Wen-Yuan Hsieh, M.D. Titles and Appointments Associate Professor & Division Chief Schools Medical School Departments Pediatrics | Eugene McDermott Center for Human Growth and Development | Immunology | Internal Medicine Biography Wen-Yuan "Elena" Hsieh, M.D., is an Associate Professor in the Department of Pediatrics and Internal Medicine at UT Southwestern Medical Center. Dr. Hsieh holds a bachelor’s degree from the University of California Los Angeles (UCLA). She received her medical degree from the University of California San Francisco and completed pediatrics residency training at UCLA Medical Center. She then obtained advanced training through a fellowship in allergy and immunology at Stanford Hospital and Clinics in Stanford, California. Certified by the American Board of Internal Medicine, Dr. Hsieh joined the UT Southwestern faculty in 2026. She previously served as an Associate Professor of Pediatrics and Allergy/Immunology at the University of Colorado School of Medicine in Aurora, Colorado, where she directed the Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies and served as Director of the Federation of Clinical Immunology Societies Center of Excellence. As a physician-scientist whose career bridges rare and common immune disorders, she has led pioneering efforts to integrate cutting-edge immune-profiling technologies and genetic variant interpretation into clinical practice, particularly for patients with rare immune dysregulation syndromes and autoimmune diseases. Her research program, continuously supported by the NIH, Lupus Research Alliance, Arthritis Foundation, and Boettcher Foundation, has advanced the mechanistic understanding of immune dysregulation in inborn errors of immunity, lupus, and other autoimmune diseases, bridging discovery science and patient care to propel precision medicine. Her contributions have been recognized with numerous honors, including the Boettcher Foundation Webb-Waring Award, the Women in STEM Leadership Award, and election to the Henry Kunkel Society. She is also a Fellow of the Clinical Immunology Society. She is an active member of several professional organizations, including the Clinical Immunology Society, the American Academy of Allergy, Asthma & Immunology, the European Society for Immunodeficiencies, the American Association of Immunologists, and the American College of Rheumatology. Research Interest Autoimmune and Chronic Inflammatory Disorders Mechanisms of Innate Immune Dysregulation Translational and Precision-Medicine Approaches to Immune-Mediated Disease Publications Featured Publications Key considerations for advancing chimeric antigen receptor (CAR) T-cell therapy for systemic lupus erythematosus (SLE): a multi-partner/disciplinary working group perspective. Hsieh EWY, Chung JB, Amin A, Askanase AD, Bartok B, Brunetta P, Carrasco-Alfonso MJ, Coney C, Cooper JC, Dall'Era M, Delev N, Eldred A, Furie RA, Garces S, Groover K, Harrington M, Hogan JJ, Imperato GH, Jackson M, Jackson SW, Jongco AM, Karis E, Koegel A, König MF, Koretzky G, Kumar V, Morand E, Payne AS, Popat V, Rizvi N, Rohan P, Sadelain M, Schett G, Singh AP, van Vollenhoven RF, Zack D, RMD Open 2025 Oct 11 4 cytoKernel: robust kernel embeddings for assessing differential expression of single-cell data. Ghosh T, Baxter RM, Seal S, Lui VG, Rudra P, Vu T, Hsieh EWY, Ghosh D, Bioinformatics 2025 Jul 41 7 A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency. Cabrera-Martinez B, Garcia-Perez JE, Baxter RM, Lui VG, Ghosh T, Eken A, Kostka-Newman Z, Garcia JRM, Rahkola J, Gessner RL, Dutmer CM, Klarquist J, Pietras EM, Ghosh D, Johnson SA, Kedl RM, Hsieh EWY, Cell Rep 2025 Jun 44 7 115902 Precision Medicine in Pediatric Autoimmunity: Leniolisib Treatment of Childhood-Onset Lupus Nephritis Due to Activated PI3K-Delta Syndrome (APDS). Lim JP, Ahmadian M, Du H, Rickert C, Ghosh T, Xing F, Minic A, Johnson SA, Weinman JP, Willard N, Lin C, Cooper JC, Hanna M, Knight V, Ghosh D, Jordan KR, Hsieh EW, Arthritis Rheumatol 2025 May Childhood-onset lupus nephritis is characterized by complex interactions between kidney stroma and infiltrating immune cells. Danaher P, Hasle N, Nguyen ED, Roberts JE, Rosenwasser N, Rickert C, Hsieh EWY, Hayward K, Okamura DM, Alpers CE, Reed RC, Baxter SK, Jackson SW, Sci Transl Med 2024 Nov 16 775 eadl1666 Results 1-5 of 5 1 Honors & Awards NIH K23 Mentored Patient-Oriented Research Career Development Award, NIH (2017) Boettcher Foundation Webb-Waring Biomedical Research Award, Boettcher Foundation (2016) Professional Associations/Affiliations American Academy of Asthma, Allergy and Immunology (AAAAI) American Association of Immunologists (AAI) American College Rheumatology (ACR) Childhood Arthritis and Rheumatology Research Alliance (CARRA) Clinical Immunology Society (CIS) European Society for Immunodeficiencies (ESID)
