Washington State University (1983), Chemistry
Graduate School
Uni of Wisconsin-Madison (1990), Chemistry

Research Interest

  • Molecular mechanisms of neurotransmitter release, as studied by x-ray crystallography.
  • Structure and function of lipoproteins from the bacterium T. pallidum, the causative agent of syphilis.
  • Structure and mechanism of enzymes and metalloenzymes.
  • Structure of proteins involved in cell signaling and division.


Featured Publications LegendFeatured Publications

Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
Zhou T, Kurnasov O, Tomchick DR, Binns DD, Grishin NV, Marquez VE, Osterman AL, Zhang H J. Biol. Chem. 2002 Apr 277 15 13148-54
Three-dimensional structure of the complexin/SNARE complex.
Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J Neuron 2002 Jan 33 3 397-409
Pivotal role of water in the mechanism of P450BM-3.
Haines DC, Tomchick DR, Machius M, Peterson JA Biochemistry 2001 Nov 40 45 13456-65
Structure of rat BCKD kinase: nucleotide-induced domain communication in a mitochondrial protein kinase.
Machius M, Chuang JL, Wynn RM, Tomchick DR, Chuang DT Proc. Natl. Acad. Sci. U.S.A. 2001 Sep 98 20 11218-23
Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Tomchick DR, Phan P, Cymborowski M, Minor W, Holman TR Biochemistry 2001 Jun 40 25 7509-17
Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase.
Tomchick DR, Turner RJ, Switzer RL, Smith JL Structure 1998 Mar 6 3 337-50
Mechanism of the synergistic end-product regulation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase by nucleotides.
Chen S, Tomchick DR, Wolle D, Hu P, Smith JL, Switzer RL, Zalkin H Biochemistry 1997 Sep 36 35 10718-26
Structure and function of the glutamine phosphoribosylpyrophosphate amidotransferase glutamine site and communication with the phosphoribosylpyrophosphate site.
Kim JH, Krahn JM, Tomchick DR, Smith JL, Zalkin H J. Biol. Chem. 1996 Jun 271 26 15549-57
A protein catalytic framework with an N-terminal nucleophile is capable of self-activation.
Brannigan JA, Dodson G, Duggleby HJ, Moody PC, Smith JL, Tomchick DR, Murzin AG Nature 1995 Nov 378 6555 416-9
Three-dimensional structure of myosin subfragment-1: a molecular motor.
Rayment I, Rypniewski WR, Schmidt-Bäse K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM Science 1993 Jul 261 5117 50-8

Honors & Awards

  • American Heart Association Postdoctoral Fellowship
  • National Merit Scholar
    Washington State University (1979-1983)

Professional Associations/Affiliations

  • American Society for Microbiology (2003-2018)
  • American Association for the Advancement of Science (1989-2018)
  • American Chemical Society (1986-2018)
  • American Crystallographic Association (1986-2018)