Tania Ortiz Dominguez, M.D. - Faculty Profile

Biography

Dr. Ortiz completed her medical training in Mexico and her postgraduate studies at McGill University and Dalhousie University. She is an Associate Professor at the Department of Psychiatry at UT Southwestern, where she leads the Computational Psychiatry Program.

As an expert in bipolar disorder, her research focuses on understanding mood regulation and forecasting episodes of illness using mathematical models and wearable technology.

For her work, Dr. Ortiz has been presented with more than 15 awards in her career, including the Samuel Gershon Award by the International Society of Bipolar Disorders, and the Clinical Innovator of the Year by Digital Health Canada.

As a Principal Investigator, she has secured national and international funding from the National Institutes of Mental Health (NIMH), the Canadian Institutes for Health Research (CIHR), and the American Foundation for Suicide Prevention (AFSP).

Research Interest

Forecasting episodes of illness using mathematical models and wearable technology
Understanding mood regulation

Publications

Featured Publications

The futility of long-term predictions in bipolar disorder: mood fluctuations are the result of deterministic chaotic processes.: Ortiz A, Bradler K, Mowete M, MacLean S, Garnham J, Slaney C, Mulsant BH, Alda M, Int J Bipolar Disord 2021 Oct 9 1 30
Reduced heart rate variability is associated with higher illness burden in bipolar disorder.: Ortiz A, Bradler K, Moorti P, MacLean S, Husain MI, Sanches M, Goldstein BI, Alda M, Mulsant BH, J Psychosom Res 2021 Jun 145 110478
Nonlinear dynamics of mood regulation in unaffected first-degree relatives of bipolar disorder patients.: A O, K B, J G, C S, S M, M A, J Affect Disord 2019 Jan 243 274-279
Episode forecasting in bipolar disorder: Is energy better than mood?: Ortiz A, Bradler K, Hintze A, Bipolar Disord 2018 Jan
Nonlinear dynamics of mood regulation in bipolar disorder.: Ortiz A, Bradler K, Garnham J, Slaney C, Alda M, Bipolar Disord 2015 Mar 17 2 139-49
Beyond Step Count: Are We Ready to Use Digital Phenotyping to Make Actionable Individual Predictions in Psychiatry?: Ortiz A, Mulsant BH, J Med Internet Res 2024 Aug 26 e59826
Challenges in defining treatment-resistant mania in adults: A systematic review.: Gonzalez-Torres C, Mulsant BH, Husain MI, Alda M, Young RC, Ortiz A, Bipolar Disord 2024 Feb 26 1 7-21
A History of Suicide Attempt Is Associated with Increased Sympathetic Activation in Bipolar Disorder.: Ortiz A, Park Y, MacLean S, Husain MI, Sanches M, Ravindran A, Mulsant BH, Can J Psychiatry 2024 Feb 69 2 126-137
The Role of Daily Steps in the Treatment of Major Depressive Disorder: Secondary Analysis of a Randomized Controlled Trial of a 6-Month Internet-Based, Mindfulness-Based Cognitive Behavioral Therapy Intervention for Youth.: Dang K, Ritvo P, Katz J, Gratzer D, Knyahnytska Y, Ortiz A, Walters C, Attia M, Gonzalez-Torres C, Lustig A, Daskalakis Z, Interact J Med Res 2023 Dec 12 e46419
The Human Phenotype Ontology in 2024: phenotypes around the world.: Gargano MA, Matentzoglu N, Coleman B, Addo-Lartey EB, Anagnostopoulos AV, Anderton J, Avillach P, Bagley AM, Bakštein E, Balhoff JP, Baynam G, Bello SM, Berk M, Bertram H, Bishop S, Blau H, Bodenstein DF, Botas P, Boztug K, Cady J, Callahan TJ, Cameron R, Carbon SJ, Castellanos F, Caufield JH, Chan LE, Chute CG, Cruz-Rojo J, Dahan-Oliel N, Davids JR, de Dieuleveult M, de Souza V, de Vries BBA, de Vries E, DePaulo JR, Derfalvi B, Dhombres F, Diaz-Byrd C, Dingemans AJM, Donadille B, Duyzend M, Elfeky R, Essaid S, Fabrizzi C, Fico G, Firth HV, Freudenberg-Hua Y, Fullerton JM, Gabriel DL, Gilmour K, Giordano J, Goes FS, Moses RG, Green I, Griese M, Groza T, Gu W, Guthrie J, Gyori B, Hamosh A, Hanauer M, Hanušová K, He YO, Hegde H, Helbig I, Holasová K, Hoyt CT, Huang S, Hurwitz E, Jacobsen JOB, Jiang X, Joseph L, Keramatian K, King B, Knoflach K, Koolen DA, Kraus ML, Kroll C, Kusters M, Ladewig MS, Lagorce D, Lai MC, Lapunzina P, Laraway B, Lewis-Smith D, Li X, Lucano C, Majd M, Marazita ML, Martinez-Glez V, McHenry TH, McInnis MG, McMurry JA, Mihulová M, Millett CE, Mitchell PB, Moslerová V, Narutomi K, Nematollahi S, Nevado J, Nierenberg AA, Cajbiková NN, Nurnberger JI, Ogishima S, Olson D, Ortiz A, Pachajoa H, Perez de Nanclares G, Peters A, Putman T, Rapp CK, Rath A, Reese J, Rekerle L, Roberts AM, Roy S, Sanders SJ, Schuetz C, Schulte EC, Schulze TG, Schwarz M, Scott K, Seelow D, Seitz B, Shen Y, Similuk MN, Simon ES, Singh B, Smedley D, Smith CL, Smolinsky JT, Sperry S, Stafford E, Stefancsik R, Steinhaus R, Strawbridge R, Sundaramurthi JC, Talapova P, Tenorio Castano JA, Tesner P, Thomas RH, Thurm A, Turnovec M, van Gijn ME, Vasilevsky NA, Vlcková M, Walden A, Wang K, Wapner R, Ware JS, Wiafe AA, Wiafe SA, Wiggins LD, Williams AE, Wu C, Wyrwoll MJ, Xiong H, Yalin N, Yamamoto Y, Yatham LN, Yocum AK, Young AH, Yüksel Z, Zandi PP, Zankl A, Zarante I, Zvolský M, Toro S, Carmody LC, Harris NL, Munoz-Torres MC, Danis D, Mungall CJ, Köhler S, Haendel MA, Robinson PN, Nucleic Acids Res 2023 Nov

Honors & Awards

Clinical Innovator of the Year, Digital Health Canada
(2023)
Samuel Gershon Award for Junior Investigators, International Society for Bipolar Disorders
This is a prestigious award for the best research paper in the field of bipolar disorder by a junior researcher. The award was given for a paper on the mathematical modeling of sleep trajectories in bipolar disorder. (2016)

Professional Associations/Affiliations

ACNP Underrepresented Minority Task Force (2014)
Canadian College of Psychopharmacology (2010)
International Group for the Study of Lithium (IGSLi) (2023)
International Mood Network (2016)
International Society for Bipolar Disorders (2012)
Royal College of Physicians and Surgeons of Canada (2012)
Society for Biological Psychiatry (2017)
Society for Chaos Theory in Psychology and Life Sciences (2022)