Biography

Dr. DeBose-Boyd was born and raised in a small rural southeastern Oklahoma community (population 700) where he graduated from Boswell High School, Boswell, Oklahoma in 1989. Soon thereafter, he began undergraduate studies at Southeastern Oklahoma State University (SOSU) in Durant, OK, where he participated in the Minority Biomedical Research Support program.Dr. DeBose-Boyd obtained a Bachelor of Science degree in Chemistry with minors in Mathematics and Biology in 1993.

Upon completion of undergraduate studies, he was accepted into the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center, and joined the laboratory of Richard D. Cummings, PhD. In 1998, he successfully defended his thesis, entitled "Identification, characterization, and molecular cloning of alpha 1,3 fucosyltransferases in parasitic and non-parasitic helminths."

Following his defense, Dr. DeBose-Boyd joined the laboratory of Joseph L. Goldstein, M.D. and Michael S. Brown, M.D. at UT Southwestern as a fellow of the Jane Coffin Childs Memorial Fund for Medical Research. Dr. DeBose-Boyd is married to Gwendolyn and has two sons, Reginald and Ryan.

Education

Undergraduate
Southeastern Oklahoma St Univ (1993), Chemistry
Graduate School
Uni of Oklahoma-Hlth Sci Ctr (1998), Biochemistry

Research Interest

  • Cell Regulation
  • Cholesterol homeostasis
  • Endoplasmic Reticulum Associated Degradation
  • Multivalent feedback regulation of HMG CoA reductase

Publications

Featured Publications LegendFeatured Publications

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA Proc. Natl. Acad. Sci. U.S.A. 2011 Dec 108 51 20503-8
Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Jo Y, Sguigna PV, DeBose-Boyd RA J. Biol. Chem. 2011 Apr 286 17 15022-31
Regulation of cholesterol and Fatty Acid synthesis.
Ye J, Debose-Boyd RA Cold Spring Harb Perspect Biol 2011 3 7
Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets.
Hartman IZ, Liu P, Zehmer JK, Luby-Phelps K, Jo Y, Anderson RG, DeBose-Boyd RA J. Biol. Chem. 2010 Jun 285 25 19288-98
Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.
Jo Y, Debose-Boyd RA Crit. Rev. Biochem. Mol. Biol. 2010 Jun 45 3 185-98
Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.
Lee PC, DeBose-Boyd RA J. Lipid Res. 2010 Jan 51 1 192-201
Intramembrane glycine mediates multimerization of insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.
Lee, P.C., Debose-Boyd, R.A. J. Lipid Res. 2010 51 192-201
Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets.
Hartman, I.Z., Liu, P., Zehmer, J.K., Luby-Phelps, K., Jo, Y., Anderson, R.G., Debose-Boyd, R.A. J. Biol. Chem. 2010 285 19288-98
Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.
Jo, Y., Debose-Boyd, R.A. Crit. Rev. Biochem. Mol. Biol. 2010 45 185-98
Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.
Nguyen, A.D., Lee, S.H., DeBose-Boyd, R.A. J. Biol. Chem. September 2009 284 26778-88

Honors & Awards

  • Early Career Scientist Award, Howard Hughes Medical Institute
    (2009)
  • W.M. Keck Distinguished Young Scholar in Medical Research
    (2006)
  • David L. Williams Memorial Lectureship Award
    (2005)
  • Established Investigator of American Heart Association
    (2005)
  • Fellow of The Jane Coffin Childs Memorial Fund for Medical Research
    (1998)