Zhijian Chen, Ph.D. Professor Endowed Title George L. MacGregor Distinguished Chair in Biomedical Science School Medical School Department Molecular Biology | Center for Genetics of Host Defense Graduate Programs Genetics, Development and Disease, Immunology Education Undergraduate Fujian Normal University (1985), Biology Graduate School SUNY at Buffalo (1991), Biochemistry Research Interest Innate Immunity MAVS: mitochondrial antiviral signaling protein NF-kappaB Signaling RIG-I Signaling Ubiquitin-Proteasome Pathway Publications The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion Uslu U, Sun L, Castelli S, Finck AV, Assenmacher CA, Young RM, Chen ZJ, June CH Nature communications 2024 Dec 15 cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation Zhao R, Zhang J, Ma J, Qu Y, Yang Z, Yin Z, Li F, Dong Z, Sun Q, Zhu S, Chen ZJ, Gao D Science Immunology 2024 Aug 9 cGAS goes viral: A conserved immune defense system from bacteria to humans Jenson JM, Chen ZJ Molecular cell 2024 Jan 84 120-130 Orthogonal Hydroxyl Functionalization of cGAMP Confers Metabolic Stability and Enables Antibody Conjugation Chen C, Lu Y, You L, Li L, Kilgore JA, Liu S, Wang X, Dai Y, Wei Q, Shi H, Han L, Sun L, Chen ZJ, Zhang X, Williams NS ACS Central Science 2023 Dec 9 2298-2305 Vaccinia E5 is a major inhibitor of the DNA sensor cGAS Yang N, Wang Y, Dai P, Li T, Zierhut C, Tan A, Zhang T, Xiang JZ, Ordureau A, Funabiki H, Chen Z, Deng L Nature communications 2023 Dec 14 Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence Jenson JM, Li T, Du F, Ea CK, Chen ZJ Nature 2023 Apr 616 326-331 Tumor-targeted delivery of a STING agonist improves cancer immunotherapy Wu YT, Fang Y, Wei Q, Shi H, Tan H, Deng Y, Zeng Z, Qiu J, Chen C, Sun L, Chen ZJ Proceedings of the National Academy of Sciences of the United States of America 2022 Dec 119 An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif Fang Y, Sun P, Xie X, Du M, Du F, Ye J, Kalveram BK, Plante JA, Plante KS, Li B, Bai XC, Shi PY, Chen ZJ Science Immunology 2022 Oct 7 Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB Du M, Ea CK, Fang Y, Chen ZJ Molecular cell 2022 Jul 82 2415-2426.e5 Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer Lee KM, Lin CC, Servetto A, Bae J, Kandagatla V, Ye D, Kim GM, Sudhan DR, Mendiratta S, Ericsson PI, Balko JM, Lee J, Barnes S, Malladi V, Tabrizi S, Reddy SM, Yum S, Chang CW, Hutchinson KE, Yost SE, Yuan Y, Chen ZJ, Fu Y, Hanker AB, Arteaga CL Cancer Immunology Research 2022 Jul 10 829-843 Results 1-10 of 205 1 2 3 4 5 Next Last Honors & Awards Albert Lasker Basic Medical Research AwardThe Albert Lasker Basic Medical Research Award for Dr. Chen's discovery of the cGAS enzyme. (2024) Louisa Gross Horwitz Prize (2023) Member, National Academy of Medicine, USA (2022) William B. Coley Award for Distinguished Research in Basic and Tumor Immunology (2020) Breakthrough Prize in Life SciencesFor his discovery of the cGAS enzyme that launches the body's immune defense against infections and cancers. That enzyme patrols the cell's interior and triggers the immune system in response to DNA. (2019) Lurie Prize in Biomedical SciencesFor his discovery of the cGAS enzyme, a sensor of innate immunity. The enzyme patrols the cells interior and sounds the alarm to trigger the immune system in response to DNA. (2018) NAS Award in Molecular BiologyFor his creative use of elegant biochemistry both in elucidating an unsuspected role for polyubiquitin in a kinase-signaling cascade important for cancer and immunity and in discovering a novel link between innate immunity and a mitochondrial membrane protein that forms prion-like polymers to trigger antiviral responses. (2012) Edith and Peter O’Donnell Award in Science by The Academy of Medicine, Engineering and Science of Texas (2007) Welch Foundation Norman Hackerman Award in Chemical Research (2005) Burroughs Wellcome Fund Investigator in Pathogenesis of Infectious Diseases (2002) Leukemia and Lymphoma Society Scholar (2002) Searle Scholar (1998)
