Education

Undergraduate
Washington State University (1983), Chemistry
Graduate School
Uni of Wisconsin-Madison (1990), Chemistry

Research Interest

  • Molecular mechanisms of neurotransmitter release, as studied by x-ray crystallography.
  • Structure and function of lipoproteins from the bacterium T. pallidum, the causative agent of syphilis.
  • Structure and mechanism of enzymes and metalloenzymes.
  • Structure of proteins involved in cell signaling and division.

Publications

Featured Publications LegendFeatured Publications

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Volkov OA, Kinch L, Ariagno C, Deng X, Zhong S, Grishin N, Tomchick DR, Chen Z, Phillips MA Elife 2016 Dec 5
Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy.
Kikuchi S, Borek DM, Otwinowski Z, Tomchick DR, Yu H Proc. Natl. Acad. Sci. U.S.A. 2016 Oct
A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria.
Phillips MA, White KL, Kokkonda S, Deng X, White J, El Mazouni F, Marsh KC, Tomchick DR, Manjalanagara K, Rudra KR, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Shackleford DM, Chiu FC, Campbell M, Jimenez Diaz MB, Ferrer-Bazaga S, Angulo-Barturen I, Martínez-Martínez MS, Lafuente-Monasterio MJ, Kaminsky W, Silue K, Zeeman AM, Kocken C, Leroy D, Blasco B, Rossignol E, Rueckle T, Matthews D, Burrows JN, Waterson D, Palmer MJ, Rathod PK, Charman SA ACS Infect Dis 2016 Sep
Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidines targeting Plasmodium falciparum dihydroorotate dehydrogenase display potent and selective antimalarial activity.
Kokkonda S, Deng X, White KL, Coterón JM, Marco M, de Las Heras L, White J, El Mazouni F, Tomchick DR, Manjalanagara K, Rudra KR, Chen G, Morizzi J, Ryan E, Kaminsky W, Leroy D, Martínez-Martínez MS, Jimenez Diaz MB, Bazaga SF, Angulo-Barturen I, Waterson D, Burrows JN, Matthews D, Charman SA, Phillips MA, Rathod PK J. Med. Chem. 2016 Apr
Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.
Dodd DW, Tomchick DR, Corey DR, Gagnon KT Biochemistry 2016 Feb
Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm.
Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV Microbiologyopen 2015 Dec
Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution.
Brewer KD, Bacaj T, Cavalli A, Camilloni C, Swarbrick JD, Liu J, Zhou A, Zhou P, Barlow N, Xu J, Seven AB, Prinslow EA, Voleti R, Häussinger D, Bonvin AM, Tomchick DR, Vendruscolo M, Graham B, Südhof TC, Rizo J Nat. Struct. Mol. Biol. 2015 Jun
Coiled-coil Coactivators Play a Structural Role Mediating Interactions in Hypoxia Inducible Factor Heterodimerization.
Guo Y, Scheuermann TH, Partch CL, Tomchick DR, Gardner KH J. Biol. Chem. 2015 Jan
Evidence for Posttranslational Protein Flavinylation in the Syphilis Spirochete Treponema pallidum: Structural and Biochemical Insights from the Catalytic Core of a Periplasmic Flavin-Trafficking Protein.
Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV MBio 2015 6 3 e00519-15
Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation.
Rivera-Cancel G, Ko WH, Tomchick DR, Correa F, Gardner KH Proc. Natl. Acad. Sci. U.S.A. 2014 Dec 111 50 17839-44

Honors & Awards

  • American Heart Association Postdoctoral Fellowship
    (1991-1993)
  • National Merit Scholar
    Washington State University (1979-1983)

Professional Associations/Affiliations

  • American Society for Microbiology (2003-2018)
  • American Association for the Advancement of Science (1989-2018)
  • American Chemical Society (1986-2018)
  • American Crystallographic Association (1986-2018)