Dr. DeBose-Boyd was born and raised in a small rural southeastern Oklahoma community (population 700) where he graduated from Boswell High School, Boswell, Oklahoma in 1989. Soon thereafter, he began undergraduate studies at Southeastern Oklahoma State University (SOSU) in Durant, OK, where he participated in the Minority Biomedical Research Support program.Dr. DeBose-Boyd obtained a Bachelor of Science degree in Chemistry with minors in Mathematics and Biology in 1993.

Upon completion of undergraduate studies, he was accepted into the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center, and joined the laboratory of Richard D. Cummings, PhD. In 1998, he successfully defended his thesis, entitled "Identification, characterization, and molecular cloning of alpha 1,3 fucosyltransferases in parasitic and non-parasitic helminths."

Following his defense, Dr. DeBose-Boyd joined the laboratory of Joseph L. Goldstein, M.D. and Michael S. Brown, M.D. at UT Southwestern as a fellow of the Jane Coffin Childs Memorial Fund for Medical Research. Dr. DeBose-Boyd is married to Gwendolyn and has two sons, Reginald and Ryan.


Southeastern Oklahoma St Univ (1993), Chemistry
Graduate School
Uni of Oklahoma-Hlth Sci Ctr (1998), Biochemistry

Research Interest

  • Cell Regulation
  • Cholesterol homeostasis
  • Endoplasmic Reticulum Associated Degradation
  • Multivalent feedback regulation of HMG CoA reductase


Featured Publications LegendFeatured Publications

Schnyder corneal dystrophy-associated UBIAD1 Inhibits ER-associated degradation of HMG CoA reductase in mice.
Jo Y, Hamilton JS, Hwang S, Garland K, Smith GA, Su S, Fuentes I, Neelam S, Thompson BM, McDonald JG, DeBose-Boyd RA Elife 2019 Feb 8
SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond.
DeBose-Boyd RA, Ye J Trends Biochem. Sci. 2018 Feb
Significance and regulation of lipid metabolism.
DeBose-Boyd RA Semin. Cell Dev. Biol. 2017 Dec
UbiA Prenyltransferase Domain-Containing Protein-1 Modulates HMG CoA Reductase Degradation to Coordinate Synthesis of Sterol and Nonsterol Isoprenoids.
Schumacher MM, Jun DJ, Johnson BM, DeBose-Boyd RA J. Biol. Chem. 2017 Nov
Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase.
Johnson BM, DeBose-Boyd RA Semin. Cell Dev. Biol. 2017 Nov

Honors & Awards

  • Early Career Scientist Award, Howard Hughes Medical Institute
  • W.M. Keck Distinguished Young Scholar in Medical Research
  • David L. Williams Memorial Lectureship Award
  • Established Investigator of American Heart Association
  • Fellow of The Jane Coffin Childs Memorial Fund for Medical Research