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Lina Chalak, M.D.

Lina Chalak, M.D.

Titles and Appointments

Chief, Division of Neonatal-perinatal Medicine

Professor & Division Chief

Endowed Title
The William Buchanan Chair in Pediatrics
School
Medical School
Department
Pediatrics | Psychiatry

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For more information on the doctor and patient care, please visit the clinical profile.

  • Biography

    Lina Chalak, M.D., M.S.C.S., is a Professor in the Departments of Pediatrics and Psychiatry at UT Southwestern Medical Center. She is the founding director of the Neurointensive Care program and of the Fetal Neonatal Neurology Fellowship Program. Board certified in general pediatrics, general pediatrics recertification, neonatal-perinatal medicine, and neonatal-perinatal recertification, Dr. Chalak joined the UT Southwestern faculty in 2008. 

    Dr. Chalak earned her medical degree and completed a residency in pediatrics at American University of Beirut. She subsequently completed fellowships in both neonatal-perinatal medicine and pediatrics at UT Southwestern/Children’s Health Dallas. In 2011, she received a Master of Clinical Science Distinction from UT Southwestern’s Graduate School of Biomedical Sciences.  

    An active physician-scientist, Dr. Chalak’s research focuses on asphyxia, hypothermia, and neonatal brain injury. The recipient of multiple federally funded awards, her current projects include: cerebrovascular autoregulation and neuronal biomarkers in HIE, as well as neuronal and inflammatory biomarkers involved in neuronal injury pathways. She has led the PRIME mild asphyxia collaborative study and pioneered a “Neurovascular bundle” for a critical real time evaluation of the coupling of cerebral blood flow and neuronal activity in newborns with asphyxia She leads a multi-science research team of physiologists, biomedical engineers with a novel neurovascular bundle for evaluation of the coupling of cerebral blood flow and neuronal activity. She serves on NIH sections, American Pediatric Society (APS) and society of pediatric research SPR executive council. 

     

  • Education
    Medical School
    American University - Beirut (1995)
    Internship
    American University of Beruit (1996), Pediatrics
    Residency
    American University of Beruit (1998), Pediatrics
    Fellowship
    UT Southwestern Medical Center (2001), Neonatal-perinatal Medicine
    Internship
    Children's Medical Center Dallas (2002), Pediatrics
    Residency
    Children's Medical Center Dallas (2004), Pediatrics
    Other Post Graduate Training
    UT Southwestern Medical Center (2011)
    Graduate School
    UT Southwestern Medical Center (2011)
  • Research Interest
    • Asphyxia
    • Hypothermia
    • Neonatal brain injury
  • Publications
    Placental inflammatory response and association with the severity of neonatal hypoxic ischemic encephalopathy
    Mashat S, Bitar L, Mir IN, Leon RL, Brown LS, Chalak LF Early Human Development 2025 Feb 201
    Web-based training and certification of clinical staff during the randomised clinical trial SafeBoosC-III
    Author Collaboration ST, Rasmussen MI, Hansen ML, Peters C, Greisen G, Yin Z, Peng Z, Vesoulis Z, Xu X, Gao X, Karadyova V, Nordvik T, Szczapa T, Karen T, Marciniak S, Oguz S, Fredly S, Kersin SG, Hyttel-Sørensen S, Pisoni S, Zeng S, Rao SA, Suna S, Nesargi S, Borregas SP, Lauterbach R, del Rio Florentino R, Sanchez-Salmador R, Maton P, Korcek P, Agergaard P, Zafra P, Baud O, Vaccarello OO, Koksal N, Baş M, Akin MS, Kadri MM, Fumagalli M, Alsina M, Cetinkaya M, Agosti M, Stocker M, Palacio MT, Ybarra MM, Baserga M, Wilinska M, Arruza L, Cornette L, Yang L, Chalak L Trials 2024 Dec 25
    Placental pathology in SARS-CoV-2 infected pregnancies: A single-institution retrospective cohort analysis
    Le T, Lee D, Brown LS, Payton BW, Sepulveda P, Sisman J, Leon RL, Chalak LF, Mir IN Journal of Neonatal-Perinatal Medicine 2024 Oct 17 623-636
    Brain Injury Outcomes after Adjuvant Erythropoietin Neuroprotection for Moderate or Severe Neonatal Hypoxic-Ischemic Encephalopathy: A Report from the HEAL Trial
    Author Collaboration TH, Wisnowski JL, Monsell SE, Bluml S, Goodman AM, Li Y, Comstock BA, Heagerty PJ, Juul SE, Wu YW, Mckinstry RC, Mathur AM, Ahmed K, Chen PS, Dix J, Bendel-Stenzel E, Lampland A, Patterson R, Ramos YM, Chang T, Fricke S, Whitehead M, Wu TW, Yanowitz T, Panigrahy A, Flibotte J, Berman J, Vossough A, Poindexter B, Tkach J, KlineFath B, Riley D, Head HW, Maitre N, Smith M, Rusin J, Beserga M, Oveson M, Rampton J, Mietzsch U, Sokol GM, Ho CY, Mayock D, Friedman S, Shaw D, Van Meurs K, Vasanawala S, Yeom K, Gonzalez F, Chalak L, Rollins N Developmental Neuroscience 2024 Oct 46 285-296
    Reverse Therapy: Impact of Hyperthermia and Rewarming on Newborn Outcomes
    Chalak LF, Davidson JO, Gunn AJ Clinics in Perinatology 2024 Sep 51 565-572
    Moving the Needle in Perinatal Asphyxia
    Chalak LF Clinics in Perinatology 2024 Sep 51 xxi-xxiii
    A New Horizon for Understanding the Comparative Effectiveness for Cooling Prospectively Infants with Mild Encephalopathy
    Chalak LF, Slaughter JL, King WC, Sepulveda P, Wisniewski SR Clinics in Perinatology 2024 Sep 51 605-616
    Key Inflammatory Biomarkers in Perinatal Asphyxia: A Comprehensive Review
    Bitar L, Stonestreet BS, Chalak LF Clinics in Perinatology 2024 Sep 51 617-628
    Prognostic value of quantitative EEG in early hours of life for neonatal encephalopathy and neurodevelopmental outcomes
    Kota S, Kang S, Liu YL, Liu H, Montazeri S, Vanhatalo S, Chalak LF Pediatric Research 2024 Aug 96 685-694
    Perinatal asphyxia impact on networks of cortical activity
    Kota S, Chalak L Pediatric Research 2024 Jul 96 17-18
  • Honors & Awards
    • Executive Leadership
      Executive Leadership in Academic Medicine (2023)
    • Executive Council Society of Pediatric Research
      (2020)
    • Program Development Award Nomination Fetal/Neonatal Neurological Program
      UT Southwestern Medical Center-Leaders in Clinical Excellence (2020)
    • Acarin Award for Outstanding Presentation
      10th Hershey Conference Equivilly, France (2016)
    • Elected member, International Perinatal Collegium
      (2015)
    • Elected member, The Perinatal Research Society
      (2014)
    • Elected member, Society of Pediatric Research
      (2011)
    • PRS Young Research Investigator Award
      Perinatal Research Society (2010)
    • Dean's Teaching Award for Education
      Department of Pediatrics at the University of Arkansas, Little Rock, AR (2007-2008)
    • Best Teacher Award
      Department of Pediatrics at the University of Arkansas, Little Rock, AR (2006-2007)
    • Educator of the Year
      Department of Pediatrics at the University of Arkansas, Little Rock, AR (2005-2006)
    • AAP Young Investigator Award
      AAP (2004)
  • Professional Associations/Affiliations
    • American Pediatric Society (2019)
    • International Perinatal Collegium (2015)
    • Newborn Brain Society (2019)
    • Perinatal Research Society (2014)
    • Society for Pediatric Research (2011)
    • SPR Executive Council-Lead for Education and Scientific Programs (2020)