Kenneth Westover, M.D., Ph.D.

Other Post Graduate Training

Stanford University (2007)

Medical School

Stanford University School of Medicine (2007)

Graduate School

Stanford University (2007), Medical Scientist Training Program

Internship

Harvard/Brigham and Women's Hospital (2008), Internal Medicine

Residency

Harvard/Brigham and Women's Hospital/Massachusetts General Hospital (2012), Radiation Oncology

• Cancer imaging
• Cancer therapeutics
• Kinase biology and inhibitor development
• RAS biology and inhibitor development
• Stereotactic radiation therapy
• Structural biology
• Use of technology to improve cancer care

Featured Publications

Tissue-specific oncogenic activity of K-RasA146T.

Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM, Cancer Discov 2019 Apr

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS.

Ambrogio C, Köhler J, Zhou ZW, Wang H, Paranal R, Li J, Capelletti M, Caffarra C, Li S, Lv Q, Gondi S, Hunter JC, Lu J, Chiarle R, Santamaría D, Westover KD, Jänne PA Cell 2018 Jan

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.

Zeng M, Lu J, Li L, Feru F, Quan C, Gero TW, Ficarro SB, Xiong Y, Ambrogio C, Paranal RM, Catalano M, Shao J, Wong KK, Marto JA, Fischer ES, Jänne PA, Scott DA, Westover KD, Gray NS Cell Chem Biol 2017 Aug 24 8 1005-1016.e3

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.

Hunter JC, Manandhar A, Carrasco MA, Gurbani D, Gondi S, Westover KD Mol. Cancer Res. 2015 Jun

Loss of wild type KRAS in KRAS^MUT lung adenocarcinoma is associated with cancer mortality and confers sensitivity to FASN inhibitors.

Liu Y, Gao GF, Minna JD, Williams NS, Westover KD, Lung Cancer 2021 Jan 153 73-80

Development of a real-time indoor location system using bluetooth low energy technology and deep learning to facilitate clinical applications.

Tang G, Yan Y, Shen C, Jia X, Zinn M, Trivedi Z, Yingling A, Westover K, Jiang S, Med Phys 2020 Aug 47 8 3277-3285

Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing.

Liu Y, Ferguson FM, Li L, Kuljanin M, Mills CE, Subramanian K, Harshbarger W, Gondi S, Wang J, Sorger PK, Mancias JD, Gray NS, Westover KD, Cell Chem Biol 2020 Aug

Small molecule inhibition of non-canonical (TAK1-mediated) BMP signaling results in reduced chondrogenic ossification and heterotopic ossification in a rat model of blast-associated combat-related lower limb trauma.

Strong AL, Spreadborough PJ, Pagani CA, Haskins RM, Dey D, Grimm PD, Kaneko K, Marini S, Huber AK, Hwang C, Westover K, Mishina Y, Bradley MJ, Levi B, Davis TA, Bone 2020 Jul 139 115517

Synthesis and structure activity relationships of DCLK1 kinase inhibitors based on a 5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one scaffold.

Ferguson FM, Liu Y, Harshbarger W, Huang L, Wang J, Deng X, Capuzzi SJ, Muratov EN, Tropsha A, Muthuswamy S, Westover KD, Gray NS, J. Med. Chem. 2020 Jun

KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer.

Zhou ZW, Ambrogio C, Bera AK, Li Q, Li XX, Li L, Son J, Gondi S, Li J, Campbell E, Jin H, Okoro JJ, Xu CX, Janne PA, Westover KD, Cancer Res. 2020 Jun

 Featured Books

Liver. In Human Radiation Injury

Shrieve D, Loeffler J, et al (2010). Philadelphia, PA, Lippincott Williams & Wilkins

Radiation. In Pocket Neurology

Westover MB, Choi E, Awad K (2010). Philadelphia, PA, Lippincott Williams & Wilkins

• V Scholar
  (2014-2016)
• CPRIT Scholar
  (2012-2016)

• American Association for Cancer Research
• American College of Radiology
• American Society for Therapeutic Radiation and Oncology