Dr. Burstein received his medical degree from Cayetano Heredia University in Lima, Peru. He completed Internal Medicine residency training at UT Southwestern and Gastroenterology fellowship training at the University of Michigan. Thereafter, he was also a research fellow at the Vaccine Research Center at the NIH. After completion of his training, he joined the Faculty at University of Michigan (2002-2008), and was later recruited to UT Southwestern, joining the Departments of Internal Medicine (Division of Digestive and Liver Diseases) and Molecular Biology.
Dr. Burstein′s research training and expertise is in the area of molecular immunology. Broadly, the work in his laboratory is focused on basic mechanisms that control inflammatory responses in human disease, particularly inflammatory bowel disease (IBD). Work from the laboratory has investigated the regulation of the NF-kB transcription factor, which led to the discovery of the COMMD protein family. Thereafter, his group has also investigated the basic functions of these factors in immune regulation, including the recent discovery of their role in endosomal protein sorting. More recently, the lab began investigating the genetic and molecular basis of altered immunity in patients with defined Mendelian disorders. These studies have led to important discoveries, including the identification of cytosolic RNA:DNA hybrids as regulators of the interferon pathway.
- Medical School
- Cayetano Heredia Peruvian University (1994)
- UT Southwestern Medical Center (1998), Internal Medicine
- University of Michigan Hospitals & Health Centers (2001), Gastroenterology
- Graduate School
- University of Groningen (2013), Molecular Genetics
- COMMD proteins: We study the regulation of endosomal protein sorting and immune function by members of this protein family.
- Genetics of inflammatory disorders: Out lab investigates the genetic basis of disorders of immune function, particularly affecting the GI tract
- Mucosal immunity and immune-tumor interactions in the GI tract
- CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling.
- Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine GN, Mao X, Zaidi IW, Hein MY, McDonald FJ, Lenzner S, Zecha A, Ropers HH, Kuss AW, McGaughran J, Gecz J, Burstein E J. Clin. Invest. 2013 Apr
- Regulation of NF-?B activity by competition between RelA acetylation and ubiquitination.
- Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E Oncogene 2011 Jun
- COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.
- van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E J. Clin. Invest. 2010 Jun 120 6 2119-30
- GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA.
- Mao X, Gluck N, Li D, Maine GN, Li H, Zaidi IW, Repaka A, Mayo MW, Burstein E Genes Dev. 2009 Apr 23 7 849-61
- XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders.
- Mufti AR, Burstein E, Csomos RA, Graf PC, Wilkinson JC, Dick RD, Challa M, Son JK, Bratton SB, Su GL, Brewer GJ, Jakob U, Duckett CS Mol. Cell 2006 Mar 21 6 775-85
- A novel role for XIAP in copper homeostasis through regulation of MURR1.
- Burstein E, Ganesh L, Dick RD, van De Sluis B, Wilkinson JC, Klomp LW, Wijmenga C, Brewer GJ, Nabel GJ, Duckett CS EMBO J. 2004 Jan 23 1 244-54
- The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes.
- Ganesh L, Burstein E, Guha-Niyogi A, Louder MK, Mascola JR, Klomp LW, Wijmenga C, Duckett CS, Nabel GJ Nature 2003 Dec 426 6968 853-7
Honors & Awards
- Berta M. and Cecil O. Patterson Chair in Gastroenterology
- Physician of the Year
North Texas Chapter, Crohn's and Colitis Foundation (2017)
The American Society for Clinical Investigation (ASCI) (2012)
- Helmsley Scholar
Crohn’s and Colitis Foundation of America (2010)
- AGA Research Scholar Award
Foundation for Digestive Health and Nutrition (2003)
- John S. Miller Award
Outstanding Performance as a House Officer, UT Southwestern Medical School (1998)
Medical School of Cayetano Heredia University (1994)
- American Society for Cell biology (ASCB) (2014)
- American Society for Clinical Investigation (ASCI) (2012)
- American Gastroenterological Association (AGA) (1999)