Dr. Xuelian ‘Sue’ Luo received her undergraduate degree in Chemistry from Peking University. She received her Ph.D. in Biochemistry from Tufts University School of Medicine. Her graduate work was mostly focused on biochemical and structural studies of the DNA-binding domain of the SV40 T-antigen and characterization of its interactions with the SV40 origin.
During her postdoctoral work with Gerhard Wagner at Harvard Medical School, Dr. Luo determined the atomic structure of the key spindle checkpoint protein Mad2 by NMR. Due to family reason, she later moved to UT Southwestern and continued her postdoctoral work with Jose Rizo-Rey. Using both NMR and X-ray crystallography, Dr. Luo determined the atomic structures of the multiple conformers of Mad2 and Mad2 in complex with its inhibitor p31comet and showed that a regulated conformational switch of Mad2 is crucial for spindle checkpoint activation. These studies have contributed significantly to our understanding of the mechanisms of chromosome segregation.
Dr. Luo joined the faculty of UT Southwestern in the fall of 2006. Her laboratory is interested in understanding the molecular mechanisms of intracellular signal transduction pathways using a combination of biochemical, structural, and cellular approaches. Her current research efforts focus on the regulation of the Hippo pathway, which controls organ size and maintains tissue homeostasis. Dysregulation of this pathway drives tumor formation in flies, mice, and humans. Dr. Luo’s research has provided critical insights into the activation mechanisms of the core MST-LATS kinase cascade and TEAD-YAP regulation. Her work defines the mechanisms by which MOB1 mediates MST-dependent LATS activation, a central event during Hippo signaling. Her lab recently shows that SAV1 promotes MST kinase activation through antagonizing the STRIPAK PP2A phosphatase. Her research also establishes that TEAD transcription factors undergo functionally important auto-palmitoylation. The discovery that TEAD has enzyme-like activity indicates that TEAD-YAP, which has previously been thought to be undruggable, is in fact an attractive molecular target for cancer therapy. Dr. Luo’s research is aimed to advance our fundamental understanding of the regulation of the Hippo signaling network, and may also uncover novel ways of exploiting defects in the Hippo pathway to treat human diseases.
- Peking University (1990), Chemistry
- Graduate School
- Tufts University (1997), Biochemistry
- Mechanism of Signaling Pathways
- NMR and X-ray Crystallography
- Signal Transduction
- Structural Biology
- The Mad2 spindle checkpoint protein has two distinct natively folded states.
- Luo X, Tang Z, Xia G, Wassmann K, Matsumoto T, Rizo J, Yu H Nat. Struct. Mol. Biol. 2004 Apr 11 4 338-45
- Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing.
- Brulotte ML, Jeong BC, Li F, Li B, Yu EB, Wu Q, Brautigam CA, Yu H, Luo X Nat Commun 2017 Dec 8 1 1956
- Structural basis of cohesin cleavage by separase.
- Lin Z, Luo X, Yu H Nature 2016 Mar
- Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics.
- Ouyang Z, Zheng G, Tomchick DR, Luo X, Yu H Mol. Cell 2016 Mar
- Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.
- Pobbati AV, Han X, Hung AW, Weiguang S, Huda N, Chen GY, Kang C, Chia CS, Luo X, Hong W, Poulsen A Structure 2015 Nov 23 11 2076-86
- The Cdc20-binding Phe Box of the Spindle Checkpoint Protein BubR1 Maintains the Mitotic Checkpoint Complex During Mitosis.
- Diaz-Martinez LA, Tian W, Li B, Warrington R, Jia L, Brautigam CA, Luo X, Yu H J. Biol. Chem. 2015 Jan 290 4 2431-43
- Substrate-Specific Activation of the Mitotic Kinase Bub1 through Intramolecular Autophosphorylation and Kinetochore Targeting.
- Lin Z, Jia L, Tomchick DR, Luo X, Yu H Structure 2014 Oct
- Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
- Sackton KL, Dimova N, Zeng X, Tian W, Zhang M, Sackton TB, Meaders J, Pfaff KL, Sigoillot F, Yu H, Luo X, King RW Nature 2014 Aug
- Mitosis: short-circuiting spindle checkpoint signaling.
- Luo X, Yu H Curr. Biol. 2012 Feb 22 4 R128-30
- Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition.
- Kim S, Sun H, Ball HL, Wassmann K, Luo X, Yu H Proc. Natl. Acad. Sci. U.S.A. 2010 Nov 107 46 19772-7
Honors & Awards
- CPRIT Individual Investigator Research Awards
- National Cancer Institute Howard Temin Award
- American Cancer Society ACS-IRG award
- National Institutes of Health (NIH) Postdoctoral Fellowship
- Giovanni Armenise-Harvard Foundation Postdoctoral Fellow
Harvard Medical School (1997)
- American Society of Biochemistry and Molecular Biology (2015-2019)
- Chinese Biological Investigators Society (2005-2018)