Rose Langsjoen, Ph.D. - Faculty Profile

Biography

Rose Langsjoen, PhD is an Instructor in the Department of Internal Medicine, Division of Infectious Diseases and Geographic medicine at UT Southwestern Medical Center. Dr. Langsjoen is primarily interested in arboviruses, viral recombination, and viral population dynamics as they relate to transmission and pathogenesis.

Dr. Langsjoen earned her bachelor's degree from Gustavus Adolphus College and her PhD in Human Pathophysiology and Translational Medicine from the University of Texas Medical Branch (UTMB), where she studied alphavirus vaccine development, antiviral therapeutics, and animal models of disease. During her postdoctoral training at UTMB, she investigated viral recombination in RNA viruses and developed sequencing-based approaches to characterize viral population diversity. She subsequently expanded her expertise in viral evolution, population dynamics, and bioinformatics as a Research Scientist at Emory University.

At UT Southwestern, Dr. Langsjoen leads a research program focused on understanding how RNA viruses generate, maintain, and transmit genetic diversity. Her laboratory studies the mechanisms and consequences of viral recombination in arboviruses and develops innovative experimental and sequencing-based approaches to investigate viral population structure at high resolution. By integrating molecular virology, genomics, and quantitative analysis, her work aims to uncover fundamental principles governing viral evolution, host adaptation, and pathogenesis.

Education

Graduate School: (2016)

Research Interest

Arboviruses
Defective RNAs
Diagnostics
Methods development
RNA recombination
RNA viruses
Sequencing

Publications

Featured Publications

Evidence for Powassan virus deletions and defective RNA in field-collected ticks.: Courtney SJ, Langsjoen RM, Trammell CE, Robich RM, Goethert HK, McMinn RJ, Telford SR, Ebel GD, Piantadosi A, J Virol 2026 Jan e0135625
Eastern Equine Encephalitis Virus Diversity in Massachusetts Patients, 1938-2020.: Langsjoen RM, Key A, Shariatzadeh N, Jackson CR, Mahmood F, Arkun K, Alexandrescu S, Solomon IH, Piantadosi A, Am J Trop Med Hyg 2023 Aug 109 2 387-396
Chikungunya Virus Infects the Heart and Induces Heart-Specific Transcriptional Changes in an Immunodeficient Mouse Model of Infection.: Langsjoen RM, Zhou Y, Holcomb RJ, Routh AL, Am J Trop Med Hyg 2021 Nov 106 1 99-104
Differential Alphavirus Defective RNA Diversity between Intracellular and Extracellular Compartments Is Driven by Subgenomic Recombination Events.: Langsjoen RM, Muruato AE, Kunkel SR, Jaworski E, Routh A, mBio 2020 Aug 11 4
Host oxidative folding pathways offer novel anti-chikungunya virus drug targets with broad spectrum potential.: Langsjoen RM, Auguste AJ, Rossi SL, Roundy CM, Penate HN, Kastis M, Schnizlein MK, Le KC, Haller SL, Chen R, Watowich SJ, Weaver SC, Antiviral Res 2017 Jul 143 246-251
Viral and host factors associated with SARS-CoV-2 disease severity in Georgia, USA.: Carmola LR, Roebling AD, Khosravi D, Langsjoen RM, Bombin A, Bixler B, Reid A, Chen C, Wang E, Lu Y, Zheng Z, Zhang R, Nguyen PV, Arthur RA, Fitts E, Gulick DA, Higginbotham D, Taz A, Ahmed A, Crumpler JH, Kraft C, Lam WA, Babiker A, Waggoner JJ, Openo KP, Johnson LM, Westbrook A, Piantadosi A, PLoS One 2025 20 4 e0317972
Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV.: Khosravi D, Soloff H, Langsjoen RM, Bombin A, Kelley CF, Ray SM, Gunthel CJ, Zanoni BC, Nguyen PV, Waggoner JJ, Wang YF, Cantos VD, Piantadosi A, Open Forum Infect Dis 2023 Feb 10 2 ofad054
Phylodynamics of deer tick virus in North America.: McMinn RJ, Langsjoen RM, Bombin A, Robich RM, Ojeda E, Normandin E, Goethert HK, Lubelczyk CB, Schneider E, Cosenza D, Meagher M, Prusinski MA, Sabeti PC, Smith RP, Telford SR, Piantadosi A, Ebel GD, Virus Evol 2023 9 1 vead008
SARS-CoV-2 Evolution and Immune Escape in Immunocompromised Patients.: Scherer EM, Babiker A, Adelman MW, Allman B, Key A, Kleinhenz JM, Langsjoen RM, Nguyen PV, Onyechi I, Sherman JD, Simon TW, Soloff H, Tarabay J, Varkey J, Webster AS, Weiskopf D, Weissman DB, Xu Y, Waggoner JJ, Koelle K, Rouphael N, Pouch SM, Piantadosi A, N Engl J Med 2022 Jun 386 25 2436-2438
Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge.: Muruato A, Vu MN, Johnson BA, Davis-Gardner ME, Vanderheiden A, Lokugamage K, Schindewolf C, Crocquet-Valdes PA, Langsjoen RM, Plante JA, Plante KS, Weaver SC, Debbink K, Routh AL, Walker D, Suthar MS, Shi PY, Xie X, Menachery VD, PLoS Biol 2021 Nov 19 11 e3001284