Dinesh Rakheja, M.D. - Faculty Profile

Biography

Dr. Rakheja did his medical schooling at All India Institute of Medical Sciences in New Delhi. He completed pathology residencies at Maulana Azad Medical College (Delhi University) and UT Southwestern Medical Center. He trained in gastrointestinal pathology and neuropathology as a senior resident (fellow equivalent) at GB Pant Hospital (Delhi University) and completed a pediatric pathology fellowship at UT Southwestern/Children’s Medical Center.

Dr. Rakheja studies the genetics and metabolism of childhood cancer. He has specific interests in tumor tissue banking, establishing primary pediatric cancer cell lines, and developing laboratory assays for diagnostic, prognostic, and therapeutic targets in pediatric cancers.

Education

Medical School: All India Institute of Medical Sciences, India (1993)
Residency: Maulana Azad Hospitals (1997), Pathology
Residency: G. B. Pant Hospital (1999), Pathology
Residency: UT Southwestern Medical Center (2003), Pathology
Fellowship: UT Southwestern/Children's Medical Center (2006), Pediatric Pathology

Research Interest

Publications

Featured Publications

Oncometabolites: A New Paradigm for Oncology, Metabolism, and the Clinical Laboratory.: Collins RRJ, Patel K, Putnam WC, Kapur P, Rakheja D Clin. Chem. 2017 Oct
EGFR Exon 20 Insertion/Duplication Mutations Characterize Fibrous Hamartoma of Infancy.: Park JY, Cohen C, Lopez D, Ramos E, Wagenfuehr J, Rakheja D Am. J. Surg. Pathol. 2016 Sep
Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.: Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF Nat Commun 2014 2 4802
CLN3P, the Batten's disease protein, is a novel palmitoyl-protein Delta-9 desaturase.: Narayan SB, Rakheja D, Tan L, Pastor JV, Bennett MJ Ann. Neurol. 2006 Nov 60 5 570-7
Evidence for fatty acid oxidation in human placenta, and the relationship of fatty acid oxidation enzyme activities with gestational age.: Rakheja D, Bennett MJ, Foster BM, Domiati-Saad R, Rogers BB Placenta 2002 May 23 5 447-50
KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes.: Wang A, Fairhurst AM, Liu K, Wakeland B, Barnes S, Malladi VS, Viswanathan K, Arana C, Dozmorov I, Singhar A, Du Y, Imam M, Moses A, Chen C, Sunkavalli A, Casco J, Rakheja D, Li QZ, Mohan C, Clayberger C, Wakeland EK, Khan S, Commun Biol 2024 Nov 7 1 1446
Histopathology Based AI Model Predicts Anti-Angiogenic Therapy Response in Renal Cancer Clinical Trial.: Jasti J, Zhong H, Panwar V, Jarmale V, Miyata J, Carrillo D, Christie A, Rakheja D, Modrusan Z, Kadel EE, Beig N, Huseni M, Brugarolas J, Kapur P, Rajaram S, ArXiv 2024 May
Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors.: Collins RRJ, Gee RRF, Sanchez MCH, Tozandehjani S, Bayat T, Breznik B, Lee AK, Peters ST, Connelly JP, Pruett-Miller SM, Roussel MF, Rakheja D, Tillman HS, Potts PR, Fon Tacer K, bioRxiv 2024 May
L-2-hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.: Kundu A, Brinkley GJ, Nam H, Karki S, Kirkman R, Pandit M, Shim E, Widden H, Liu J, Heidarian Y, Mahmoudzadeh NH, Fitt AJ, Absher D, Ding HF, Crossman DK, Placzek WJ, Locasale JW, Rakheja D, McConathy JE, Ramachandran R, Bae S, Tennessen JM, Sudarshan S, J Clin Invest 2024 May
Molecular underpinnings of dedifferentiation and aggressiveness in chromophobe renal cell carcinoma.: Kapur P, Zhong H, Le D, Mukhopadhyay R, Miyata J, Carrillo D, Rakheja D, Rajaram S, Durinck S, Modrusan Z, Brugarolas J, JCI Insight 2024 Apr 9 10

Books

Neuronal ceroid-lipofuscinoses. In Metabolic Diseases: Foundations of Clinical Management, Genetics, and Pathology. 2nd edition

Rakheja D, Bennett MJ (2017). Amsterdam, Netherlands, IOS Press BV

Measurement of oncometabolites D-2-hydroxyglutaric acid and L-2-hydroxyglutaric acid. In Springer Protocols. Methods in Molecular Biology vol 1633. Acute Myeloid Leukemia: Methods and Protocols

Jones PM, Boriack R, Struys EA, Rakheja D (2017). New York, NY, Humana Press, Springer Nature

A Quick Guide to Metabolic Disease Testing Interpretation: Testing for Inborn Errors of Metabolism

Jones P, Patel K, Rakheja D (Ed.) (2020). San Diego, CA, Academic Press, Elsevier

Cholesterol biosynthetic disorders: a review. In Focus on Cholesterol Research

Rakheja D, Rogers BB, Bennett MJ (2006). Hauppauge, NY, Nova Publications

The "fussy" neonate. In Tietz's Applied Laboratory Medicine

Jones PM, Rakheja D (2007). Hoboken, NJ, Wiley-Interscience, John Wiley & Sons Inc.

Quick Guide to Organic Acid Interpretation

Jones PM, Rakheja D (Ed.) (2011). Washington, DC, American Association for Clinical Chemistry Press

The "sleepy" neonate. In Tietz's Applied Laboratory Medicine

Rakheja D, Jones PM (2007). Hoboken, NJ, Wiley-Interscience, John Wiley & Sons Inc.

Glomerular diseases associated with nephritic syndrome and/or rapidly progressive glomerulonephritis. In Silva's Diagnostic Renal Pathology

Rogers T, Rakheja D, Zhou XJ (2009). New York, NY, Cambridge University Press

The aging kidney. In Silva's Diagnostic Renal Pathology

Zhou XJ, Rakheja D, Silva FG (2009). New York, NY, Cambridge University Press

Pathology of germ cell tumors. In Pediatric Germ Cell Tumors

Rakheja D, Teot L (2014). New York, NY, Springer

Basic histopathologic assessment of germ cell tumors for clinic and research. In Springer Protocols. Methods in Molecular Biology vol 2195. Testicular Germ Cell Tumors. Methods and Protocols

Kapur P, Rakheja D (2021). New York, NY, Humana Press, Springer Nature

Honors & Awards

Pediatric Pathology Visiting Scholar, Children's Hospital Boston, Harvard Medical School
(2006)
College of American Pathologists Foundation (CAPF) Scholar
(2004)
Harry B. Neustein Memorial Award, Society for Pediatric Pathology
(2004)
Travel Award for junior investigators, Society for Inherited Metabolic Disorders
(2004)
F. Stephen Vogel Award, United States and Canadian Academy of Pathology
(2003)
Dr. R. P. Mathur Memorial Award in Pathology, Maulana Azad Medical College (Delhi University)
(1997)