Dr. DeBose-Boyd was born and raised in a small rural southeastern Oklahoma community (population 700) where he graduated from Boswell High School, Boswell, Oklahoma in 1989. Soon thereafter, he began undergraduate studies at Southeastern Oklahoma State University (SOSU) in Durant, OK, where he participated in the Minority Biomedical Research Support program.Dr. DeBose-Boyd obtained a Bachelor of Science degree in Chemistry with minors in Mathematics and Biology in 1993.

Upon completion of undergraduate studies, he was accepted into the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center, and joined the laboratory of Richard D. Cummings, PhD. In 1998, he successfully defended his thesis, entitled "Identification, characterization, and molecular cloning of alpha 1,3 fucosyltransferases in parasitic and non-parasitic helminths."

Following his defense, Dr. DeBose-Boyd joined the laboratory of Joseph L. Goldstein, M.D. and Michael S. Brown, M.D. at UT Southwestern as a fellow of the Jane Coffin Childs Memorial Fund for Medical Research. Dr. DeBose-Boyd is married to Gwendolyn and has two sons, Reginald and Ryan.


Southeastern Oklahoma State Un (1993), Chemistry
Graduate School
University of Oklahoma-Hlth Sc (1998), Biochemistry

Research Interest

  • Cell Regulation
  • Cholesterol homeostasis
  • Endoplasmic Reticulum Associated Degradation
  • Multivalent feedback regulation of HMG CoA reductase


Featured Publications LegendFeatured Publications

Contribution of accelerated degradation to feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase and cholesterol metabolism in liver.
Hwang S, Hartman IZ, Calhoun LN, Garland K, Young GA, Mitsche MA, McDonald J, Xu F, Engelking L, DeBose-Boyd RA J. Biol. Chem. 2016 Apr
Geranylgeranyl-Regulated Transport of the Prenyltransferase UBIAD1 between Membranes of the ER and Golgi.
Schumacher MM, Jun DJ, Jo Y, Seeman J, DeBose-Boyd RA J. Lipid Res. 2016 Apr
The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase.
Schumacher MM, Elsabrouty R, Seemann J, Jo Y, DeBose-Boyd RA Elife 2015 4
Sequential actions of the AAA-ATPase VCP/p97 and the proteasome 19S regulatory particle in sterol-accelerated, ER-associated degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.
Morris LL, Hartman IZ, Jun DJ, Seemann J, DeBose-Boyd RA J. Biol. Chem. 2014 May

Honors & Awards

  • Early Career Scientist Award, Howard Hughes Medical Institute
  • W.M. Keck Distinguished Young Scholar in Medical Research
  • David L. Williams Memorial Lectureship Award
  • Established Investigator of American Heart Association
  • Fellow of The Jane Coffin Childs Memorial Fund for Medical Research