Dr. Liang received his BS in Biochemistry from Peking University in 1991, and his PhD in Biochemistry from The Ohio state University in 1997. Dr. Liang did postdoctoral research in the laboratory of Drs. Michael Brown and Joseph Goldstein at UT Southwestern and worked as a senior scientist at Eli Lilly. In 2005, Dr. Liang returned to UT Southwestern as an assistant professor in the Department of Molecular Genetics.
Dr. Liang is currently professor in Department of Molecular Genetics and Center for Human Nutrition.
- Peking University (1991)
- Graduate School
- Ohio State University-Main Cam (1997)
- Cholesterol homeostasis
- Metabolic diseases such as obesity and diabetes
- Transcriptional regulation
- Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.
- Evers BM, Farooqi MS, Shelton JM, Richardson JA, Goldstein JL, Brown MS, Liang G J. Invest. Dermatol. 2010 May 130 5 1237-48
- Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.
- Zhao TJ, Liang G, Li RL, Xie X, Sleeman MW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Goldstein JL, Brown MS Proc. Natl. Acad. Sci. U.S.A. 2010 Apr 107 16 7467-72
- LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size.
- Okazaki H, Goldstein JL, Brown MS, Liang G J. Biol. Chem. 2010 Feb 285 9 6801-10
- Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice.
- Guan,H.P., Goldstein, J.L., Brown, M.S., and Liang, G. J. Biol. Chem. September 2009 284 24644-52
- 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production.
- Bauman DR, Bitmansour AD, McDonald JG, Thompson BM, Liang G, Russell DW Proc. Natl. Acad. Sci. U.S.A. 2009 Sep 106 39 16764-9
- Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.
- Yang, J., Brown, M.S., Liang, G., Grishin, N.V., Goldstein, J.L. Cell 2008 132 387-396
- Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin
- Engelking, L.J., Evers, B.M., Richardson, J.A., Goldstein, J.L., Brown, M.S. and Liang, G. J. Clin. Invest. September 2006 116 2356-2365
- Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
- Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS. J Clin Invest September 2005 115 (9) 2489-2498
- Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
- Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS. J Clin Invest. September 2005 115(9) 2489-98
- Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.
- Kuriyama H, Liang G, Engelking LJ, Horton JD, Goldstein JL, Brown MS. Cell Metab. January 2005 1(1) 41-51
Honors & Awards
- The Hartwell Individual Biomedical Research Award
- University Fellowship, Ohio State University