Anthony Davis, Ph.D.

Undergraduate

University of Oklahoma Norman (1999)

Graduate School

UT Southwestern Medical Center (2006)

• Basic Radiation Biology
• Cellular Response to DNA Damage
• Intrinsic and Tumor/Cancer Radioresponses
• The Role of Aberrant DNA Repair and Signaling in Cancer Etiology
• The Role of the DNA-PK Complex in the Cellular Response to DNA Damage

Featured Publications

Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma.

Saha J, Bae J, Wang SY, Lu H, Chappell LJ, Gopal P, Davis AJ, Nucleic Acids Res 2021 Aug

Human RecQ Helicases in DNA Double-Strand Break Repair.

Lu H, Davis AJ, Front Cell Dev Biol 2021 9 640755

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.

Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM, Cancer Cell 2020 Dec

Mechanism of efficient double-strand break repair by a long non-coding RNA.

Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA, Nucleic Acids Res 2020 Oct

DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response.

Lu H, Saha J, Beckmann PJ, Hendrickson EA, Davis AJ, Nucleic Acids Res. 2019 Aug

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

Lu H, Shamanna RA, de Freitas JK, Okur M, Khadka P, Kulikowicz T, Holland PP, Tian J, Croteau DL, Davis AJ, Bohr VA Nat Commun 2017 Dec 8 1 2039

Mechanism of efficient double-strand break repair by a long non-coding RNA.

Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA, Nucleic Acids Res 2020 Dec

HORMAD1 is a negative prognostic indicator in lung adenocarcinoma and specifies resistance to oxidative and genotoxic stress.

Nichols BA, Oswald NW, McMillan EA, McGlynn K, Yan J, Kim MS, Saha J, Mallipeddi PL, LaDuke SA, Villalobos PA, Rodriguez-Canales J, Wistuba II, Posner BA, Davis AJ, Minna JD, MacMillan JB, Whitehurst AW Cancer Res. 2018 Sep

The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer.

Sishc BJ, Davis AJ Cancers (Basel) 2017 Jul 9 7

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair.

Mohamad O, Sishc BJ, Saha J, Pompos A, Rahimi A, Story MD, Davis AJ, Kim DWN Cancers (Basel) 2017 Jun 9 6