Washington State University (1983), Chemistry
Graduate School
Uni of Wisconsin-Madison (1990), Chemistry

Research Interest

  • Molecular mechanisms of neurotransmitter release, as studied by x-ray crystallography.
  • Structure and function of lipoproteins from the bacterium T. pallidum, the causative agent of syphilis.
  • Structure and mechanism of enzymes and metalloenzymes.
  • Structure of proteins involved in cell signaling and division.


Featured Publications LegendFeatured Publications

Substrate-Specific Activation of the Mitotic Kinase Bub1 through Intramolecular Autophosphorylation and Kinetochore Targeting.
Lin Z, Jia L, Tomchick DR, Luo X, Yu H Structure 2014 Oct
Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.
Hara K, Zheng G, Qu Q, Liu H, Ouyang Z, Chen Z, Tomchick DR, Yu H Nat. Struct. Mol. Biol. 2014 Aug
Identification of Lysine Residues in the Borrelia burgdorferi DbpA Adhesin Required for Murine Infection.
Fortune DE, Lin YP, Deka RK, Groshong AM, Moore BP, Hagman KE, Leong JM, Tomchick DR, Blevins JS Infect. Immun. 2014 May
Re-examining how complexin inhibits neurotransmitter release: SNARE complex insertion or electrostatic hindrance?
Trimbuch T, Xu J, Flaherty D, Tomchick DR, Rizo J, Rosenmund C Elife 2014 May e02391
Structure and ca(2+)-binding properties of the tandem c2 domains of e-syt2.
Xu J, Bacaj T, Zhou A, Tomchick DR, S├╝dhof TC, Rizo J Structure 2014 Feb 22 2 269-80
The Bacterial Effector VopL Organizes Actin into Filament-like Structures.
Zahm JA, Padrick SB, Chen Z, Pak CW, Yunus AA, Henry L, Tomchick DR, Chen Z, Rosen MK Cell 2013 Oct 155 2 423-34
Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5.
Ni L, Li S, Yu J, Min J, Brautigam CA, Tomchick DR, Pan D, Luo X Structure 2013 Aug
Structure of the human cohesin inhibitor Wapl.
Ouyang Z, Zheng G, Song J, Borek DM, Otwinowski Z, Brautigam CA, Tomchick DR, Rankin S, Yu H Proc. Natl. Acad. Sci. U.S.A. 2013 Jun
Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis.
Brautigam CA, Deka RK, Ouyang Z, Machius M, Knutsen G, Tomchick DR, Norgard MV J. Bacteriol. 2012 Dec 194 24 6771-81
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Tian W, Li B, Warrington R, Tomchick DR, Yu H, Luo X Proc. Natl. Acad. Sci. U.S.A. 2012 Nov 109 45 18419-24

Honors & Awards

  • American Heart Association Postdoctoral Fellowship
  • National Merit Scholar
    Washington State University (1979-1983)

Professional Associations/Affiliations

  • American Society for Microbiology (2003-2018)
  • American Association for the Advancement of Science (1989-2018)
  • American Chemical Society (1986-2018)
  • American Crystallographic Association (1986-2018)