Research Interest
  • Interaction between autophagy and Klotho
  • Mineral metabolism (Klotho, FGF23, and phosphate)
  • Renal physiology
  • Role of aberrant Klotho and FGF23 axis in acute kidney injury
  • Role of aberrant of Klotho and FGF23 axis in chronic kidney disease

Publications

Featured Publications LegendFeatured Publications

The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.
Song P, Zechner C, Hernandez G, Cánovas J, Xie Y, Sondhi V, Wagner M, Stadlbauer V, Horvath A, Leber B, Hu MC, Moe OW, Mangelsdorf DJ, Kliewer SA. Cell metabolism. 2018 27 6 1338-1347
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B. Nature 2018 558 7708 136-140.
Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.
Shi M, Flores B, Li P, Gillings N, McMillan KL, Ye J, Huang LJ, Sidhu SS, Zhong YP, Grompe MT, Streeter PR, Moe OW, Hu MC. American journal of physiology. Renal physiology. 2018 314 4 F501-F516.
a-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.
Chen G, Liu Y, Goetz R, Fu L, Jayaraman S, Hu MC, Moe OW, Liang G, Li X, Mohammadi M. Nature. 2018 553 7689 461-466.
Cisplatin nephrotoxicity as a model of chronic kidney disease.
Shi M, McMillan KL, Wu J, Gillings N, Flores B, Moe OW, Hu MC. Lab Invest. 2018 Jun 1. doi: 10.1038/s41374-018-0063-2 2018 doi: 10.1038/s41374-018-0063-2
Recombinant a-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy.
Hu MC, Shi M, Gillings N, Flores B, Takahashi M, Kuro-O M, Moe OW. Kidney international. 2017 91 5 1104-1114.
aKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy.
Shi M, Flores B, Gillings N, Bian A, Cho HJ, Yan S, Liu Y, Levine B, Moe OW, Hu MC. Journal of the American Society of Nephrology 2016 27 8 2331-45
Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling.
Hu MC, Shi M, Cho HJ, Adams-Huet B, Paek J, Hill K, Shelton J, Amaral AP, Faul C, Taniguchi M, Wolf M, Brand M, Takahashi M, Kuro-O M, Hill JA, Moe OW. J Am Soc Nephrol 2015 26 6 [Epub ahead of print]
Klotho has dual protective effects on cisplatin-induced acute kidney injury.
Panesso MC, Shi M, Cho HJ, Paek J, Ye J, Moe OW, Hu MC. Kidney Int. 2014 85 4 855-870
Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.
Hu MC, Shiizaki K, Kuro-o M, Moe OW Annu Rev Physiol. 2013 75:503-33. 503-533