Biography

Dr. Engelking is originally from Houston, Texas and first came to UT Southwestern for joint MD/PhD training (2000-2007), where he studied cholesterol and fat metabolism under the tutelage of Nobel Laureates Goldstein and Brown. He then completed his clinical training in internal medicine at Massachusetts General Hospital (2007-2010), an affiliate of Harvard Medical School.  Drawn by the opportunity to study lipid metabolism in the intestine, he returned to UT Southwestern for clinical and research fellowships in gastroenterology and hepatology (2010-2014) and thereafter joined the faculty of the Departments of Internal Medicine (Division of Digestive and Liver Diseases) and Molecular Genetics along with the Center for Human Nutrition. His current research interests include understanding the roles that lipids, particularly cholesterol, play in the growth of intestinal cells both in normal health and in states of uncontrolled growth, such as intestinal cancers like colorectal cancer. He practices adult gastroenterology and serves as a teaching attending of fellows, residents, and students at Parkland Memorial Hospital.  He also serves as the director of the GI Genetics Clinic at Parkland, a clinic subspecialized in the care of patients with inherited disorders of polyposis and colorectal cancer, particularly Lynch syndrome and Familial Adenomatous Polyposis syndrome.

Education

Medical School
UT Southwestern Medical School (2007)
Residency
Massachusetts General Hospital (2010), Internal Medicine
Fellowship
UT Southwestern Medical Center (2014), Gastroenterology

Research Interest

  • Cholesterol and Fat Metabolism
  • Inherited Colon Cancer and Polyposis Syndromes, Lynch Syndrome, Familial Adenomatous Polyposis Syndrome
  • Intestinal Stem Cell Function
  • SREBP, Scap and Insig Proteins

Publications

Featured Publications LegendFeatured Publications

Interplay between ChREBP and SREBP-1c Coordinates Postprandial Glycolysis and Lipogenesis in Livers of Mice.
Linden AG, Li S, Choi HY, Fang F, Fukasawa M, Uyeda K, Hammer RE, Horton JD, Engelking LJ, Liang G J. Lipid Res. 2018 Jan
Developmental and extrahepatic physiological functions of SREBP pathway genes in mice.
Engelking LJ, Cantoria MJ, Xu Y, Liang G Semin. Cell Dev. Biol. 2017 Jul
Hypoxia-inducible factor-1a activates insig-2 transcription for degradation of HMG CoA reductase in the liver.
Hwang S, Nguyen AD, Jo Y, Engelking LJ, Brugarolas J, DeBose-Boyd RA J. Biol. Chem. 2017 Apr
Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.
McFarlane MR, Liang G, Engelking LJ J. Biol. Chem. 2014 Jan 289 4 2148-56
Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes.
Engelking LJ, McFarlane MR, Li CK, Liang G J. Lipid Res. 2012 Jul 53 7 1359-68

Honors & Awards

  • Disease-Oriented Clinical Scholar
    UT Southwestern (2014)
  • Distinguished Researcher's Award
    President's Research Council (2014)
  • Research Scholar in Liver Disease
    North American Gilead Sciences (2014)
  • Alpha Omega Alpha Honor Medical Society
    UT Southwestern (2007)
  • Summa cum laude
    Texas A&M University (2000)
  • University Honors
    Texas A&M University (2000)
  • University Undergraduate Research Fellow
    Texas A&M University (2000)

Professional Associations/Affiliations

  • American Gastroenterological Association (2010)
  • American Society for Biochemistry and Molecular Biology (2010)