Kevin Gardner, Ph.D. Professor School Medical School Department Biochemistry Graduate Programs Biological Chemistry, Molecular Biophysics Biography Please note that this page is not being regularly updated, as the Gardner Lab moved to New York City in fall 2014, where Dr. Gardner directs the Structural Biology Initiative of the CUNY Advanced Science Research Center. For more information, check out the websites for: CUNY ASRC Structural Biology Initiative (https://asrc.gc.cuny.edu/structbio/) • Kevin Gardner laboratory (http://kglab.org) Dr. Gardner joined the UT Southwestern faculty in 1998 after B.S. (UC Davis, 1989), Ph.D. (Yale, 1995) and postdoctoral (Univ. Toronto with Lewis Kay, 1998) studies in biophysics and biochemistry. His research group integrates structural, dynamic and kinetic information from solution NMR studies with other biophysical and biochemical data to probe the signaling mechanisms of environmental sensory proteins. This research aims to decipher how similar proteins sense different stimuli – e.g. blue light, oxygen – to control different output functions. Such studies lay the foundation for both understanding the natural regulation of these systems and artificially controlling them for therapeutic intervention or as biotech tools. Education Undergraduate Uni of California-Davis (1989), Biochemistry Graduate School Yale University (1995), Biochemistry Research Interest allostery artificial regulation biomolecular NMR cancer photosensors signaling structural biology Publications Featured Publications Basis of Mutual Domain Inhibition in a Bacterial Response Regulator. Corrêa F, Gardner KH Cell Chem Biol 2016 Aug Functional and topological diversity of LOV domain photoreceptors. Glantz ST, Carpenter EJ, Melkonian M, Gardner KH, Boyden ES, Wong GK, Chow BY Proc. Natl. Acad. Sci. U.S.A. 2016 Feb Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation. Rivera-Cancel G, Ko WH, Tomchick DR, Correa F, Gardner KH Proc. Natl. Acad. Sci. U.S.A. 2014 Dec An optogenetic gene expression system with rapid activation and deactivation kinetics. Motta-Mena LB, Reade A, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH Nat. Chem. Biol. 2014 Mar 10 3 196-202 Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK Nat. Chem. Biol. 2013 Feb Structural basis of a phototropin light switch. Harper SM, Neil LC, Gardner KH Science 2003 Sep 301 5639 1541-4 On the acquisition and analysis of microscale thermophoresis data. Scheuermann TH, Padrick SB, Gardner KH, Brautigam CA Anal. Biochem. 2015 Dec 496 79-93 Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. Scheuermann TH, Stroud D, Sleet CE, Bayeh L, Shokri C, Wang H, Caldwell CG, Longgood J, MacMillan JB, Bruick RK, Gardner KH, Tambar UK J. Med. Chem. 2015 Jul Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM J. Biomol. NMR 2015 May Ligand-induced folding of a two component signaling receiver domain. Ocasio V, Corrêa F, Gardner KH Biochemistry 2015 Jan Results 1-10 of 82 1 2 3 4 5 Next Last Honors & Awards Southwestern Medical SchoolExcellence in Education Award (2012) UT Southwestern - Postdoctoral AssociationExcellence in Postdoctoral Mentoring Award (2011) Southwestern Medical SchoolExcellence in Education Award (2010) UT Southwestern Medical CenterVirginia Lazenby O’Hara Chair in Biochemistry (2006) The Chicago Community TrustSearle Scholar (1999) UT Southwestern Medical CenterW.W. Caruth, Jr. Scholar in Biomedical Research (1998) Helen Hay Whitney FoundationPostdoctoral Fellowship (1996) NIHNRSA Postdoctoral Fellowship (1995) HHMIPredoctoral Fellowship - Structural Biology (1989) Professional Associations/Affiliations American Chemical Society (1998) Biophysical Society (2005)
