Education

Undergraduate
Washington State University (1983), Chemistry
Graduate School
Uni of Wisconsin-Madison (1990), Chemistry

Research Interest

  • Molecular mechanisms of neurotransmitter release, as studied by x-ray crystallography.
  • Structure and function of lipoproteins from the bacterium T. pallidum, the causative agent of syphilis.
  • Structure and mechanism of enzymes and metalloenzymes.
  • Structure of proteins involved in cell signaling and division.

Publications

Featured Publications LegendFeatured Publications

Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT).
Brautigam CA, Deka RK, Schuck P, Tomchick DR, Norgard MV J. Mol. Biol. 2012 Jun 420 1-2 70-86
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting.
Kim S, Sun H, Tomchick DR, Yu H, Luo X Proc. Natl. Acad. Sci. U.S.A. 2012 Apr 109 17 6549-54
Structural, bioinformatic, and in vivo analyses of two Treponema pallidum lipoproteins reveal a unique TRAP transporter.
Deka RK, Brautigam CA, Goldberg M, Schuck P, Tomchick DR, Norgard MV J. Mol. Biol. 2012 Mar 416 5 678-96
Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing.
Matos MF, Xu Y, Dulubova I, Otwinowski Z, Richardson JM, Tomchick DR, Rizo J, Ho A Proc. Natl. Acad. Sci. U.S.A. 2012 Mar 109 10 3802-7
Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5).
Thompson JW, Salahudeen AA, Chollangi S, Ruiz JC, Brautigam CA, Makris TM, Lipscomb JD, Tomchick DR, Bruick RK J. Biol. Chem. 2012 Mar 287 10 7357-65
The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors.
Li W, Ma C, Guan R, Xu Y, Tomchick DR, Rizo J Structure 2011 Oct 19 10 1443-55
A single active-site mutation of P450BM-3 dramatically enhances substrate binding and rate of product formation.
Haines DC, Hegde A, Chen B, Zhao W, Bondlela M, Humphreys JM, Mullin DA, Tomchick DR, Machius M, Peterson JA Biochemistry 2011 Oct 50 39 8333-41
Mechanism of actin filament nucleation by the bacterial effector VopL.
Yu B, Cheng HC, Brautigam CA, Tomchick DR, Rosen MK Nat. Struct. Mol. Biol. 2011 Sep 18 9
The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.
Selyunin AS, Sutton SE, Weigele BA, Reddick LE, Orchard RC, Bresson SM, Tomchick DR, Alto NM Nature 2011 Jan 469 7328 107-11
Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
Deng X, Lee J, Michael AJ, Tomchick DR, Goldsmith EJ, Phillips MA J. Biol. Chem. 2010 Aug 285 33 25708-19

Honors & Awards

  • American Heart Association Postdoctoral Fellowship
    (1991-1993)
  • National Merit Scholar
    Washington State University (1979-1983)

Professional Associations/Affiliations

  • American Society for Microbiology (2003-2018)
  • American Association for the Advancement of Science (1989-2018)
  • American Chemical Society (1986-2018)
  • American Crystallographic Association (1986-2018)