Jef K. De Brabander is a native of Belgium, where he pursued his undergraduate and graduate studies at the University of Gent. Following postdoctoral studies with the late Wolfgang Oppolzer at the University of Geneva and Paul Wender at Stanford University, he began his independent career as a junior faculty member at the University of Geneva.

After one year, he was recruited to UT Southwestern , where he was promoted to full Professor in 2007. Jef De Brabander was an Alfred P. Sloan Foundation Fellow from 2001-2003, and serves on the Scientific Advisory Board of Reata Pharmaceuticals, a company he co-founded.


Graduate School
Universiteit Gent (1993), Chemistry

Research Interest

  • Integration of molecular pharmacology and biochemistry
  • Synthesis of complex, naturally occurring, molecular architectures


Featured Publications LegendFeatured Publications

Au(I)- and Pt(II)-Catalyzed Cycloetherification of Omega-Hydroxy Propargylic Esters
J. K. De Brabander, B. Liu, M. Qian Organic Letters 2008 10 2533-2536
Synthesis of Psymberin Analogs: Probing a Functional Correlation with the Pederin/Mycalamide Family of Natural Products.
Jiang, X; Williams, N.; De Brabander, J. K. Org. Lett. 2007 9 227-230
Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals.
Liu, B. and De Brabander, J.K. Org. Lett. 2006 8 4907-4010
Synthesis of Spirastrellolide A Fragments for Structure Elucidation
Pan, Y.; De Brabander, J. K. Synlett 2006 853-856
Synthesis and Complete Stereochemical Assignment of Psymberin / Irciniastatin A. Journal of the American Chemical Society 127, 11254-11255
Jiang, X.; Garcia-Fortanet, J.; De Brabander, J. K. J. Am. Chem. Soc. 2005 127 11254-11255

Honors & Awards

  • Alfred P. Sloan
    Research Fellowship (2001)
  • Fulbright-Hays
    Award (1995)
  • NATO
    Fellowship (1995)
  • Swiss National Science Foundation
    Fellowship (1994)
  • Institute for Scientific Research in Agriculture and Industry
    Scholarship (1989)

Professional Associations/Affiliations

  • American Association for the Advancement of Science
  • American Chemical Society