Jef De Brabander, Ph.D. Professor Endowed Title Julie and Louis Beecherl Jr. Chair in Medical Science School Medical School Department Radiation Oncology | Biochemistry | Harold C. Simmons Comprehensive Cancer Center Graduate Programs Organic Chemistry Biography Jef K. De Brabander is a native of Belgium, where he pursued his undergraduate and graduate studies at the University of Gent. Following postdoctoral studies with the late Wolfgang Oppolzer at the University of Geneva and Paul Wender at Stanford University, he began his independent career as a junior faculty member at the University of Geneva. After one year, he was recruited to UT Southwestern , where he was promoted to full Professor in 2007. Jef De Brabander was an Alfred P. Sloan Foundation Fellow from 2001-2003, and serves on the Scientific Advisory Board of Reata Pharmaceuticals, a company he co-founded. Education Graduate School Universiteit Gent (1993), Chemistry Research Interest Integration of molecular pharmacology and biochemistry Synthesis of complex, naturally occurring, molecular architectures Publications Featured Publications Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A X. Jiang, B. Liu, S. Lebreton, J. K. De Brabander Journal of the American Chemical Society 2007 129 6386-6387 A Small Molecule Smac Mimic Potentiates TRAIL- and TNFa-Mediated Cell Death. Lin Li, Ranny Mathew Thomas, Hidetaka Suzuki, Jef K. De Brabander, Xiaodong Wang, Patrick G. Harran Science September 2004 305 1471-1474 Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A1. ? Xie X-S, Padron-Perez D, Liao X, Wang J, Roth MG, De Brabander JK J. Biol. Chem. 2004 279 19755-19763 Total Synthesis and Absolute Configuration of the Novel Microtubule Stabilizing Agent Peloruside A Liao X, Wu Y, De Brabander JK Angew. Chem. Int. Ed. 2003 42 1648-1652 Total Synthesis and Initial StructureFunction Analysis of the potent V-ATPase Inhibitors Salicylihalamide A and Related Compounds Wu Y, Liao X, Wang R, Xie X-S, De Brabander JK J. Am. Chem. Soc. 2002 124 3245-3253 Au(I)- and Pt(II)-Catalyzed Cycloetherification of Omega-Hydroxy Propargylic Esters J. K. De Brabander, B. Liu, M. Qian Organic Letters 2008 10 2533-2536 Synthesis of Psymberin Analogs: Probing a Functional Correlation with the Pederin/Mycalamide Family of Natural Products. Jiang, X; Williams, N.; De Brabander, J. K. Org. Lett. 2007 9 227-230 Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals. Liu, B. and De Brabander, J.K. Org. Lett. 2006 8 4907-4010 Synthesis of Spirastrellolide A Fragments for Structure Elucidation Pan, Y.; De Brabander, J. K. Synlett 2006 853-856 Synthesis and Complete Stereochemical Assignment of Psymberin / Irciniastatin A. Journal of the American Chemical Society 127, 11254-11255 Jiang, X.; Garcia-Fortanet, J.; De Brabander, J. K. J. Am. Chem. Soc. 2005 127 11254-11255 Results 1-10 of 10 1 Honors & Awards Alfred P. SloanResearch Fellowship (2001) Fulbright-HaysAward (1995) NATOFellowship (1995) Swiss National Science FoundationFellowship (1994) Institute for Scientific Research in Agriculture and IndustryScholarship (1989) Professional Associations/Affiliations American Association for the Advancement of Science American Chemical Society
