Rueyling Lin, Ph.D. - Faculty Profile

Biography

Dr. Rueyling Lin earned her Ph.D. in Biochemistry from Baylor College of Medicine under the mentorship of Drs. C. David Allis and Stephen Elledge. She completed her postdoctoral training at the Fred Hutchinson Cancer Research Center with Dr. Jim Priess before joining UT Southwestern Medical Center's Department of Molecular Biology as an Assistant Professor in 1997, later becoming a Professor in 2012. During her tenure, she was a key member of both the Simmons Comprehensive Cancer Center and the Center for Regenerative Science and Medicine, where she made significant advances in understanding the molecular mechanisms governing the transition from oocyte to embryo and early cell fate specification.

In 2019, Dr. Lin transitioned to the Howard Hughes Medical Institute (HHMI) as a Scientific Officer, where she played an instrumental role in organizing scientific meetings for HHMI researchers, evaluating and selecting candidates for prestigious programs such as the Investigator competition and the Hanna Gray Fellowship, and overseeing special equipment competitions.

In 2023, Dr. Lin returned to UT Southwestern Medical Center as the Associate Dean for Biomedical Research Recruitment & Advancement. In this role, she leads efforts to recruit and advance world-class biomedical researchers. She supports faculty recruitment for programs such as the Cancer Prevention and Research Institute of Texas (CPRIT) and the Science and Technology Acquisition and Retention (STARS) program, coordinates recruitment initiatives for postdoctoral fellows and graduate students, and oversees the nomination process for internal and external awards, while serving as a liaison with external funding organizations.

With her extensive experience in both scientific research and leadership, Dr. Lin continues to drive innovation and excellence at UT Southwestern, fostering the next generation of biomedical scientists and enhancing the institution’s reputation as a leader in research and education.

Education

Graduate School: National Taiwan University (1987), Biochemistry
Graduate School: Baylor College of Medicine (1992), Molecular Biology
Graduate School: Baylor College of Medicine (1992), Biochemistry

Research Interest

anterior-posterior polarity
cell fate determination
oocyte maturation
oocyte-to-embryo transition

Publications

Featured Publications

Global transcriptional repression in C. elegans germline precursors by regulated sequestration of TFIID component TAF-4: Guven-Ozkan, T., Nishi, Y., Robertson, S.M., and Lin, R Cell 2008 135 149-160
A 14-3-3 protein, PAR-5, mediates nuclear export of POP-1 in Wnt/MAP kinase responsive cells in C. elegans embryos: Lo, M-C., Gay, F., Odom, R., Shi, Y., and Lin, R. Cell 2004 117 95-106
Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C. elegans.: Detwiler, M., Reuben, M.R., Li, X., Rogers, E., and Lin, R. Dev. Cell 2001 1 187-199
POP-1 and anterior-posterior fate decisions in C. elegans embryos.: Lin, R., R. Hill, and J. R. Priess Cell 1997 92 229-239
POP-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos: Lin, R., Thompson, S and Priess, J.R. Cell 1995 83 599-609
Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan.: Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Olswald NW, Zhou A, McMillan EA, Mendiratta S, Wang Z, Zhao T, Lin Z, Luo M, Huang G, Brekken RA, Posner BA, MacMillan JB, Gao J, White MA Nat Commun 2017 Dec 8 1 2270
Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway.: Dehghan E, Zhang Y, Saremi B, Yadavali S, Hakimi A, Dehghani M, Goodarzi M, Tu X, Robertson S, Lin R, Chudhuri A, Mirzaei H Nat Commun 2017 Dec 8 1 2223
Infection of Caenorhabditis elegans with Vesicular Stomatitis Virus via Microinjection.: Martin A, Rex EA, Ishidate T, Lin R, Gammon DB Bio Protoc 2017 Nov 7 22
Reciprocal signaling by Wnt and Notch specifies a muscle precursor in the C. elegans embryo.: Robertson SM, Medina J, Oldenbroek M, Lin R Development 2017 Feb 144 3 419-429
?-Catenin-related protein WRM-1 is a multifunctional regulatory subunit of the LIT-1 MAPK complex.: Yang XD, Karhadkar TR, Medina J, Robertson SM, Lin R Proc. Natl. Acad. Sci. U.S.A. 2015 Jan 112 2 E137-46