Shawn C. Burgess obtained his PhD in Chemistry in 2000 from the University of Texas at Dallas for research on using carbon-13 tracers and nuclear magnetic resonance (NMR) to examine metabolic flux. From 2000-2003 he was a postdoctoral research scientist in the Department of Radiology at UT Southwestern where he studied substrate metabolism in β-cell and liver using tracer approaches.
In the Center for Human Nutrition, the Burgess Lab uses stable isotope tracers, NMR and mass spectrometry to study how metabolic flux is regulated by molecular physiology and altered by disease or pharmacology. His lab focuses on pathways of oxidative and biosynthetic metabolism in the context of obesity, insulin resistance and diabetes. They seek to understand how metabolic mechanisms contribute to pathologies of disease such as steatosis, oxidative stress and inflammation.
- Graduate School
- University of Texas at Dallas (1997), Chemistry
- Graduate School
- University of Texas at Dallas (2000), Chemistry
- Biological NMR and MS
- In Vivo and Ex Vivo isotope tracer techniques
- Intermediary metabolism of obesity and diabetes
- Metabolic mechanisms of disease
- Regulation of carbohydrate and lipid metabolism in liver
- Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver.
- Fletcher JA, Deja S, Satapati S, Fu X, Burgess SC, Browning JD, JCI Insight 2019 Apr 5
- Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.
- Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC, Cell Metab. 2019 Apr
- Targeted Determination of Tissue Energy Status by LC-MS/MS.
- Fu X, Deja S, Kucejova B, Duarte JAG, McDonald JG, Burgess SC, Anal. Chem. 2019 Apr
- The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity.
- Rauckhorst AJ, Gray LR, Sheldon RD, Fu X, Pewa AD, Feddersen CR, Dupuy AJ, Gibson-Corley KN, Cox JE, Burgess SC, Taylor EB Mol Metab 2017 Nov 6 11 1468-1479
- Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis.
- Morris EM, McCoin CS, Allen JA, Gastecki ML, Koch LG, Britton SL, Fletcher JA, Fu X, Ding WX, Burgess SC, Rector RS, Thyfault JP J. Physiol. (Lond.) 2017 May
- Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity.
- Kucejova B, Duarte J, Satapati S, Fu X, Ilkayeva O, Newgard CB, Brugarolas J, Burgess SC Cell Rep 2016 Jun
- Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
- Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC J. Clin. Invest. 2015 Dec 125 12 4447-4462
- Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.
- McCommis KS, Chen Z, Fu X, McDonald WG, Colca JR, Kletzien RF, Burgess SC, Finck BN Cell Metab. 2015 Sep
- Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate.
- Burgess SC, Merritt ME, Jones JG, Browning JD, Sherry AD, Malloy CR Nat. Med. 2015 Feb 21 2 108-9
- A HFD suppresses de novo lipogenesis and desaturation, but not elongation and triglyceride synthesis in mice.
- Duarte JA, Carvalho F, Pearson M, Horton JD, Browning JD, Jones JG, Burgess SC J. Lipid Res. 2014 Sep
Honors & Awards
- Daryl K. Granner Lectureship
- Robert A. Welch Foundation Research Grant Award
- ADA Basic Science Award
- American Diabetes Junior Faculty Award
- American Chemical Society (1994)
- American Diabetes Association (2003)
- International Society for Magnetic Resonance in Medicine