Dr. Rege received a BS of Chemical Engineering from Lehigh University in Bethlehem, PA in 1971 and his MD from The Milton S. Hershey Medical School, Pennsylvania State University in Hershey, PA in 1975. Following medical school, he remained at The Milton S. Hershey Medical Center for his first year of residency in General Surgery, and then served 2-years as a general medical officer in the US Navy. He returned to Hershey in 1978 and completed his Residency in Surgery in 1982. After an additional year of training in gastrointestinal research at Northwestern University Medical School, he remained on the faculty at Northwestern. During 15-years at Northwestern, he rose through the academic ranks to the level of Tenured Professor of Surgery, assumed the position of Chief of Surgical Services at the VA Chicago Medical Center, Lakeside Division, and established a busy general surgery practice with an emphasis on complex hepatobiliary and pancreatic surgery. In recent years, Dr. Rege has been a leader in development of advanced laparoscopic surgery, including laparoscopic hernia repair, Nissen fundoplication, esophagomyotomy, colectomy and splenectomy. With the Division of Transplantation Surgery at Northwestern University, he developed the first successful laparoscopic living donor nephrectomy program in the Midwest and taught one of the transplant surgeons the technique. The program now functions independently and harvests more than 100 kidneys each year. He was recruited to UT Southwestern and appointed Professor and Chairman of the Division of Gastrointestinal and Endocrine Surgery in July 1998. In addition, Dr. Rege maintained an active basic research program to study the pathogenesis of gallstones, which has been continuously funded via external sources since its inception in 1983. In April 2001, Dr. Rege was named Chairman of the Department of Surgery and became The Hall and Mary Lucille Shannon Distinguished Professor.


Medical School
Pennsylvania State University College of Medicine (1975)
Milton S. Hershey Medical Center (1976), General Surgery
Milton S. Hershey Medical Center (1982), General Surgery
Northwestern University Medical School (1983), Research

Research Interest

  • Pathogenesis of Gallbladder Diseases


Featured Publications LegendFeatured Publications

Bilateral adrenal cortical adenomas in primary hyperaldosteronism.
Engel JD, Angelos P, Rege RV, Joehl RJ Urology 1998 Oct 52 4 711-4
The inflammatory effects of crystalline cholesterol monohydrate in the guinea pig gallbladder in vivo.
Prystowsky JB, Rege RV Surgery 1998 Mar 123 3 258-63
Inflammation and a thickened mucus layer in mice with cholesterol gallstones.
Rege RV, Prystowsky JB J. Surg. Res. 1998 Jan 74 1 81-5
Interleukin-1 mediates guinea pig gallbladder inflammation in vivo.
Prystowsky JB, Rege RV J. Surg. Res. 1997 Aug 71 2 123-6
Neurogenic inflammation in cholecystitis.
Prystowsky JB, Rege RV Dig. Dis. Sci. 1997 Jul 42 7 1489-94
Laparoscopic splenectomy.
Rege RV, Merriam LT, Joehl RJ Surg. Clin. North Am. 1996 Jun 76 3 459-68
Methionine, but not taurine, protects against formation of canine pigment gallstones.
Christian JS, Rege RV J. Surg. Res. 1996 Feb 61 1 275-81
Hypercholeresis with cholate infusion in dogs with pigment gallstones.
Matsumura J, Neri K, Rege RV Dig. Dis. Sci. 1996 Feb 41 2 272-81
Inflammatory properties of bile from dogs with pigment gallstones.
Rege RV, Prystowsky JB Am. J. Surg. 1996 Jan 171 1 197-201
Adverse effects of biliary obstruction: implications for treatment of patients with obstructive jaundice.
Rege RV AJR Am J Roentgenol 1995 Feb 164 2 287-93

Professional Associations/Affiliations

  • Association of VA Surgeons, President 2003-2004
  • Fellow of the American College of Surgeons
  • Society of American Gastrointestinal Endoscopic Surgeons
  • Society of Surgical Chairmen
  • Texas Surgical Society