Uriel Sandkovsky, M.D. Titles and Appointments Professor School Medical School Department Internal Medicine You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Uriel Sandkovsky, M.D., M.S., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Infectious Diseases and Geographic Medicine. Dr. Sandkovsky received his medical education at Maimonides University in Buenos Aires, Argentina. He completed internal medicine residency training at Mount Sinai Morningside (formerly St. Luke's-Roosevelt Hospital Center) in New York, followed by a fellowship in infectious diseases at Montefiore Medical Center and Albert Einstein College of Medicine in Bronx, New York. Prior to joining the UT Southwestern faculty in 2025, Dr. Sandkovsky served on the faculty at Texas A&M University and at the University of Nebraska Medical Center, where he was Medical Director for the Comparitive Medicine and Select Agent Program and an attending physician on the solid organ transplant infectious disease service. Dr. Sandkovsky's research spans several interconnected domains within infectious diseases and transplant medicine. His work in solid organ transplantation includes studies on cytomegalovirus (CMV) resistance and the impact of hypogammaglobulinemia on post-transplant infections. In the area of HIV/AIDS clinical care and treatment, he has focused on coordinated services and early intervention in the Ryan D. White Part D and Title III grants programs. He also has explored innovative educational strategies for HIV care through a flipped classroom model and investigated antiretroviral pharmacokinetics, specifically Raltegravir concentrations. His research in neurocognitive complications of HIV (NeuroAIDS) includes participation in studies using magnetoencephalography (MEG) to identify neurophysiological markers of HIV-associated neurocognitive disorders and aging. Additionally, he has addressed sexually transmitted infections in HIV-positive populations, particularly the prevalence of gonorrhea and chlamydia in men who have sex with men. His basic science research has explored the antimicrobial mechanisms of nitric oxide against gram-negative bacteria. These projects collectively reflect a comprehensive approach to infectious disease research, integrating clinical, translational, and public health perspectives. Dr. Sandkovsky has also participated in a range of clinical trials, reflecting his expertise in HIV treatment, COVID-19 therapeutics, and infectious disease prevention. In the area of HIV research, he was involved in several pivotal Phase III trials evaluating antiretroviral therapies that contributed to the development of modern HIV treatment standards. In response to the COVID-19 pandemic, Dr. Sandkovsky played a key role in multiple studies, including observational work on SARS-CoV-2 seroprevalence in healthcare workers and NIH-sponsored interventional studies evaluating investigational COVID-19 therapeutics. His work also extends to vaccine and antiviral development beyond COVID-19. He participated in a Phase 3 trial of a vaccine for RSV in older adults, and in the investigation of a novel antibody-based pre-exposure prophylaxis. Most recently, he served as principal investigator for a randomized controlled trial evaluating a treatment of human mpox. Dr. Sandkovsky is an active member of several professional organizations, including the Infectious Diseases Society of America and the American College of Physicians, in both of which he is a Fellow. Publications Featured Publications Long-term outcomes of passive immunotherapy for COVID-19: a pooled analysis of a large multinational platform randomized clinical trial. Mourad A, Grandits GA, Siegel LK, Engen N, Barkauskas C, Eriobu N, Jain MK, Jensen TO, Ginde A, Higgs E, Knox DB, Kitonsa J, Kim K, Malin JJ, Rapti V, Price DA, Mena Lora AJ, Mathews G, Mylonakis E, Murray TA, Sandkovsky U, Paredes R, Ramachandruni S, Reilly C, Vock D, Williamson JC, Young BE, Self WH, Lundgren J, Holland TL, Clin Microbiol Infect 2025 Jun 31 6 1053-1060 Evaluation of the Feasibility and Efficacy of Point-of-Care Antibody Tests for Biomarker-Guided Management of Coronavirus Disease 2019. Reilly C, Mylonakis E, Dewar R, Young B, Nordwall J, Bhagani S, Chia PY, Davis R, Files C, Ginde AA, Hatlen T, Helleberg M, Hayanga A, Jensen TO, Jain MK, Kalomenidis I, Kim K, Lallemand P, Lindegaard B, Menon A, Ognenovska K, Poulakou G, Thorup Røge B, Rogers AJ, Shaw-Saliba K, Sandkovsky U, Trautner BW, Vasudeva SS, Vekstein A, Viens K, Wyncoll J, DuChateau B, Zhang Z, Wu S, Babiker AG, Davey V, Gelijns A, Higgs E, Kan V, Lundgren J, Matthews GV, Lane HC, J Infect Dis 2025 Mar 231 3 677-683 Viral and Host Factors Are Associated With Mortality in Hospitalized Patients With COVID-19. Aggarwal NR, Nordwall J, Braun DL, Chung L, Coslet J, Der T, Eriobu N, Ginde AA, Hayanga AJ, Highbarger H, Holodniy M, Horcajada JP, Jain MK, Kim K, Laverdure S, Lundgren J, Natarajan V, Nguyen HH, Pett SL, Phillips A, Poulakou G, Price DA, Robinson P, Rogers AJ, Sandkovsky U, Shaw-Saliba K, Sturek JM, Trautner BW, Waters M, Reilly C, Clin Infect Dis 2024 Jun 78 6 1490-1503 Native mitral valve endocarditis due to Corynebacterium striatum, an uncommon pathogen. Sloan B, Duhaime E, Sandkovsky U, Proc (Bayl Univ Med Cent) 2024 37 1 151-153 Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial. Brown SM, Barkauskas CE, Grund B, Sharma S, Phillips AN, Leither L, Peltan ID, Lanspa M, Gilstrap DL, Mourad A, Lane K, Beitler JR, Serra AL, Garcia I, Almasri E, Fayed M, Hubel K, Harris ES, Middleton EA, Barrios MAG, Mathews KS, Goel NN, Acquah S, Mosier J, Hypes C, Salvagio Campbell E, Khan A, Hough CL, Wilson JG, Levitt JE, Duggal A, Dugar S, Goodwin AJ, Terry C, Chen P, Torbati S, Iyer N, Sandkovsky US, Johnson NJ, Robinson BRH, Matthay MA, Aggarwal NR, Douglas IS, Casey JD, Hache-Marliere M, Georges Youssef J, Nkemdirim W, Leshnower B, Awan O, Pannu S, O'Mahony DS, Manian P, Awori Hayanga JW, Wortmann GW, Tomazini BM, Miller RF, Jensen JU, Murray DD, Bickell NA, Zatakia J, Burris S, Higgs ES, Natarajan V, Dewar RL, Schechner A, Kang N, Arenas-Pinto A, Hudson F, Ginde AA, Self WH, Rogers AJ, Oldmixon CF, Morin H, Sanchez A, Weintrob AC, Cavalcanti AB, Davis-Karim A, Engen N, Denning E, Taylor Thompson B, Gelijns AC, Kan V, Davey VJ, Lundgren JD, Babiker AG, Neaton JD, Lane HC, Lancet Respir Med 2023 Sep 11 9 791-803 Risk of Infections With Long-Term Left Ventricular Assist Device Support. Karnatak R, Sandkovsky U, Cureus 2023 Jul 15 7 e41412 Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery. Douin DJ, Siegel L, Grandits G, Phillips A, Aggarwal NR, Baker J, Brown SM, Chang CC, Goodman AL, Grund B, Higgs ES, Hough CL, Murray DD, Paredes R, Parmar M, Pett S, Polizzotto MN, Sandkovsky U, Self WH, Young BE, Babiker AG, Davey VJ, Kan V, Gelijns AC, Matthews G, Thompson BT, Lane HC, Neaton JD, Lundgren JD, Ginde AA, Am J Respir Crit Care Med 2022 Sep 206 6 730-739 Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial. Barkauskas C, Mylonakis E, Poulakou G, Young BE, Vock DM, Siegel L, Engen N, Grandits G, Mosaly NR, Vekstein AM, Rogers R, Shehadeh F, Kaczynski M, Mylona EK, Syrigos KN, Rapti V, Lye DC, Hui DS, Leither L, Knowlton KU, Jain MK, Marines-Price R, Osuji A, Overcash JS, Kalomenidis I, Barmparessou Z, Waters M, Zepeda K, Chen P, Torbati S, Kiweewa F, Sebudde N, Almasri E, Hughes A, Bhagani SR, Rodger A, Sandkovsky U, Gottlieb RL, Nnakelu E, Trautner B, Menon V, Lutaakome J, Matthay M, Robinson P, Protopapas K, Koulouris N, Kimuli I, Baduashvili A, Braun DL, Günthard HF, Ramachandruni S, Kidega R, Kim K, Hatlen TJ, Phillips AN, Murray DD, Jensen TO, Padilla ML, Accardi EX, Shaw-Saliba K, Dewar RL, Teitelbaum M, Natarajan V, Laverdure S, Highbarger HC, Rehman MT, Vogel S, Vallée D, Crew P, Atri N, Schechner AJ, Pett S, Hudson F, Badrock J, Touloumi G, Brown SM, Self WH, North CM, Ginde AA, Chang CC, Kelleher A, Nagy-Agren S, Vasudeva S, Looney D, Nguyen HH, Sánchez A, Weintrob AC, Grund B, Sharma S, Reilly CS, Paredes R, Bednarska A, Gerry NP, Babiker AG, Davey VJ, Gelijns AC, Higgs ES, Kan V, Matthews G, Thompson BT, Legenne P, Chandra R, Lane HC, Neaton JD, Lundgren JD, Ann Intern Med 2022 Sep 175 9 1266-1274 Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial. Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Goodman AL, Chang W, Dewar RL, Gerry NP, Higgs ES, Highbarger H, Murray DD, Murray TA, Natarajan V, Paredes R, Parmar MKB, Phillips AN, Reilly C, Rupert AW, Sharma S, Shaw-Saliba K, Sherman BT, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Davey VJ, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD, Ann Intern Med 2022 Feb 175 2 234-243 Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3). Murray DD, Babiker AG, Baker JV, Barkauskas CE, Brown SM, Chang CC, Davey VJ, Gelijns AC, Ginde AA, Grund B, Higgs E, Hudson F, Kan VL, Lane HC, Murray TA, Paredes R, Parmar MK, Pett S, Phillips AN, Polizzotto MN, Reilly C, Sandkovsky U, Sharma S, Teitelbaum M, Thompson BT, Young BE, Neaton JD, Lundgren JD, Clin Trials 2022 Feb 19 1 52-61 Results 1-10 of 59 1 2 3 4 5 Next Last Books Featured Books Current Concepts in the Treatment of HIV Infection with Focus on Brain Disease. In The Neurology of AIDS, Third Edition Sandkovsky U and Swindells S (2011). London, England, Oxford University Press Viral Infections After Intestinal Transplantation. In Contemporary Small Bowel Transplantation Florescu DF, Sandkovsky U (2018). Springer Honors & Awards Best Doctors in DallasD Magazine (2024) Best Doctors in DallasD Magazine (2022) FellowInfectious Diseases Society of America (2018) Investigator AwardHIV Medical Association (2015) Chancellor's Diversity AwardUniversity of Nebraska Medical Center (2012-2014) FellowAmerican College of Physicians (2011) Top Teacher AwardUniversity of Nebraska, Department of Internal Medicine (2011) Physicians Recognition AwardAmerican Medical Association (2009-2012) Professional Associations/Affiliations American College of Physicians Infectious Diseases Society of America
