University of Oklahoma Norman (1999)
Graduate School
UT Southwestern Medical Center (2006)

Research Interest

  • Basic Radiation Biology
  • Cellular Response to DNA Damage
  • Intrinsic and Tumor/Cancer Radioresponses
  • The Role of Aberrant DNA Repair and Signaling in Cancer Etiology
  • The Role of the DNA-PK Complex in the Cellular Response to DNA Damage


DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining
Head PS, Kapoor-Vazirani P, Nagaraju GP, Zhang H, Rath SK, Luong NC, Haji-Seyed-Javadi R, Sesay F, Wang SY, Duong DM, Daddacha W, Minten EV, Song B, Danelia D, Liu X, Li S, Ortlund EA, Seyfried NT, Smalley DM, Wang Y, Deng X, Dynan WS, El-Rayes B, Davis AJ, Yu DS Nucleic acids research 2023 Aug 51 7972-7987
ATM phosphorylates the FATC domain of DNA-PKcsat threonine 4102 to promote non-homologous end joining
Lu H, Zhang Q, Laverty DJ, Puncheon AC, Augustine MM, Williams GJ, Nagel ZD, Chen PB, Davis AJ Nucleic acids research 2023 Jul 51 6770-6783
DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism
Chen WM, Chiang JC, Shang Z, Palchik G, Newman C, Zhang Y, Davis AJ, Lee H, Chen BP EMBO Journal 2023 Mar 42
DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks
Lu H, Guan J, Wang SY, Li GM, Bohr VA, Davis AJ Nucleic acids research 2022 Jun 50 5635-5651
Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells
Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE Biotechnology and Bioengineering 2022 Mar 119 963-982
Evaluation of the Response of HNSCC Cell Lines to γ-Rays and 12C Ions: Can Radioresistant Tumors Be Identified and Selected for 12C Ion Radiotherapy?
Ding L, Sishc BJ, Polsdofer E, Yordy JS, Facoetti A, Ciocca M, Saha D, Pompos A, Davis AJ, Story MD Frontiers in Oncology 2022 Feb 12
Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma
Saha J, Bae J, Wang SY, Lu H, Chappell LJ, Gopal P, Davis AJ Nucleic acids research 2021 Sep 49 9836-9850
Human RecQ Helicases in DNA Double-Strand Break Repair
Lu H, Davis AJ Frontiers in Cell and Developmental Biology 2021 Feb 9
Erratum: Mechanism of efficient double-strand break repair by a long non-coding RNA (Nucleic Acids Research (2020) 48:19 (10953-10972) DOI: 10.1093/nar/gkaa784)
Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA Nucleic acids research 2021 Jan 49 1199-1200
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM Cancer Cell 2021 Jan 39 109-121.e5