Russell Debose-Boyd, Ph.D.
Professor

Dr. DeBose-Boyd was born and raised in a small rural southeastern Oklahoma community (population 700) where he graduated from Boswell High School, Boswell, Oklahoma in 1989. Soon thereafter, he began undergraduate studies at Southeastern Oklahoma State University (SOSU) in Durant, OK, where he participated in the Minority Biomedical Research Support program.Dr. DeBose-Boyd obtained a Bachelor of Science degree in Chemistry with minors in Mathematics and Biology in 1993.

Upon completion of undergraduate studies, he was accepted into the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center, and joined the laboratory of Richard D. Cummings, PhD. In 1998, he successfully defended his thesis, entitled "Identification, characterization, and molecular cloning of alpha 1,3 fucosyltransferases in parasitic and non-parasitic helminths."

Following his defense, Dr. DeBose-Boyd joined the laboratory of Joseph L. Goldstein, M.D. and Michael S. Brown, M.D. at UT Southwestern as a fellow of the Jane Coffin Childs Memorial Fund for Medical Research. Dr. DeBose-Boyd is married to Gwendolyn and has two sons, Reginald and Ryan.

Undergraduate

Southeastern Oklahoma State Un (1993), Chemistry

Graduate School

University of Oklahoma-Hlth Sc (1998), Biochemistry

• Cell Regulation
• Cholesterol homeostasis
• Endoplasmic Reticulum Associated Degradation
• Multivalent feedback regulation of HMG CoA reductase

Featured Publications

Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.

DeBose-Boyd, R.A. Cell Res. 2008 18 609-21

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

Bao-Liang Song, Navdar Sever, and Russell A. DeBose-Boyd Molecular Cell September 2005 19 829-840

Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

Bao-Liang Song, Norman B. Javitt, and Russell A. DeBose-Boyd Cell Metabolism March 2005 1 179-189

Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase

Bao-Liang Song and Russell A. DeBose-Boyd Journal of Biological Chemistry July 2004 279 28798-28806

Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain

Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A Molecular Cell 2003 11 25-33

Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi

DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J. Cell 1999 99 703-712

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond.

DeBose-Boyd RA, Ye J Trends Biochem. Sci. 2018 Feb

Significance and regulation of lipid metabolism.

DeBose-Boyd RA Semin. Cell Dev. Biol. 2017 Dec

UbiA Prenyltransferase Domain-Containing Protein-1 Modulates HMG CoA Reductase Degradation to Coordinate Synthesis of Sterol and Nonsterol Isoprenoids.

Schumacher MM, Jun DJ, Johnson BM, DeBose-Boyd RA J. Biol. Chem. 2017 Nov

Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase.

Johnson BM, DeBose-Boyd RA Semin. Cell Dev. Biol. 2017 Nov

• Early Career Scientist Award, Howard Hughes Medical Institute
  (2009)
• W.M. Keck Distinguished Young Scholar in Medical Research
  (2006)
• David L. Williams Memorial Lectureship Award
  (2005)
• Established Investigator of American Heart Association
  (2005)
• Fellow of The Jane Coffin Childs Memorial Fund for Medical Research
  (1998)