-73
- A low-carbohydrate diet rapidly and dramatically reduces intrahepatic triglyceride content. Hepatology
- Browning JD, Davis J, Saboorian MH, and Burgess SC Hepatology 2006 44 487-488
- Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation
- Pengxiang She, Shawn C. Burgess, Masakazu Shiota, Paul Flakoll, E Patrick Donahue, Craig R Malloy, A Dean Sherry, and Mark A Magnuson Diabetes 2003 52 1649-1654
- Fatty Acid Desaturation Gets a NAD+ Reputation.
- Lutkewitte AJ, Burgess SC, Finck BN, Cell Metab. 2019 Apr 29 4 790-792
- A Novel Inhibitor of Pyruvate Dehydrogenase Kinase Stimulates Myocardial Carbohydrate Oxidation in Diet-Induced Obesity.
- Wu CY, Satapati S, Gui W, Wynn RM, Sharma G, Lou M, Qi X, Burgess SC, Malloy C, Khemtong C, Sherry AD, Chuang D, Merritt ME J. Biol. Chem. 2018 May
- Cytosolic Phosphoenolpyruvate Carboxykinase as a Cataplerotic Pathway in the Small Intestine.
- Potts A, Uchida A, Deja S, Berglund ED, Kucejova B, Duarte JAG, Fu X, Browning JD, Magnuson MA, Burgess SC Am. J. Physiol. Gastrointest. Liver Physiol. 2018 Apr
- Roux-en-Y Gastric Bypass Compared to Equivalent Diet Restriction: Mechanistic Insights into Diabetes Remission.
- Pop LM, Mari A, Zhao TJ, Mitchell L, Burgess S, Li X, Adams-Huet B, Lingvay I Diabetes Obes Metab 2018 Mar
- FGF19, FGF21, and an FGFR1/ß-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia.
- Lan T, Morgan DA, Rahmouni K, Sonoda J, Fu X, Burgess SC, Holland WL, Kliewer SA, Mangelsdorf DJ Cell Metab. 2017 Oct
- The NQO1 bioactivatable drug, ß-Lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.
- Silvers MA, Deja S, Singh N, Egnatchik RA, Sudderth J, Luo X, Beg MS, Burgess SC, DeBerardinis RJ, Boothman DA, Merritt ME J. Biol. Chem. 2017 Sep
Honors & Awards
- Daryl K. Granner Lectureship
- Robert A. Welch Foundation Research Grant Award
- ADA Basic Science Award
- American Diabetes Junior Faculty Award
- American Diabetes Association (2003)
- American Chemical Society (1994)
- International Society for Magnetic Resonance in Medicine