
Kenneth Westover, M.D., Ph.D.
Director of Clinical Innovation
Associate Professor
School Medical School
Department Radiation Oncology | Biochemistry
Graduate Programs Biological Chemistry, Cancer Biology
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Education
- Medical School
- Stanford University School of Medicine (2007)
- Other Post Graduate Training
- Stanford University (2007)
- Graduate School
- Stanford University (2007), Medical Scientist Training Program
- Internship
- Harvard/Brigham and Women's Hospital (2008), Internal Medicine
- Residency
- Harvard/Brigham and Women's Hospital/Massachusetts General Hospital (2012), Radiation Oncology
Research Interest
- Cancer imaging
- Cancer therapeutics
- Kinase biology and inhibitor development
- RAS biology and inhibitor development
- Stereotactic radiation therapy
- Structural biology
- Use of technology to improve cancer care
Publications
Featured Publications
- Tissue-specific oncogenic activity of K-RasA146T.
- Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM, Cancer Discov 2019 Apr
- KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS.
- Ambrogio C, Köhler J, Zhou ZW, Wang H, Paranal R, Li J, Capelletti M, Caffarra C, Li S, Lv Q, Gondi S, Hunter JC, Lu J, Chiarle R, Santamaría D, Westover KD, Jänne PA Cell 2018 Jan
- Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.
- Zeng M, Lu J, Li L, Feru F, Quan C, Gero TW, Ficarro SB, Xiong Y, Ambrogio C, Paranal RM, Catalano M, Shao J, Wong KK, Marto JA, Fischer ES, Jänne PA, Scott DA, Westover KD, Gray NS Cell Chem Biol 2017 Aug 24 8 1005-1016.e3
- Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
- Hunter JC, Manandhar A, Carrasco MA, Gurbani D, Gondi S, Westover KD Mol. Cancer Res. 2015 Jun
- Loss of wild type KRAS in KRASMUT lung adenocarcinoma is associated with cancer mortality and confers sensitivity to FASN inhibitors.
- Liu Y, Gao GF, Minna JD, Williams NS, Westover KD, Lung Cancer 2021 Jan 153 73-80
- Development of a real-time indoor location system using bluetooth low energy technology and deep learning to facilitate clinical applications.
- Tang G, Yan Y, Shen C, Jia X, Zinn M, Trivedi Z, Yingling A, Westover K, Jiang S, Med Phys 2020 Aug 47 8 3277-3285
- Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing.
- Liu Y, Ferguson FM, Li L, Kuljanin M, Mills CE, Subramanian K, Harshbarger W, Gondi S, Wang J, Sorger PK, Mancias JD, Gray NS, Westover KD, Cell Chem Biol 2020 Aug
- Small molecule inhibition of non-canonical (TAK1-mediated) BMP signaling results in reduced chondrogenic ossification and heterotopic ossification in a rat model of blast-associated combat-related lower limb trauma.
- Strong AL, Spreadborough PJ, Pagani CA, Haskins RM, Dey D, Grimm PD, Kaneko K, Marini S, Huber AK, Hwang C, Westover K, Mishina Y, Bradley MJ, Levi B, Davis TA, Bone 2020 Jul 139 115517
- Synthesis and structure activity relationships of DCLK1 kinase inhibitors based on a 5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one scaffold.
- Ferguson FM, Liu Y, Harshbarger W, Huang L, Wang J, Deng X, Capuzzi SJ, Muratov EN, Tropsha A, Muthuswamy S, Westover KD, Gray NS, J. Med. Chem. 2020 Jun
- KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer.
- Zhou ZW, Ambrogio C, Bera AK, Li Q, Li XX, Li L, Son J, Gondi S, Li J, Campbell E, Jin H, Okoro JJ, Xu CX, Janne PA, Westover KD, Cancer Res. 2020 Jun
Books
Featured Books
Liver. In Human Radiation Injury
Shrieve D, Loeffler J, et al (2010). Philadelphia, PA, Lippincott Williams & Wilkins
Radiation. In Pocket Neurology
Westover MB, Choi E, Awad K (2010). Philadelphia, PA, Lippincott Williams & Wilkins
Honors & Awards
- V Scholar
(2014-2016) - CPRIT Scholar
(2012-2016)
Professional Associations/Affiliations
- American Association for Cancer Research
- American College of Radiology
- American Society for Therapeutic Radiation and Oncology