Dr. DeBose-Boyd was born and raised in a small rural southeastern Oklahoma community (population 700) where he graduated from Boswell High School, Boswell, Oklahoma in 1989. Soon thereafter, he began undergraduate studies at Southeastern Oklahoma State University (SOSU) in Durant, OK, where he participated in the Minority Biomedical Research Support program.Dr. DeBose-Boyd obtained a Bachelor of Science degree in Chemistry with minors in Mathematics and Biology in 1993.

Upon completion of undergraduate studies, he was accepted into the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center, and joined the laboratory of Richard D. Cummings, PhD. In 1998, he successfully defended his thesis, entitled "Identification, characterization, and molecular cloning of alpha 1,3 fucosyltransferases in parasitic and non-parasitic helminths."

Following his defense, Dr. DeBose-Boyd joined the laboratory of Joseph L. Goldstein, M.D. and Michael S. Brown, M.D. at UT Southwestern as a fellow of the Jane Coffin Childs Memorial Fund for Medical Research. Dr. DeBose-Boyd is married to Gwendolyn and has two sons, Reginald and Ryan.


Southeastern Oklahoma St Univ (1993), Chemistry
Graduate School
Uni of Oklahoma-Hlth Sci Ctr (1998), Biochemistry

Research Interest

  • Cell Regulation
  • Cholesterol homeostasis
  • Endoplasmic Reticulum Associated Degradation
  • Multivalent feedback regulation of HMG CoA reductase


Featured Publications LegendFeatured Publications

Hypoxia-inducible factor-1a activates insig-2 transcription for degradation of HMG CoA reductase in the liver.
Hwang S, Nguyen AD, Jo Y, Engelking LJ, Brugarolas J, DeBose-Boyd RA J. Biol. Chem. 2017 Apr
Membrane Extraction of HMG CoA Reductase as Determined by Susceptibility of Lumenal Epitope to In Vitro Protease Digestion.
Morris LL, DeBose-Boyd RA Methods Mol. Biol. 2017 1583 193-199
Contribution of accelerated degradation to feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase and cholesterol metabolism in liver.
Hwang S, Hartman IZ, Calhoun LN, Garland K, Young GA, Mitsche MA, McDonald J, Xu F, Engelking L, DeBose-Boyd RA J. Biol. Chem. 2016 Apr
Geranylgeranyl-Regulated Transport of the Prenyltransferase UBIAD1 between Membranes of the ER and Golgi.
Schumacher MM, Jun DJ, Jo Y, Seeman J, DeBose-Boyd RA J. Lipid Res. 2016 Apr
The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase.
Schumacher MM, Elsabrouty R, Seemann J, Jo Y, DeBose-Boyd RA Elife 2015 4
Sequential actions of the AAA-ATPase VCP/p97 and the proteasome 19S regulatory particle in sterol-accelerated, ER-associated degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.
Morris LL, Hartman IZ, Jun DJ, Seemann J, DeBose-Boyd RA J. Biol. Chem. 2014 May
Sterol-Induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Membranes of Permeabilized Cells.
Elsabrouty R, Jo Y, Dinh TT, Debose-Boyd RA Mol. Biol. Cell 2013 Sep
Lipid-Regulated Degradation of HMG CoA Reductase and Insig-1 through Distinct Mechanisms in Insect Cells.
Faulkner RA, Nguyen AD, Jo Y, Debose-Boyd RA J. Lipid Res. 2013 Feb
Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.
Jo Y, Hartman IZ, Debose-Boyd RA Mol. Biol. Cell 2013 Feb 24 3 169-83
Opening up new fronts in the fight against cholesterol.
Debose-Boyd RA, Horton JD Elife 2013 2 e00663

Honors & Awards

  • Early Career Scientist Award, Howard Hughes Medical Institute
  • W.M. Keck Distinguished Young Scholar in Medical Research
  • David L. Williams Memorial Lectureship Award
  • Established Investigator of American Heart Association
  • Fellow of The Jane Coffin Childs Memorial Fund for Medical Research