Russell DeBose-Boyd, Ph.D.

Dr. DeBose-Boyd was born and raised in a small rural southeastern Oklahoma community (population 700) where he graduated from Boswell High School, Boswell, Oklahoma in 1989. Soon thereafter, he began undergraduate studies at Southeastern Oklahoma State University (SOSU) in Durant, OK, where he participated in the Minority Biomedical Research Support program.Dr. DeBose-Boyd obtained a Bachelor of Science degree in Chemistry with minors in Mathematics and Biology in 1993.

Upon completion of undergraduate studies, he was accepted into the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center, and joined the laboratory of Richard D. Cummings, PhD. In 1998, he successfully defended his thesis, entitled "Identification, characterization, and molecular cloning of alpha 1,3 fucosyltransferases in parasitic and non-parasitic helminths."

Following his defense, Dr. DeBose-Boyd joined the laboratory of Joseph L. Goldstein, M.D. and Michael S. Brown, M.D. at UT Southwestern as a fellow of the Jane Coffin Childs Memorial Fund for Medical Research. Dr. DeBose-Boyd is married to Gwendolyn and has two sons, Reginald and Ryan.

Undergraduate

Southeastern Oklahoma St Univ (1993), Chemistry

Graduate School

Uni of Oklahoma-Hlth Sci Ctr (1998), Biochemistry

• Cell Regulation
• Cholesterol homeostasis
• Endoplasmic Reticulum Associated Degradation
• Multivalent feedback regulation of HMG CoA reductase

Featured Publications

Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.

DeBose-Boyd, R.A. Cell Res. 2008 18 609-21

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

Bao-Liang Song, Navdar Sever, and Russell A. DeBose-Boyd Molecular Cell September 2005 19 829-840

Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase

Bao-Liang Song and Russell A. DeBose-Boyd Journal of Biological Chemistry July 2004 279 28798-28806

Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain

Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A Molecular Cell 2003 11 25-33

Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi

DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J. Cell 1999 99 703-712

Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain.

Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X, Nat Commun 2022 Jul 13 1 4273

Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1.

Elsabrouty R, Jo Y, Hwang S, Jun DJ, DeBose-Boyd RA, Elife 2021 Nov 10

Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.

Long T, Liu Y, Qin Y, DeBose-Boyd RA, Li X, Sci Adv 2021 Aug 7 34

Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol.

Schumacher MM, DeBose-Boyd RA, Annu Rev Biochem 2021 Jun 90 659-679

Schnyder Corneal Dystrophy-Associated UBIAD1 is Defective in MK-4 Synthesis and Resists Autophagy-Mediated Degradation.

Jun DJ, Schumacher MM, Hwang S, Kinch LN, Grishen NV, DeBose-Boyd RA, J. Lipid Res. 2020 Mar

• Early Career Scientist Award, Howard Hughes Medical Institute
  (2009)
• W.M. Keck Distinguished Young Scholar in Medical Research
  (2006)
• David L. Williams Memorial Lectureship Award
  (2005)
• Established Investigator of American Heart Association
  (2005)
• Fellow of The Jane Coffin Childs Memorial Fund for Medical Research
  (1998)