Education

Undergraduate
University of Oklahoma Norman (1999)
Graduate School
UT Southwestern Medical Center (2006)

Research Interest

  • Basic Radiation Biology
  • Cellular Response to DNA Damage
  • Intrinsic and Tumor/Cancer Radioresponses
  • The Role of Aberrant DNA Repair and Signaling in Cancer Etiology
  • The Role of the DNA-PK Complex in the Cellular Response to DNA Damage

Publications

Featured Publications LegendFeatured Publications

Imaging of Fluorescently Tagged ATM Kinase at the Sites of DNA Double Strand Breaks.
Davis AJ, Wang SY, Chen DJ, Chen BPC Methods Mol. Biol. 2017 1599 277-285
Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance.
Mori E, Davis AJ, Hasegawa M, Chen DJ Biochem. Biophys. Res. Commun. 2016 Jun
LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.
Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP Nat Commun 2015 6 8325
Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after ?-irradiation and bleomycin treatment.
Abdisalaam S, Davis AJ, Chen DJ, Alexandrakis G Nucleic Acids Res. 2014 Jan 42 1 e5
Complex DSBs: A need for resection.
Davis AJ, Chen DJ Cell Cycle 2014 13 24 3796-7
The amino-terminal region of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is required for its DNA double-strand break-mediated activation.
Davis AJ, Lee KJ, Chen DJ J. Biol. Chem. 2013 Jan
A role for protein phosphatase 4 in regulating non-homologous end-joining.
Davis AJ, Chen DJ Cell Cycle 2012 Oct 11 19 3534-5
Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination.
Shao Z, Davis AJ, Fattah KR, So S, Sun J, Lee KJ, Harrison L, Yang J, Chen DJ DNA Repair (Amst.) 2012 Mar 11 3 310-6
Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex.
Sun J, Lee KJ, Davis AJ, Chen DJ J. Biol. Chem. 2012 Feb 287 7 4936-45
Involvement of the nuclear proteasome activator PA28? in the cellular response to DNA double-strand breaks.
Levy-Barda A, Lerenthal Y, Davis AJ, Chung YM, Essers J, Shao Z, van Vliet N, Chen DJ, Hu MC, Kanaar R, Ziv Y, Shiloh Y Cell Cycle 2011 Dec 10 24 4300-10