Anne Satterthwaite, Ph.D.

Anne Satterthwaite, Ph.D., is an Associate Professor in the Departments of Internal Medicine and Immunology at UT Southwestern Medical Center and a member of the Division of Rheumatic Diseases.

Originally from Long Beach, California, Dr. Satterthwaite holds a bachelor's degree in life sciences from the Massachusetts Institute of Technology. She earned her doctorate at Harvard University in Cambridge, Massachusetts. She completed a postdoctoral fellowship at the University of California Los Angeles.

Dr. Satterthwaite joined the UT Southwestern faculty in 2000 as an Assistant Professor. She was promoted to Associate Professor in 2008.

At UT Southwestern, Dr. Satterthwaite is Chair of the Immunology Graduate Program and Course Director of Frontiers in Medicine: Autoimmunity. She is also a member of the Women in Science and Medicine Advisory Committee.

Dr. Satterthwaite is a member of the American Association of Immunologists and the American College of Rheumatology.

Undergraduate

Massachusetts Inst of Technol (1987), Life Sciences

Graduate School

Harvard University (1993), Cell Biology

• Autoimmunity
• B cell development
• Immunodeficiency
• Signal transduction

Featured Publications

Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels.

Mayeux J, Skaug B, Luo W, Russell LM, John S, Saelee P, Abbasi H, Li QZ, Garrett-Sinha LA, Satterthwaite AB J. Immunol. 2015 Jul

A Balance between B Cell Receptor and Inhibitory Receptor Signaling Controls Plasma Cell Differentiation by Maintaining Optimal Ets1 Levels.

Luo W, Mayeux J, Gutierrez T, Russell L, Getahun A, Müller J, Tedder T, Parnes J, Rickert R, Nitschke L, Cambier J, Satterthwaite AB, Garrett-Sinha LA J. Immunol. 2014 Jun

IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn(-/-) mice.

Gutierrez T, Mayeux JM, Ortega SB, Karandikar NJ, Li QZ, Rakheja D, Zhou XJ, Satterthwaite AB Eur. J. Immunol. 2013 Feb 43 2 382-93

Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.

Hutcheson J, Vanarsa K, Bashmakov A, Grewal S, Sajitharan D, Chang BY, Buggy JJ, Zhou XJ, Du Y, Satterthwaite AB, Mohan C Arthritis Res. Ther. 2012 Nov 14 6 R243

Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient mice.

Gutierrez T, Halcomb KE, Coughran AJ, Li QZ, Satterthwaite AB Eur. J. Immunol. 2010 Jul 40 7 1897-905

Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.

Halcomb KE, Musuka S, Gutierrez T, Wright HL, Satterthwaite AB Mol. Immunol. 2008 Dec 46 2 233-41

Btk and phospholipase C gamma 2 can function independently during B cell development.

Halcomb KE, Contreras CM, Hinman RM, Coursey TG, Wright HL, Satterthwaite AB Eur. J. Immunol. 2007 Apr 37 4 1033-42

Btk regulates multiple stages in the development and survival of B-1 cells.

Contreras CM, Halcomb KE, Randle L, Hinman RM, Gutierrez T, Clarke SH, Satterthwaite AB Mol. Immunol. 2007 Apr 44 10 2719-28

B cell receptor signaling down-regulates forkhead box transcription factor class O 1 mRNA expression via phosphatidylinositol 3-kinase and Bruton's tyrosine kinase.

Hinman RM, Bushanam JN, Nichols WA, Satterthwaite AB J. Immunol. 2007 Jan 178 2 740-7

Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication.

Pisitkun P, Deane JA, Difilippantonio MJ, Tarasenko T, Satterthwaite AB, Bolland S Science 2006 Jun 312 5780 1669-72

 Featured Books

X-linked Agammaglobulinemia: A Disease of Btk tyrosine kinase.. In Primary Immunodeficiency Diseases: A Molecular and Genetic Approach, 2nd ed.

Smith CIE, Satterthwaite AB, and Witte ON (). New York, NY, Oxford University Press

• Preclinical Teaching Award MS1, Immunology
  UT Southwestern (2013)
• Peggy Chavellier Professorship in Arthritis Care and Research
  UT Southwestern Medical Foundation (2012)
• Southwestern Medical Foundation Scholar in Biomedical Research
  UT Southwestern (2000)
• Leukemia and Lymphoma Society Special Fellowship
  (1998)
• Irvington Institute for Immunological Research Postdoctoral Fellowship
  (1994)

• American Association of Immunologists (2004)