Paul E. Pepe, M.D., M.P.H., a Professor with Tenure in Internal Medicine, Surgery, Pediatrics, Public Health & Emergency Medicine (EM) at UT Southwestern, is also the EMS/Public Safety Medical Director for Dallas County and Global Coordinator for the Metropolitan EMS Medical Directors ("Eagles") Alliance.
An extremely distinguished academician, he headed the clinical, administrative, academic and research programs in EM at UT Southwestern between 2000 and 2014 and was EM Chair at the Medical College of Pennsylvania Pittsburgh campus in the 1990s.
With over 400 full-length published scientific papers, including many landmark publications, Dr. Pepe has served simultaneously as a high-level municipal or state employee for nearly four decades. Renown for a grass-roots, street-wise style in planning, implementing and overseeing a systems approach to saving lives, both operationally and through clinical trials, his programs have resulted in some of the highest cardiac arrest and trauma survival rates worldwide. In addition to the Chain of Survival publication, he is known for his original measurements of physiological mechanisms (eg, Auto-PEEP), intrepid clinical concepts (eg, deferred rescue breaths in CPR), and ground-breaking clinical trials (eg, deferred IV fluids for trauma). Published years ago by Dr. Pepe & colleagues, these studies are now part of mainstream medical practice and research efforts. Current advances include life-saving projects such as the first clinical use of head-up/torso-up CPR and techniques to effect improved survival chances for pediatric cardiac arrest.
Many of his numerous studies, injury prevention programs and media interactions have consistently affected public policy and legislation. Helping to set national priorities for cardiac and trauma resuscitation research, the NIH formally designated his EM program at UT as a federally-funded resuscitation research center in 2004, a very successful program that continued throughout his entire tenure as the division chair of Emergency Medicine.
Over his career, he served as an assistant to the medical directors of the Seattle Fire Department EMS (1977-82), as Director for the City of Houston EMS System (1982-96) and as Commonwealth Emergency Medical Director for Pennsylvania under Governor Tom Ridge in the late 1990s. In addition, Dr. Pepe has served for years as emergency medicine-trauma consultant to various entities such as the White House Medical Unit, U.S. Secret Service (USSS), FBI, NIH, FDA, network news organizations, and even the National Basketball Association Trainers. He coordinates the so-called Eagles consortium, a cohesive and highly-influential de facto coalition of the jurisdictional 9-1-1 (EMS) system medical directors for the nation’s 40-50 largest cities and counterparts in Europe and elsewhere as well as pivotal federal agencies (eg, FBI, USSS, ATF, HHS, White House Medical Unit).
An omnipresent global lecturer, he has won numerous health policy, community service, scientific, educational and professional society awards, here and abroad, including distinguished alumnus awards and a formal citation for courage and life-time public service in the U.S. Congressional Record. He was elected to Mastership in the American College of Physicians (MACP) for numerous lifetime achievements in Internal Medicine and received similar recognition in 2014 from the Society for Academic Emergency Medicine for lifetime achievements and excellence in research . In 2016, he was designated as a Master of Critical Care Medicine (MCCM) by the Society for Critical Care Medicine.
Often featured on network news and prime-time broadcasts (e.g., Rescue 9-1-1 pilot, ABC News Nightline special, ’In the ER’, TLC’s award-winning, ’The Strongest Link’, and Larry King Live), he has been called a ’Mentor to Millions’ and an ’Advocate for the Injured’. When receiving a major national award a decade ago in Washington, DC for lifetime professional achievements (presented by then U.S. Surgeon General, Richard Carmona, on behalf of the American College of Emergency Physicians), Dr. Pepe was cited as the most accomplished emergency medical services physician of our generation.
- Medical School
- University of California at San Francisco (1976)
- University of Washington School of Medicine (1979), Internal Medicine
- University of Washington Medical Center (1982), Pulmonary Diseases & Critical Care Medicine
- Graduate School
- University of Texas School of Public Health (1995)
- Clinical Trials of Interventions for Cardiac Arrest Resuscitation
- Clinical Trials of Interventions for Trauma Resuscitation
- EMS System Organization
- Event Medicine and Mass Gathering Medicine
- Interventions for Coronary Artery Syndromes
- Optimization of Ventilatory Techniques in Severe Hemorrhage and Cardiac Arrest
- Use of Hormones in Resuscitation
- Confirming the Clinical Safety and Feasibility of a Bundled Methodology to Improve Cardiopulmonary Resuscitation Involving a Head-Up/Torso-Up Chest Compression Technique.
- Pepe PE, Scheppke KA, Antevy PM, Crowe RP, Millstone D, Coyle C, Prusansky C, Garay S, Ellis R, Fowler RL, Moore JC Crit. Care Med. 2019 Mar 47 3 449-455
- Consistent Head Up Cardiopulmonary Resuscitation Haemodynamics Are Observed Across Porcine and Human Cadaver Translational Models.
- Moore J, Holley J, Segal N, Lick M, Labarère J, Frascone RJ, Dodd K, Robinson A, Lick C, Klein L, Ashton A, McArthur A, Tsangaris A, Makaretz A, Makaretz M, Debaty G, Pepe PE, Lurie K Resuscitation 2018 Apr
- Quality of CPR: An important effect modifier in cardiac arrest clinical outcomes and intervention effectiveness trials.
- Yannopoulos D, Aufderheide TP, Abella BS, Duval S, Frascone RJ, Goodloe JM, Mahoney BD, Nadkarni VM, Halperin HR, O'Connor R, Idris AH, Becker LB, Pepe PE Resuscitation 2015 Jun
- Partnering medicine and public service.
- Pepe PE ICU Management 2015 84-86.
- Neuroprotection in the Acutely Ill:
- Stocchetti N (Co-Chair), Taccone FS, Citerio G, Pepe PE (Co-Chair) and others on behalf of the International Round Table on Neuroprotection in the Acutely Ill: Crit Care 2014 19
- The Resuscitation Outcomes Consortium (ROC) PRIMED impedance threshold device (ITD) cardiac arrest trial: A prospective, multi-center, randomized, double-blind, controlled, clinical investigation.
- Aufderheide TP, Nichol G, Rea TD, Everson-Stewart S, Leroux BG, Pepe PE, others for the National Institutes of Health Resuscitation Outcomes Consortium N Engl J Med 2011 365 9 798-80.
- Rationale for routine and immediate administration of intravenous estrogen for all critically ill and injured patients.
- Wigginton JG, Pepe PE, Idris AH Crit. Care Med. 2010 Oct 38 10 Suppl S620-9
- Clinical trials in the out-of-hospital setting: rationale and strategies for successful implementation.
- Pepe PE, Copass MK, Sopko G Crit. Care Med. 2009 Jan 37 1 Suppl S91-101
- Acutely decompensated heart failure in a county emergency department: a double-blind, randomized, controlled comparison of nesiritide vs. placebo treatment.
- Miller AH, Nazeer S, Pepe PE, Estes B, Gorman A, Yancy C. Ann Emeg Med May 2008 51 580-582
- Prospective, randomized trial of the effectiveness and retention of 30-minute layperson training for cardiopulmonary resuscitation and automated external defibrillators
- Roppolo LP, Pepe PE, Campbell L, et al Resuscitation August 2007 67 276-285
Avoiding Common Prehospital Errors
Lawner BJ, Slovis CM, Fowler R, Pepe P, Mattu A (Editors). (Ed.) (2013). Philadephia, Wolters and Kluwer Health, Lippincott Williams and Williams,
Medical direction of emergency medical services systems.. In Clinical Practice and Systems Oversight, Cone DC, Fowler R, O? Connor RE (eds). Textbook of the National Association of EMS Physicians
Pepe PE, Copass MK, Fowler RL, Racht EM (2009). Dubuque, IA, Kendall Hunt Publications,.
EMS physicians as public spokespersons: ten golden rules for public speaking.. In Emergency Medical Services: Clinical Practice and Systems Oversight, Brice J, Cone DC, Delbridge T, Myers JB (eds). Textbook of the National Association of EMS Physicians, 2nd Edition
Pepe PE, Pepe LL, Davis R, Mann P, Whitmeyer R (2015). Oxford, UK, Wiley-Blackwell Publications
Event medicine: an evolving sub-specialty of emergency medicine... In 2013 Yearbook of Intensive Care and Emergency Medicine. Vincent JL (ed)
Pepe PE and Nichols S (2013). Berlin Heidelberg, Germany, Springer-Verlag
Prehospital endotracheal intubation: elemental or detriemntal ?. In 2015 Yearbook of Intensive Care and Emergency Medicine. Vincent JL (ed)
Pepe PE, Roppolo LP, Fowler RL. (2015). Berlin Heidelberg, Germany., Springer-Verlag
Foreword. In Law Enforcement Responder: Principles of Emergency Medicine, Rescue and Force Protection
Pepe PE (2012). Burlington MA,, Jones and Bartlett Learning
Transportation Medicine. In The Oxford Textbook of Critical Care, 2nd edition; Webb A, Angus D, Finfer S, Gattinoni L: Singer M (eds)
Klein KR, Pepe PE (2015). Oxford, UK, Oxford University Press
4. Pepe PE. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries.. In 50 Landmark Papers Every Trauma Surgeon Should Know.
Pepe PE (2019). Boca Raton, Florida, CRC Press
Honors & Awards
- Selected to be a Plenary Speaker for the 2019 Annual Meeting of the Society for Critical Care Medicine
Featured Speaker for annual meeting of the main society for critical care specialists (2019)
- Designated as a Master of Critical Care Medicine (MCCM) by the Society for Critical Care Medicine
Selected for achievements as a prominent and distinguished leader of international stature,personal character, eminence in clinical practice, and outstanding contributions to research and education in the field of critical care (2016)
- Named Science Officer for the Canadian Institutes of Health Research (CIHR)
Lead member of CIHR study sections that evaluate the quality and priority scoring of scientific grant applications and write the executive summary on behalf of the CIHR (2015)
- Excellence in Research Award from the Society for Academic Emergency Medicine
Awarded for lifetime achievements in research and advancing the mission of the specialty of Emergency Medicine (2014)
- National Finalist, Emergency Medicine Foundation Emergency Department Director of the Year Award
Recognized for dramatic improvements in both emergency department throughput and patient satisfaction as well as cost-sparing, life-sparing initiatives in the prehospital setting (2010)
- Elected to Mastership (MACP) by the American College of Physicians (ACP)
Honored for life-time achievements and scientific and professional contributions in the field of Internal Medicine (2008)
- Received the National Emergency Medical Services Award from the American College of Emergency Physicians (ACEP)
Honored for life-time achievements and cited as the most accomplished Emergency Medical Services physicians of our generation (2005)
- Recognized in the U.S. Congressional Record
Honored for heroism and life-time achievements in 9-1-1 emergency services, trauma care and disaster management (2005)
- Received Millenium-2000 Award from the Australian and New Zealand Intensive Care Society (ANZICS)
Awarded for life-time achievement and scientific contributions to the field of Critical Care Medicine worldwide (2000)
- Appointed Emergency Medicine and Trauma Consultant to the White House Medical Unit (WHMU)
Since 1994, assigned to train and advise the White House physicians, nurses, physician assistants and other medical personnel, including the Physician to the President, in the latest EM and Trauma care advances and resuscitation techniques (1994)
- American Association for the Surgery of Trauma (AAST), Consulting Scientist (2001)
- Metropolitan EMS Medical Directors Alliance, Global Coordinator (1998)
- American College of Critical Care Medicine,.Master (MCCM) (1990)
- Society for Academic Emergency Medicine (winner of Silver Anniversary Excellence in Research Award) (1989)
- American College of Emergency Physicians, Fellow (FACEP, winner of National Emergency Medical Services Award) (1986)
- American College of Physicians, Master (MACP) (1984)
- National Association of EMS Physicians (Co-Founder, first President-Elect and inaugural FAEMS recipient) (1984)