Dr. DeBose-Boyd was born and raised in a small rural southeastern Oklahoma community (population 700) where he graduated from Boswell High School, Boswell, Oklahoma in 1989. Soon thereafter, he began undergraduate studies at Southeastern Oklahoma State University (SOSU) in Durant, OK, where he participated in the Minority Biomedical Research Support program.Dr. DeBose-Boyd obtained a Bachelor of Science degree in Chemistry with minors in Mathematics and Biology in 1993.
Upon completion of undergraduate studies, he was accepted into the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center, and joined the laboratory of Richard D. Cummings, PhD. In 1998, he successfully defended his thesis, entitled "Identification, characterization, and molecular cloning of alpha 1,3 fucosyltransferases in parasitic and non-parasitic helminths."
Following his defense, Dr. DeBose-Boyd joined the laboratory of Joseph L. Goldstein, M.D. and Michael S. Brown, M.D. at UT Southwestern as a fellow of the Jane Coffin Childs Memorial Fund for Medical Research. Dr. DeBose-Boyd is married to Gwendolyn and has two sons, Reginald and Ryan.
- Southeastern Oklahoma State Un (1993), Chemistry
- Graduate School
- University of Oklahoma-Hlth Sc (1998), Biochemistry
- Cell Regulation
- Cholesterol homeostasis
- Endoplasmic Reticulum Associated Degradation
- Multivalent feedback regulation of HMG CoA reductase
- Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.
- DeBose-Boyd, R.A. Cell Res. 2008 18 609-21
- Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
- Bao-Liang Song, Navdar Sever, and Russell A. DeBose-Boyd Molecular Cell September 2005 19 829-840
- Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol
- Bao-Liang Song, Norman B. Javitt, and Russell A. DeBose-Boyd Cell Metabolism March 2005 1 179-189
- Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase
- Bao-Liang Song and Russell A. DeBose-Boyd Journal of Biological Chemistry July 2004 279 28798-28806
- Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain
- Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A Molecular Cell 2003 11 25-33
- Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi
- DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J. Cell 1999 99 703-712
- Contribution of accelerated degradation to feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase and cholesterol metabolism in liver.
- Hwang S, Hartman IZ, Calhoun LN, Garland K, Young GA, Mitsche MA, McDonald J, Xu F, Engelking L, DeBose-Boyd RA J. Biol. Chem. 2016 Apr
- Geranylgeranyl-Regulated Transport of the Prenyltransferase UBIAD1 between Membranes of the ER and Golgi.
- Schumacher MM, Jun DJ, Jo Y, Seeman J, DeBose-Boyd RA J. Lipid Res. 2016 Apr
- The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase.
- Schumacher MM, Elsabrouty R, Seemann J, Jo Y, DeBose-Boyd RA Elife 2015 4
- Sequential actions of the AAA-ATPase VCP/p97 and the proteasome 19S regulatory particle in sterol-accelerated, ER-associated degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.
- Morris LL, Hartman IZ, Jun DJ, Seemann J, DeBose-Boyd RA J. Biol. Chem. 2014 May
Honors & Awards
- Early Career Scientist Award, Howard Hughes Medical Institute
- W.M. Keck Distinguished Young Scholar in Medical Research
- David L. Williams Memorial Lectureship Award
- Established Investigator of American Heart Association
- Fellow of The Jane Coffin Childs Memorial Fund for Medical Research