Download Curriculum Vitae

Prashant Mishra received his undergraduate degree in biochemical sciences from Harvard University. He received his M.D. and Ph.D. degrees from the University of Texas Southwestern Medical Center, where he studied the role of scaffolding in signaling pathways with Dr. Rama Ranganathan. As a fellow of the Jane Coffin Childs Memorial Fund, he conducted postdoctoral work on regulation of mitochondrial behavior in the laboratory of Dr. David Chan at the California Institute of Technology.

In 2015, he joined the faculty of Children's Medical Center Research Institute at UT Southwestern

Research in the Mishra lab is focused on mapping how the mitochondria are embedded into normal cellular function. This research will help identify new insights into mitochondrial diseases and allow the Mishra lab to develop clinical tools and therapeutic options.

Mishra Laboratory


Harvard University (1999), Biochemistry
Graduate School
Univ of Tx Southwestern Med Ct (2007), Biophysics
Medical School
Univ of Tx Southwestern Med Ct (2009), Medicine

Research Interest

  • Metabolism
  • Mitochondrial diseases
  • Organelle behavior and function


Featured Publications LegendFeatured Publications

a-ketobutyrate links alterations in cystine metabolism to glucose oxidation in mtDNA mutant cells.
Lesner NP, Gokhale A, Kota K, DeBerardinis RJ, Mishra P, Metab. Eng. 2020 Apr
Mitochondrial dynamics and inheritance during cell division, development and disease.
Mishra P, Chan DC Nat. Rev. Mol. Cell Biol. 2014 Oct 15 10 634-46
Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.
Sapir A, Tsur A, Koorman T, Ching K, Mishra P, Bardenheier A, Podolsky L, Bening-Abu-Shach U, Boxem M, Chou TF, Broday L, Sternberg PW Proc. Natl. Acad. Sci. U.S.A. 2014 Sep 111 37 E3880-9
Dynamic scaffolding in a G protein-coupled signaling system.
Mishra P, Socolich M, Wall MA, Graves J, Wang Z, Ranganathan R Cell 2007 Oct 131 1 80-92
Natural-like function in artificial WW domains.
Russ WP, Lowery DM, Mishra P, Yaffe MB, Ranganathan R Nature 2005 Sep 437 7058 579-83