Shawn C. Burgess obtained his PhD in Chemistry in 2000 from the University of Texas at Dallas for research on using carbon-13 tracers and nuclear magnetic resonance (NMR) to examine metabolic flux. From 2000-2003 he was a postdoctoral research scientist in the Department of Radiology at UT Southwestern where he studied substrate metabolism in β-cell and liver using tracer approaches.
In the Center for Human Nutrition, the Burgess Lab uses stable isotope tracers, NMR and mass spectrometry to study how metabolic flux is regulated by molecular physiology, altered by disease or pharmacology. The lab focuses on pathways of oxidative and biosynthetic metabolism in the context of obesity, insulin resistance and diabetes. We seek to understand how metabolic mechanisms contribute to pathologies of disease such as steatosis, oxidative stress and inflammation.
- Graduate School
- University of Texas at Dallas (1997), Chemistry
- Graduate School
- University of Texas at Dallas (2000), Chemistry
- Biological NMR and MS
- In Vivo and Ex Vivo isotope tracer techniques
- Intermediary metabolism of obesity and diabetes
- Metabolic mechanisms of disease
- Regulation of carbohydrate and lipid metabolism in liver
- Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity.
- Kucejova B, Duarte J, Satapati S, Fu X, Ilkayeva O, Newgard CB, Brugarolas J, Burgess SC Cell Rep 2016 Jun
- Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
- Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC J. Clin. Invest. 2015 Dec 125 12 4447-4462
- Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.
- McCommis KS, Chen Z, Fu X, McDonald WG, Colca JR, Kletzien RF, Burgess SC, Finck BN Cell Metab. 2015 Sep
- Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate.
- Burgess SC, Merritt ME, Jones JG, Browning JD, Sherry AD, Malloy CR Nat. Med. 2015 Feb 21 2 108-9
- PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis.
- Méndez-Lucas A, Duarte JA, Sunny NE, Satapati S, He T, Fu X, Bermúdez J, Burgess SC, Perales JC J. Hepatol. 2013 Mar
- Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.
- Potthoff MJ, Potts A, He T, Duarte JA, Taussig R, Mangelsdorf DJ, Kliewer SA, Burgess SC Am. J. Physiol. Gastrointest. Liver Physiol. 2013 Feb 304 4 G371-80
- Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.
- Satapati S, Sunny NE, Kucejova B, Fu X, He TT, Méndez-Lucas A, Shelton JM, Perales JC, Browning JD, Burgess SC J. Lipid Res. 2012 Jun 53 6 1080-92
- Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease.
- Sunny NE, Parks EJ, Browning JD, Burgess SC Cell Metab. 2011 Dec 14 6 804-10
- Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance.
- Merritt ME, Harrison C, Sherry AD, Malloy CR, Burgess SC Proc. Natl. Acad. Sci. U.S.A. 2011 Nov 108 47 19084-9
- FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.
- Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, Goetz R, Mohammadi M, Finck BN, Mangelsdorf DJ, Kliewer SA, Burgess SC Proc. Natl. Acad. Sci. U.S.A. 2009 Jun 106 26 10853-8
Honors & Awards
- Robert A. Welch Foundation Research Grant Award
- ADA Basic Science Award
- American Diabetes Junior Faculty Award
- American Chemical Society 1994-2000
- American Diabetes Association 2003-
- International Society for Magnetic Resonance in Medicine