Dr. Rege received a BS of Chemical Engineering from Lehigh University in Bethlehem, PA in 1971 and his MD from The Milton S. Hershey Medical School, Pennsylvania State University in Hershey, PA in 1975. Following medical school, he remained at The Milton S. Hershey Medical Center for his first year of residency in General Surgery, and then served 2-years as a general medical officer in the US Navy. He returned to Hershey in 1978 and completed his Residency in Surgery in 1982. After an additional year of training in gastrointestinal research at Northwestern University Medical School, he remained on the faculty at Northwestern. During 15-years at Northwestern, he rose through the academic ranks to the level of Tenured Professor of Surgery, assumed the position of Chief of Surgical Services at the VA Chicago Medical Center, Lakeside Division, and established a busy general surgery practice with an emphasis on complex hepatobiliary and pancreatic surgery. In recent years, Dr. Rege has been a leader in development of advanced laparoscopic surgery, including laparoscopic hernia repair, Nissen fundoplication, esophagomyotomy, colectomy and splenectomy. With the Division of Transplantation Surgery at Northwestern University, he developed the first successful laparoscopic living donor nephrectomy program in the Midwest and taught one of the transplant surgeons the technique. The program now functions independently and harvests more than 100 kidneys each year. He was recruited to UT Southwestern and appointed Professor and Chairman of the Division of Gastrointestinal and Endocrine Surgery in July 1998. In addition, Dr. Rege maintained an active basic research program to study the pathogenesis of gallstones, which has been continuously funded via external sources since its inception in 1983. In April 2001, Dr. Rege was named Chairman of the Department of Surgery and became The Hall and Mary Lucille Shannon Distinguished Professor.


Medical School
Pennsylvania State University College of Medicine (1975)
Milton S. Hershey Medical Center (1976), General Surgery
Milton S. Hershey Medical Center (1982), General Surgery
Northwestern University Medical School (1983), Research

Research Interest

  • Pathogenesis of Gallbladder Diseases


Featured Publications LegendFeatured Publications

Human polymorphonuclear leukocyte phagocytosis of crystalline cholesterol, bilirubin, and calcium hydroxyapatite in vitro.
Prystowsky JB, Huprikar JS, Rademaker AW, Rege RV Dig. Dis. Sci. 1995 Feb 40 2 412-8
Animal models of pigment gallstones.
Rege RV, Dawes LG, Ostrow JD Adv Vet Sci Comp Med 1993 37 257-87
Secretion of biliary calcium is increased in dogs with pigment gallstones.
Dawes LG, Rege RV Dig. Dis. Sci. 1992 Oct 37 10 1523-30
Convective movement of Ca2+ across guinea pig gallbladder epithelium.
Rege RV, Moore EW Am. J. Physiol. 1992 Jun 262 6 Pt 1 G990-5
Canine bile contains anticrystallization factors that inhibit precipitation of calcium carbonate.
Dawes LG, Moore EW, Rege RV, Shimizu S, Ostrow JD Hepatology 1991 Oct 14 4 Pt 1 701-6
Calcium and calcium binding in human gallstone disease.
Dawes LG, Rege RV Arch Surg 1990 Dec 125 12 1606-9
Biliary calcium secretion in the dog occurs primarily by passive convection and diffusion and is linked to bile flow.
Rege RV, Dawes LG, Moore EW J. Lab. Clin. Med. 1990 May 115 5 593-602
Isolation of an acidic protein from cholesterol gallstones, which inhibits the precipitation of calcium carbonate in vitro.
Shimizu S, Sabsay B, Veis A, Ostrow JD, Rege RV, Dawes LG J. Clin. Invest. 1989 Dec 84 6 1990-6
Canine common duct and gallbladder bile contain antinucleating factors that inhibit CaCO3 precipitation.
Rege RV, Dawes LG, Moore EW J. Lab. Clin. Med. 1989 May 113 5 642-50
Reversal of pigment gallstone disease in a canine model.
Dawes LG, Nahrwold DL, Roth SI, Rege RV Arch Surg 1989 Apr 124 4 463-6

Professional Associations/Affiliations

  • Association of VA Surgeons, President 2003-2004
  • Fellow of the American College of Surgeons
  • Society of American Gastrointestinal Endoscopic Surgeons
  • Society of Surgical Chairmen
  • Texas Surgical Society