Venkateswara Mootha, M.D.

Professor

Endowed Title: Paul T. Stoffel / Centex Professorship in Clinical Care
School: Graduate School
Department: Ophthalmology | Eugene McDermott Center for Human Growth and Development
Graduate Programs: Genetics, Development and Disease

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For more information on the doctor and patient care, please visit the clinical profile.

Education

Medical School: Johns Hopkins University School of Medicine (1993)
Internship: St. Joseph's Hospital (1994), Transitional Year
Residency: University of Wisconsin Hospital and Clinics (1997), Ophthalmology
Fellowship: UT Southwestern Medical School (1999), Cornea & External Diseases

Research Interest

Cataract surgery
Endothelial keratoplasty
Fuchs' Endothelial Corneal Dystrophy
Genetics of corneal disorders
Repeat RNA in Age-Related Degenerative Disease

Publications

Bayesian Analysis of Valacyclovir Treatment Effect in the Zoster Eye Disease Study: Jeng BH, Lee TF, Troxel AB, Lu Y, Cohen EJ, Kim J, Hochman JS, Weissbart SB, Abazari A, Chou TY, Chang E, Amescua G, Tonk R, Koo E, Martinez JD, Galor A, Patel SV, Berestka JS, Nanji AA, Chamberlain W, Stutzman R, Clements J, Chodosh J, Davies EC, Saeed H, Ciralsky JB, Alzaga Fernandez AG, Sippel KC, Perez-Quinones VL, Daluvoy M, Liu K, Ewald MD, Groos EB, Chang B, Shivitz IA, Hill J, Fowler PG, Read RW, Geggel HS, Omar A, Rony S, Rapuano CJ, Meghpara B, Syed Z, Holland GN, Lee O, Irvine J, Deng SX, Aldave A, Edmund T, Chen J, Honig MA, Snyder LA, Huang AJ, Margolis TP, Lubniewski A, Katz DG, Capoor S, Gonzales J, Seitzman G, Keenan J, Morkin M, Kenyon KR, Hamrah P, Lee WB, Christenbury JG, LaMattina KC, Lee H, Negahban K, Rao R, Ament CS, Lopatynsky MO, Barbato JD, Sarkar JS, Macsai M, Herz JB, Weikert MP, Al-Mohtaseb Z, Matoba AY, Cooney T, Hood C, Woodward M, Sugar A, Shtein RM, Nehls SM, Warner EJ, Nettune G, Bowman B, Gelender H, Alexander JK, McCall T, Zaffos J, Beebe W, Potts LB, Lustbader J, Oboh-Weilke AM, Hammersmith KM, Orlin SE, Nagra P, Sulewski M, Bunya V, Shafer B, Prescott CR, Haberman I, Viriya E, Qureshi A, Lazzaro D, Palazzolo L, Goyal H, Schrack KE, Raber IM, Ayres B, Finklea B, Reeves S, Awad OE, Hardten DR, Reilly CD, Flynn WJ, Rashid ED, Wen AE, Ritterband DC, Harris DJ, Ahmad S, Shaik N, Seedor JA, Rosenfeld SI, Winnick M, Amir A, Sherman MD, Srikumaran D, Akpek E, Chaon B, Soukiasian SH, Rao NK, Steiner AS, Winokur J, Udell I, Shih C, Gorski M, Schrier A, Lobo-Chan AM, Sugar J, Tu E, Munir WW, Sunshine S, Miller DM, Gensheimer WG, Zegans ME, Weiss JS, Bernal M, Barron B, Hindman HB, Wise R, Gelston C, Taravella MJ, Davidson RS, Tran UL, Shieh C, Bartley J, McCulley J, Verity S, Bowman W, Blomquist P, Mootha VV, Thorne G, Renucci AM, Verdier D, Sivaraman K, Nordlund M, Hwang FS, Affeldt J, Ingraham H, Guibord NM, Dobbins KR, Thareja T, Lin A, Zaugg B, Mifflin M, Forstot SL, Fish RA, Repine K, Wildes M, Estopinal CB, Brown D, Koreishi A, Ple-Plakon P, Clemons CS, Patel R, Asbell PA, Ashe SA, Bonaffini S, Houser K, Wallace M, Wesberry JM, Iovieno A, Yeung SN, Teichman JC, Noordeh N, Faucher A, Robert MC, Harissi-Dagher M, Rullo J, Baxter S, Johnson D, Mah D, Benson M, Tone SO, Chew H, Hassonlou M, Liu S, Eikenberry JL, Yung CW, Shen JF, Lin C, Yu C, Ta C, Goins KR, Sutphin J, Svanda K, Keppol S, Rostov A, Vyas NM, Hsu K, Goodman G, McHam L, Oates D, Rizkalla R, Shukla A, Veena M, See C, Goshe J, Feder RS, Baqai J, Basti S, Haddadin R, You JY, Dixit LA, Patel RH, Golde KT, Zaidman GW, Mahesh S, Sharma V, Wesolosky J, Miller DD, Ma JH, Mannis M, Meyer JJ, Niederer R, Colby KA, McLeod S, Melia M, Sugar E, Taylor CR, Nagel M, Dupps WJ, Lass JH, Bajart A, Farooq A, Hofmeister E, Kaufman A, Rhee M, Yoo J Ophthalmology 2026 Jan 133 151-153
Delphi-Based Global Consensus on Fuchs Endothelial Corneal Dystrophy. An Endothelial Keratoplasty Learners Group Initiative: Patel SV, Gupta N, Bhogal M, Jurkunas UV, Okumura N, Romano V, Allan BD, Baratz KH, Basak SK, Baydoun L, Chamberlain W, Chaurasia S, Colby K, Cursiefen C, Giobellina T, Greiner MA, Hjortdal J, Kobayashi A, Kocaba V, Koo EH, Lee WB, Livny E, Males JJ, Matthaei M, Mehta JS, Mejia L, Moloney G, Mootha VV, Muraine M, Oie Y, Pereira NC, Price FW, Srikumaran D, Terry MA, Veldman PB, Verdier DD, Vaddavalli PK, Pineda R American journal of ophthalmology 2025 Dec 280 130-143
Assessment of Early Fuchs Endothelial Corneal Dystrophy and CTG Trinucleotide Expansion Positivity Using Scheimpflug Imaging: Poh SS, Tey KY, Peh GS, Neo DJ, Htoon HM, Lee EK, Soh YQ, Mootha VV, Mehta JS Ophthalmology Science 2025 Sep 5
Transcriptomic analysis implicates the involvement of RBM20 in Fuchs’ endothelial corneal dystrophy with TCF4 repeat expansion: Zhang X, Yu Z, Westfall AK, Han K, Mootha VV, Xing C PloS one 2025 Sep 20
Increased Risk of Glaucoma in Fuchs Endothelial Corneal Dystrophy Is Independent of TCF4 Trinucleotide Repeat Expansion: Xing C, Schultis S, Bondar V, Gong X, Whitson JT, Mootha VV Cornea 2025 Aug 44 961-964
Modulation of TTR gene expression in the eye using modified siRNAs: Hu J, Gong X, Kundu J, Datta D, Egli M, Manoharan M, Mootha VV, Corey DR Nucleic acids research 2025 May 53
Low-Dose Valacyclovir for Postherpetic Neuralgia in the Zoster Eye Disease Study: A Randomized Clinical Trial: Author Collaboration ZT, Warner DB, Jeng BH, Kim J, Liu M, Troxel AB, Hochman JS, Baratz KH, Mian SI, Choulakian MY, Meyer JJ, Lu Y, Twi-Yeboah A, Lee TF, Lopez-Jimenez C, Laury SC, Cohen EJ, Weissbart SB, Abazari A, Chou TY, Chang E, Amescua G, Tonk R, Koo E, Martinez JD, Galor A, Patel SV, Berestka JS, Nanji AA, Chamberlain W, Stutzman R, Clements J, Chodosh J, Davies EC, Saeed H, Ciralsky JB, Alzaga Fernandez AG, Sippel KC, Perez-Quinones VL, Daluvoy M, Liu K, Ewald MD, Groos EB, Chang B, Shivitz IA, Hill J, Bartley J, McCulley J, Verity S, Blomquist P, Mootha VV JAMA Ophthalmology 2025 Apr 143 277-285
Low-Dose Valacyclovir in Herpes Zoster Ophthalmicus: The Zoster Eye Disease Randomized Clinical Trial: Author Collaboration ZT, Cohen EJ, Troxel AB, Liu M, Hochman JS, Baratz KH, Mian SI, Choulakian MY, Warner DB, Lu Y, Twi-Yeboah A, Lee TF, Kim J, Lopez-Jimenez C, Laury SC, Jeng BH, Weissbart SB, Abazari A, Chou TY, Chang E, Amescua G, Tonk R, Koo E, Martinez JD, Galor A, Patel SV, Berestka JS, Nanji AA, Chamberlain W, Stutzman R, Clements J, Chodosh J, Davies EC, Saeed H, Ciralsky JB, Alzaga Fernandez AG, Sippel KC, Perez-Quinones VL, Daluvoy M, Liu K, Ewald MD, Groos EB, Chang B, Shivitz IA, Hill J, Fowler PG, Bartley J, McCulley J, Verity S, Blomquist P, Mootha VV JAMA Ophthalmology 2025 Apr 143 269-276
Prevalence of Transcription Factor 4 Gene Triplet Repeat Expansion Associated with Fuchs’ Endothelial Corneal Dystrophy in the United States and Global Populations: Zhang X, Kumar A, Gong X, Xing C, Mootha VV Ophthalmology Science 2025 Jan 5
Genetic disorders of the cornea: Bakr MA, Tu E, Sugar J, Mootha VV 2024 Jan 345-384

Honors & Awards

Achievement Award
American Academy of Ophthalmology (2020)
Top Award, $50,000 grant in the UT Southwestern Biotech Track of the Big Idea Competition
UT Dallas Institute for Innovation and Entrepreneurship and Texas Startups Roadshow (2020)
Harrington Scholar-Innovator Award
Harrington Discovery Institute (2018)
Cornea Society
Member with thesis (2010)
North & Central Texas Clinical and Translational Science Initiative
Pilot Grant Award Recipient (2010)

Professional Associations/Affiliations

American Academy of Ophthalmology
Association for Research in Vision and Ophthalmology