
Chad Brautigam, Ph.D.
Professor
School Medical School
Department Biophysics | Microbiology
Graduate Programs Molecular Biophysics
Education
- Undergraduate
- Uni of Colorado-Boulder (1991), Biochemistry
- Graduate School
- Yale University (1993), Biochemistry
- Graduate School
- Yale University (1998), Biochemistry
Research Interest
- Analytical Ultracentrifugation
- Isothermal Titration Calorimetry
- Protein-protein interactions
- Structural Biology/X-ray Crystallography
- Structural Elucidation of Enzymatic Mechanisms
Publications
Featured Publications
- The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
- Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Zhang X, Chen ZJ Cell Rep 2014 Feb 6 3 421-30
- Sequence, biophysical, and structural analyses of the PstS lipoprotein (BB0215) from Borrelia burgdorferi reveal a likely binding component of an ABC-type phosphate transporter.
- Brautigam CA, Ouyang Z, Deka RK, Norgard MV Protein Sci. 2014 Feb 23 2 200-12
- Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation.
- Zhao H, Brautigam CA, Ghirlando R, Schuck P Curr Protoc Protein Sci 2013 Feb Chapter 20 Unit20.12
- Evidence for an ABC-Type Riboflavin Transporter System in Pathogenic Spirochetes.
- Deka RK, Brautigam CA, Biddy BA, Liu WZ, Norgard MV MBio 2013 4 1
- Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex.
- Brautigam, C.A., Wynn, R.M., Chuang, J.C., Machius, M., Tomchick, D.R., and Chuang, D.T. Structure 2006 14 611-621
- Crystal structure of the photolyase-like domain of Cryptochome 1 from Arabidopsis thaliana.
- Brautigam, C.A., Smith, B.S., Ma, Z., Palnitkar, M., Tomchick, D.R., Machius, M., and Deisenhofer, J. Proc. Natl. Acad. Sci. (USA) 2004 101 12142-12147
- Haemophilus ducreyi Hfq contributes to virulence gene regulation as cells enter stationary phase.
- Gangaiah D, Labandeira-Rey M, Zhang X, Fortney KR, Ellinger S, Zwickl B, Baker B, Liu Y, Janowicz DM, Katz BP, Brautigam CA, Munson RS, Hansen EJ, Spinola SM MBio 2014 5 1 e01081-13
- Improving the Thermal, Radial and Temporal Accuracy of the Analytical Ultracentrifuge through External References.
- Ghirlando R, Balbo A, Piszczek G, Brown PH, Lewis MS, Brautigam CA, Schuck P, Zhao H Anal. Biochem. 2013 May
- Trypanosoma brucei S-Adenosylmethionine Decarboxylase N Terminus Is Essential for Allosteric Activation by the Regulatory Subunit Prozyme.
- Velez N, Brautigam CA, Phillips MA J. Biol. Chem. 2013 Feb 288 7 5232-40
- Multi-signal sedimentation velocity analysis with mass conservation for determining the stoichiometry of protein complexes.
- Brautigam CA, Padrick SB, Schuck P PLoS ONE 2013 8 5 e62694
Honors & Awards
- Magna cum laude
University of Colorado at Boulder (1991) - Phi Beta Kappa
University of Colorado at Boulder (1991) - Williams Family Foundation Scholarship
High School (1987)