Wen-Yuan Hsieh, M.D. Titles and Appointments Associate Professor & Division Chief Schools Medical School Departments Pediatrics | Eugene McDermott Center for Human Growth and Development | Immunology | Internal Medicine Biography Wen-Yuan “Elena” Hsieh, M.D., is an Associate Professor in the Department of Pediatrics and Internal Medicine, and in the Eugene McDermott Center for Human Growth and Development at UT Southwestern Medical Center where she also serves as Chief of the Division of Pediatric Allergy and Immunology. Certified by The American Board of Pediatrics and the American Board of Allergy and Immunology, Dr. Hsieh joined the UT Southwestern faculty in 2026. Dr. Hsieh is an active physician-scientist specializing in inborn errors of immunity, with a focus on defining the molecular and cellular mechanisms that drive immune dysregulation. Her research leverages high-dimensional single-cell and multi-omic approaches to identify pathogenic pathways and translate these discoveries into precision, pathway-targeted therapies. Her work has led to the identification and mechanistic characterization of novel immune dysregulation disorders, including defining the role of IL2RB, LCK, and other T-cell receptor signaling defects in human disease, providing key insights into immune homeostasis and autoimmunity and informing the development of targeted immunotherapies. By bridging rare genetic disorders to more common conditions, her research has advanced understanding of diseases such as lupus and inflammatory bowel disease and informed the development of targeted therapeutic strategies. Her program is continuously supported by the National Institutes of Health and major foundations, including the Lupus Research Alliance and Arthritis Foundation. Prior to joining UT Southwestern, Dr. Hsieh was an Associate Professor at the University of Colorado Anschutz School of Medicine, where she directed the Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies and led a Federation of Clinical Immunology Societies (FOCiS) Center of Excellence. Research Interest Autoimmune and Chronic Inflammatory Disorders Mechanisms of Innate Immune Dysregulation Translational and Precision-Medicine Approaches to Immune-Mediated Disease Publications Featured Publications Key considerations for advancing chimeric antigen receptor (CAR) T-cell therapy for systemic lupus erythematosus (SLE): a multi-partner/disciplinary working group perspective. Hsieh EWY, Chung JB, Amin A, Askanase AD, Bartok B, Brunetta P, Carrasco-Alfonso MJ, Coney C, Cooper JC, Dall'Era M, Delev N, Eldred A, Furie RA, Garces S, Groover K, Harrington M, Hogan JJ, Imperato GH, Jackson M, Jackson SW, Jongco AM, Karis E, Koegel A, König MF, Koretzky G, Kumar V, Morand E, Payne AS, Popat V, Rizvi N, Rohan P, Sadelain M, Schett G, Singh AP, van Vollenhoven RF, Zack D, RMD Open 2025 Oct 11 4 cytoKernel: robust kernel embeddings for assessing differential expression of single-cell data. Ghosh T, Baxter RM, Seal S, Lui VG, Rudra P, Vu T, Hsieh EWY, Ghosh D, Bioinformatics 2025 Jul 41 7 A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency. Cabrera-Martinez B, Garcia-Perez JE, Baxter RM, Lui VG, Ghosh T, Eken A, Kostka-Newman Z, Garcia JRM, Rahkola J, Gessner RL, Dutmer CM, Klarquist J, Pietras EM, Ghosh D, Johnson SA, Kedl RM, Hsieh EWY, Cell Rep 2025 Jun 44 7 115902 Precision Medicine in Pediatric Autoimmunity: Leniolisib Treatment of Childhood-Onset Lupus Nephritis Due to Activated PI3K-Delta Syndrome (APDS). Lim JP, Ahmadian M, Du H, Rickert C, Ghosh T, Xing F, Minic A, Johnson SA, Weinman JP, Willard N, Lin C, Cooper JC, Hanna M, Knight V, Ghosh D, Jordan KR, Hsieh EW, Arthritis Rheumatol 2025 May Childhood-onset lupus nephritis is characterized by complex interactions between kidney stroma and infiltrating immune cells. Danaher P, Hasle N, Nguyen ED, Roberts JE, Rosenwasser N, Rickert C, Hsieh EWY, Hayward K, Okamura DM, Alpers CE, Reed RC, Baxter SK, Jackson SW, Sci Transl Med 2024 Nov 16 775 eadl1666 Results 1-5 of 5 1 Honors & Awards NIH K23 Mentored Patient-Oriented Research Career Development Award, NIH (2017) Boettcher Foundation Webb-Waring Biomedical Research Award, Boettcher Foundation (2016) Professional Associations/Affiliations American Academy of Asthma, Allergy and Immunology (AAAAI) American Association of Immunologists (AAI) American College Rheumatology (ACR) Childhood Arthritis and Rheumatology Research Alliance (CARRA) Clinical Immunology Society (CIS) European Society for Immunodeficiencies (ESID)
