Shawn Burgess, Ph.D. Professor Endowed Title The Dr. Robert C. and Veronica Atkins Chair in Obesity and Diabetes Research School Medical School Department Center for Human Nutrition | Pharmacology Graduate Programs Biomedical Engineering Biography Shawn C. Burgess obtained his PhD in Chemistry in 2000 from the University of Texas at Dallas for research on using carbon-13 tracers and nuclear magnetic resonance (NMR) to examine metabolic flux. From 2000-2003 he was a postdoctoral research scientist in the Department of Radiology at UT Southwestern where he studied substrate metabolism in β-cell and liver using tracer approaches. In the Center for Human Nutrition, the Burgess Lab uses stable isotope tracers, NMR and mass spectrometry to study how metabolic flux is regulated by molecular physiology and altered by disease or pharmacology. His lab focuses on pathways of oxidative and biosynthetic metabolism in the context of obesity, insulin resistance and diabetes. They seek to understand how metabolic mechanisms contribute to pathologies of disease such as steatosis, oxidative stress and inflammation. Education Graduate School University of Texas at Dallas (1997), Chemistry Graduate School University of Texas at Dallas (2000), Chemistry Research Interest Biological NMR and MS In Vivo and Ex Vivo isotope tracer techniques Intermediary metabolism of obesity and diabetes Metabolic mechanisms of disease Regulation of carbohydrate and lipid metabolism in liver Publications Featured Publications Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability. Deja S, Fletcher JA, Kim CW, Kucejova B, Fu X, Mizerska M, Villegas M, Pudelko-Malik N, Browder N, Inigo-Vollmer M, Menezes CJ, Mishra P, Berglund ED, Browning JD, Thyfault JP, Young JD, Horton JD, Burgess SC, Cell Metab 2024 Mar Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver. Fu X, Fletcher JA, Deja S, Inigo-Vollmer M, Burgess SC, Browning JD, J Clin Invest 2023 May 133 9 Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice. Rome FI, Shobert GL, Voigt WC, Stagg DB, Puchalska P, Burgess SC, Crawford PA, Hughey CC, Am J Physiol Endocrinol Metab 2023 Jan 324 1 E9-E23 Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver. Fletcher JA, Deja S, Satapati S, Fu X, Burgess SC, Browning JD, JCI Insight 2019 Apr 5 Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC, Cell Metab. 2019 Apr Targeted Determination of Tissue Energy Status by LC-MS/MS. Fu X, Deja S, Kucejova B, Duarte JAG, McDonald JG, Burgess SC, Anal. Chem. 2019 Apr The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Rauckhorst AJ, Gray LR, Sheldon RD, Fu X, Pewa AD, Feddersen CR, Dupuy AJ, Gibson-Corley KN, Cox JE, Burgess SC, Taylor EB Mol Metab 2017 Nov 6 11 1468-1479 Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis. Morris EM, McCoin CS, Allen JA, Gastecki ML, Koch LG, Britton SL, Fletcher JA, Fu X, Ding WX, Burgess SC, Rector RS, Thyfault JP J. Physiol. (Lond.) 2017 May Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity. Kucejova B, Duarte J, Satapati S, Fu X, Ilkayeva O, Newgard CB, Brugarolas J, Burgess SC Cell Rep 2016 Jun Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC J. Clin. Invest. 2015 Dec 125 12 4447-4462 Results 1-10 of 96 1 2 3 4 5 Next Last Honors & Awards Daryl K. Granner Lectureship (2016) Robert A. Welch Foundation Research Grant Award (2013) ADA Basic Science Award (2009) American Diabetes Junior Faculty Award (2005)
