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Mason Sweat, Ph.D.

Mason Sweat, Ph.D.

Titles and Appointments

Assistant Professor

School
Medical School
Department
Internal Medicine
  • Biography

    Download Curriculum Vitae

    Dr. Sweat is an Assistant Professor in the Division of Cardiology, Department of Internal Medicine.  Dr. Mason Sweat, originally from Iowa City, Iowa, earned his doctorate at the University of Iowa Carver College of Medicine. He completed postdoctoral training in the lab of William Pu, M.D., at Boston Children’s Hospital and Harvard Medical School, where he honed his expertise in cardiac biology.

  • Education
    Graduate School
    University of Iowa (2020)
  • Research Interest
    • Cardiac Arrhythmia, Cardiomyocyte identity mechanisms, Atrial Fibrillation
  • Publications

    Star Featured Publications

    CHD4 Interacts With TBX5 to Maintain the Gene Regulatory Network of Postnatal Atrial Cardiomyocytes.
    Sweat ME, Shi W, Keating EM, Ponek A, Li J, Ma Q, Park C, Trembley MA, Wang Y, Bezzerides VJ, Conlon FL, Pu WT, bioRxiv 2024 Dec
    Genetic and Molecular Underpinnings of Atrial Fibrillation.
    Sweat ME, Pu WT, NPJ Cardiovasc Health 2024 1
    Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.
    Sweat ME, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Arulsamy K, Lu F, Keating EM, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Hill LD, Kyoung Song M, Trembley MA, Wang P, Gianeselli M, Prondzynski M, Bortolin RH, Bezzerides VJ, Chen K, Seidman JG, Seidman CE, Moskowitz IP, Pu WT, Nat Cardiovasc Res 2023 Oct 2 10 881-898
    Tbx5 maintains atrial identity by regulating an atrial enhancer network.
    Sweat ME, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Song MK, Trembley MA, Wang P, Lu F, Gianeselli M, Prondzynski M, Bortolin RH, Seidman JG, Seidman CE, Moskowitz IP, Pu WT, bioRxiv 2023 Apr
    In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity.
    Cao Y, Zhang X, Akerberg BN, Yuan H, Sakamoto T, Xiao F, VanDusen NJ, Zhou P, Sweat ME, Wang Y, Prondzynski M, Chen J, Zhang Y, Wang P, Kelly DP, Pu WT, Circulation 2023 Mar 147 11 881-896
    HMGN2 represses gene transcription via interaction with transcription factors Lef-1 and Pitx2 during amelogenesis.
    Eliason S, Su D, Pinho F, Sun Z, Zhang Z, Li X, Sweat M, Venugopalan SR, He B, Bustin M, Amendt BA, J Biol Chem 2022 Sep 298 9 102295
    CMYA5 establishes cardiac dyad architecture and positioning.
    Lu F, Ma Q, Xie W, Liou CL, Zhang D, Sweat ME, Jardin BD, Naya FJ, Guo Y, Cheng H, Pu WT, Nat Commun 2022 Apr 13 1 2185
    miR-17 acts as a tumor suppressor by negatively regulating the miR-17-92 cluster.
    Sweat Y, Ries RJ, Sweat M, Su D, Shao F, Eliason S, Amendt BA, Mol Ther Nucleic Acids 2021 Dec 26 1148-1158
    Rat Calvarial Bone Regeneration by 3D-Printed β-Tricalcium Phosphate Incorporating MicroRNA-200c.
    Remy MT, Akkouch A, He L, Eliason S, Sweat ME, Krongbaramee T, Fei F, Qian F, Amendt BA, Song X, Hong L, ACS Biomater Sci Eng 2021 Sep 7 9 4521-4534
    The miR-200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche.
    Sweat M, Sweat Y, Yu W, Su D, Leonard RJ, Eliason SL, Amendt BA, Stem Cells 2021 Jun 39 6 761-775