Washington State University (1983), Chemistry
Graduate School
Uni of Wisconsin-Madison (1990), Chemistry

Research Interest

  • Molecular mechanisms of neurotransmitter release, as studied by x-ray crystallography.
  • Structure and function of lipoproteins from the bacterium T. pallidum, the causative agent of syphilis.
  • Structure and mechanism of enzymes and metalloenzymes.
  • Structure of proteins involved in cell signaling and division.


Featured Publications LegendFeatured Publications

Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain.
Luong P, Kinch LN, Brautigam CA, Grishin NV, Tomchick DR, Orth K J. Biol. Chem. 2010 Jun 285 26 20155-63
Structural and functional analysis of the YAP-binding domain of human TEAD2.
Tian W, Yu J, Tomchick DR, Pan D, Luo X Proc. Natl. Acad. Sci. U.S.A. 2010 Apr 107 16 7293-8
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Shin OH, Lu J, Rhee JS, Tomchick DR, Pang ZP, Wojcik SM, Camacho-Perez M, Brose N, Machius M, Rizo J, Rosenmund C, Südhof TC Nat. Struct. Mol. Biol. 2010 Mar 17 3 280-8
Crystal structure of the Formin mDia1 in autoinhibited conformation.
Otomo T, Tomchick DR, Otomo C, Machius M, Rosen MK PLoS ONE 2010 5 9
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J PLoS ONE 2010 5 9
Localization and structure of the ankyrin-binding site on beta2-spectrin.
Davis L, Abdi K, Machius M, Brautigam C, Tomchick DR, Bennett V, Michaely P J. Biol. Chem. 2009 Mar 284 11 6982-7
Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Scheuermann TH, Tomchick DR, Machius M, Guo Y, Bruick RK, Gardner KH Proc. Natl. Acad. Sci. U.S.A. 2009 Jan 106 2 450-5
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.
Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H Mol. Cell 2008 Nov 32 3 394-405
Changes at the KinA PAS-A dimerization interface influence histidine kinase function.
Lee J, Tomchick DR, Brautigam CA, Machius M, Kort R, Hellingwerf KJ, Gardner KH Biochemistry 2008 Apr 47 13 4051-64
Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel.
Haines DC, Chen B, Tomchick DR, Bondlela M, Hegde A, Machius M, Peterson JA Biochemistry 2008 Mar 47 12 3662-70

Honors & Awards

  • American Heart Association Postdoctoral Fellowship
  • National Merit Scholar
    Washington State University (1979-1983)

Professional Associations/Affiliations

  • American Society for Microbiology (2003-2018)
  • American Association for the Advancement of Science (1989-2018)
  • American Chemical Society (1986-2018)
  • American Crystallographic Association (1986-2018)