Diana Tomchick, Ph.D.

• Molecular mechanisms of neurotransmitter release, as studied by x-ray crystallography.
• Structure and function of lipoproteins from the bacterium T. pallidum, the causative agent of syphilis.
• Structure and mechanism of enzymes and metalloenzymes.
• Structure of proteins involved in cell signaling and division.

 Featured Publications

Mechanistic Insights into Neurotransmitter Release and Presynaptic Plasticity from the Crystal Structure of Munc13-1 C1C2BMUN.

Xu J, Camacho M, Xu Y, Esser V, Liu X, Trimbuch T, Pan YZ, Ma C, Tomchick DR, Rosenmund C, Rizo J Elife 2017 Feb 6

Phosphorylation of spore coat proteins by a family of atypical protein kinases.

Nguyen KB, Sreelatha A, Durrant ES, Lopez-Garrido J, Muszewska A, Dudkiewicz M, Grynberg M, Yee S, Pogliano K, Tomchick DR, Pawlowski K, Dixon JE, Tagliabracci VS Proc. Natl. Acad. Sci. U.S.A. 2016 May

Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics.

Ouyang Z, Zheng G, Tomchick DR, Luo X, Yu H Mol. Cell 2016 Mar

Bile salt receptor complex activates a pathogenic type III secretion system.

Li P, Rivera-Cancel G, Kinch LN, Salomon D, Tomchick DR, Grishin NV, Orth K Elife 2016 5

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA Sci Transl Med 2015 Jul 7 296 296ra111

The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis.

Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV J. Biol. Chem. 2013 Feb

Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1.

Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK Cell 2010 Jan 140 2 246-56

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.

Bae SJ, Ni L, Osinski A, Tomchick DR, Brautigam CA, Luo X Elife 2017 Oct 6

Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.

Voleti R, Tomchick DR, Südhof TC, Rizo J Proc. Natl. Acad. Sci. U.S.A. 2017 Sep

Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.

Brautigam CA, Deka RK, Liu WZ, Tomchick DR, Norgard MV Protein Sci. 2017 Feb

• American Heart Association Postdoctoral Fellowship
  (1991-1993)
• National Merit Scholar
  Washington State University (1979-1983)

• American Association for the Advancement of Science (1989-2018)
• American Chemical Society (1986-2018)
• American Crystallographic Association (1986-2018)
• American Society for Microbiology (2003-2018)