Venkateswara Mootha, M.D.

Professor

Endowed Title: Paul T. Stoffel / Centex Professorship in Clinical Care
School: Medical School
Department: Ophthalmology | Eugene McDermott Center for Human Growth and Development
Graduate Programs: Genetics, Development and Disease

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For more information on the doctor and patient care, please visit the clinical profile.

Education

Medical School: Johns Hopkins University School of Medicine (1993)
Internship: St. Joseph's Hospital (1994), Transitional Year
Residency: University of Wisconsin Hospital and Clinics (1997), Ophthalmology
Fellowship: UT Southwestern Medical School (1999), Cornea & External Diseases

Research Interest

Publications

Featured Publications

Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease.: Chu Y, Hu J, Liang H, Kanchwala M, Xing C, Beebe W, Bowman CB, Gong X, Corey DR, Mootha VV, Nucleic Acids Res. 2020 May
Delivery of Antisense Oligonucleotides to the Cornea.: Chau VQ, Hu J, Gong X, Hulleman JD, Ufret-Vincenty RL, Rigo F, Prakash TP, Corey DR, Mootha VV, Nucleic Acid Ther 2020 Mar
Oligonucleotides Targeting TCF4 Triplet Repeat Expansion Inhibit RNA Foci and Mis-splicing in Fuchs' Dystrophy.: Hu J, Rong Z, Gong X, Zhou Z, Sharma VK, Xing C, Watts JK, Corey DR, Mootha VV Hum. Mol. Genet. 2018 Jan
Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy.: Mootha VV, Hansen B, Rong Z, Mammen PP, Zhou Z, Xing C, Gong X Invest. Ophthalmol. Vis. Sci. 2017 Sep 58 11 4579-4585
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy.: Afshari NA, Igo RP, Morris NJ, Stambolian D, Sharma S, Pulagam VL, Dunn S, Stamler JF, Truitt BJ, Rimmler J, Kuot A, Croasdale CR, Qin X, Burdon KP, Riazuddin SA, Mills R, Klebe S, Minear MA, Zhao J, Balajonda E, Rosenwasser GO, Baratz KH, Mootha VV, Patel SV, Gregory SG, Bailey-Wilson JE, Price MO, Price FW, Craig JE, Fingert JH, Gottsch JD, Aldave AJ, Klintworth GK, Lass JH, Li YJ, Iyengar SK Nat Commun 2017 Mar 8 14898
Congenital Corneal Endothelial Dystrophies Resulting From Novel De Novo Mutations.: Cunnusamy K, Bowman CB, Beebe W, Gong X, Hogan RN, Mootha VV Cornea 2016 Feb 35 2 281-5
A novel H395R mutation in MKKS/BBS6 causes retinitis pigmentosa and polydactyly without other findings of Bardet-Biedl or McKusick-Kaufman syndrome.: Hulleman JD, Nguyen A, Ramprasad VL, Murugan S, Gupta R, Mahindrakar A, Angara R, Sankurathri C, Mootha VV Mol. Vis. 2016 22 73-81
Correlation of Severity of Fuchs Endothelial Corneal Dystrophy With Triplet Repeat Expansion in TCF4.: Soliman AZ, Xing C, Radwan SH, Gong X, Mootha VV JAMA Ophthalmol 2015 Sep 1-6
TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy.: Mootha VV, Hussain I, Cunnusamy K, Graham E, Gong X, Neelam S, Xing C, Kittler R, Petroll WM Invest. Ophthalmol. Vis. Sci. 2015 Feb
Impact of Donor Age on Corneal Endothelium-Descemet Membrane Layer Scroll Formation.: Bennett A, Mahmoud S, Drury D, Cavanagh HD, McCulley JP, Petroll WM, Mootha VV Eye Contact Lens 2015 Jan

Honors & Awards

Achievement Award
American Academy of Ophthalmology (2020)
Top Award, $50,000 grant in the UT Southwestern Biotech Track of the Big Idea Competition
UT Dallas Institute for Innovation and Entrepreneurship and Texas Startups Roadshow (2020)
Harrington Scholar-Innovator Award
Harrington Discovery Institute (2018)
Cornea Society
Member with thesis (2010)
North & Central Texas Clinical and Translational Science Initiative
Pilot Grant Award Recipient (2010)

Professional Associations/Affiliations