Santiago Alvarez Arango, M.D., Ph.D. Titles and Appointments Assistant Professor School Medical School Department Internal Medicine | Pediatrics You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Santiago Alvarez Arango, M.D., Ph.D., is an Assistant Professor in the Departments of Internal Medicine and Pediatrics at UT Southwestern Medical Center and a member of its Division of Allergy & Immunology. Dr. Alvarez specializes in diagnosing and managing drug hypersensitivity reactions and addressing unverified drug allergy labels. Originally from Medellín, Colombia, Dr. Alvarez earned his medical degree from Universidad CES and completed internal medicine residency training at Albert Einstein College of Medicine in New York. He then obtained fellowship training in allergy and immunology at Johns Hopkins University School of Medicine. During his fellowship, he trained under renowned drug allergy expert N. Franklin Adkinson, M.D., and conducted research on drug allergy mechanisms in the Donald MacGlashan Lab. He also completed an NIH-funded T32 fellowship in Clinical Pharmacology and earned a doctoral degree in clinical investigation from the Johns Hopkins Bloomberg School of Public Health. Before joining UT Southwestern in 2025, Dr. Alvarez served as an Assistant Professor of Medicine and Pharmacology at Johns Hopkins, where he led a dedicated Drug Allergy clinic and co-directed the Center of Anaphylaxis and the Drug Development Unit. Dr. Alvarez focuses his research on understanding the mechanisms of drug allergies and advancing diagnostic methods. His work has been supported by prestigious awards, including the AAAAI Foundation Faculty Development Award and the KL2 Mentored Career Development Award. His research has been published in high-impact, peer-reviewed journals, including the New England Journal of Medicine and the Journal of Allergy and Clinical Immunology. Education Medical School Universidad CES (2011) Residency Jacobi Medical Center - Albert Einstein College of Medicine (2017), Internal Medicine Fellowship Johns Hopkins University School of Medicine (2020), Allergy & Immunology Fellowship Johns Hopkins University School of Medicine (2021), Clinical Pharmacology Graduate School Johns Hopkins Bloomberg School of Public Health (2024) Publications Featured Publications Defining Optimal Basophil Passive Sensitisation Parameters. Alvarez-Arango S, Dispenza MC, Chichester KL, MacGlashan DW, Clin Exp Allergy 2025 Jan 55 1 75-83 A Skin Testing Strategy for Non-IgE-Mediated Reactions Associated With Vancomycin. Lyu S, Oliver ET, Dispenza MC, Chichester KL, Hoffman J, MacGlashan DW, Adkinson NF, Phillips EJ, Alvarez-Arango S, J Allergy Clin Immunol Pract 2024 Nov 12 11 3025-3033.e6 Examining cefazolin utilization and perioperative anaphylaxis in patients with and without a penicillin allergy label: A cross-sectional study. Murphy ZR, Muzaffar AF, Massih SA, Klein EY, Dispenza MC, Fabre V, Hensley NB, Blumenthal KG, Alvarez-Arango S, J Clin Anesth 2024 Jun 94 111377 Non-IgE-Mediated Immediate Drug-Induced Hypersensitivity Reactions. Alvarez-Arango S, Kumar M, Chow TG, Sabato V, J Allergy Clin Immunol Pract 2024 May 12 5 1109-1119 Vancomycin Infusion Reaction - Moving beyond "Red Man Syndrome". Alvarez-Arango S, Ogunwole SM, Sequist TD, Burk CM, Blumenthal KG, N Engl J Med 2021 Apr 384 14 1283-1286 Results 1-5 of 5 1 Honors & Awards Faculty Development AwardAmerican Academy of Allergy, Asthma and Immunology (2023) Leaders in Health Care AwardThe Baltimore Business Journal (2020) Alfred Sommer Scholarship for Doctor of Philosophy in Clinical InvestigationJohns Hopkins University Bloomberg School of Public Health (2018) Professional Associations/Affiliations American College of Pharmacology College of Allergy, Asthma, and Immunology European Academy of Allergy and Clinical Immunology Pharmacogenomics Global Research Network
