Brittany Weber, M.D., Ph.D.

Brittany Weber, M.D., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern and a member of its Division of Cardiology. A cardio-immunologist, clinical investigaor, and imaging specialist, her work spans cardiology, rheumatology, immunology, and infectous disease. He research integrates advanced imaging, molecular biology, clinical trials, and population health to undersand how systemic inflammation, immune deregulation, and viral infections drive cardiovascular disease. She serves as Director of the Cardio-Rheumatology/Cardio-Dermatology Program.

Originally from Arkansas, Dr. Weber holds a bachelor’s degree in biomedical science-zoology from the University of Oklahoma in Norman. She earned her medical degree from the University of Pennsylvania, where she also earned and her doctoral degree in immunology. She completed internal medicine residency training at Brigham and Women’s Hospital (BWH), where she served as Chief Resident. She also obtained advanced training at BWH through fellowship programs in cardiology and in cardiovascular imaging.

Prior to joining the UT Southwestern faculty in 2025, Dr. Weber served on the faculty at Harvard Medical School and Director of the Cardio-rheumatology Clinic at BWH, a nationally recognized clinic that integrates cardiovascular care with rheumatologic expertise, addressing inflammation-related heart disease through collaborative, patient-centered care.

Dr. Weber’s research centers on the intersection of cardiology, rheumatology, and immunology, with a focus on how systemic inflammation and autoimmune diseases (such as rheumatoid arthritis, lupus, psoriasis, vasculitis, and inflammatory bowel disease) contribute to cardiovascular dysfunction, including coronary microvascular disease, myocardial injury, and heart failure. She integrates advanced imaging techniques (PET, SPECT, MRI, OCTA) with biomarker analysis, clinical trials, and population health studies to uncover mechanisms of disease and improve risk prediction. Her work also spans COVID-19-related cardiac complications, lipoprotein(a) and thrombosis, drug safety, and women’s cardiovascular health.

Dr. Weber pioneered several clinical innovations that bridge education, technology, and multidisciplinary care. During her residency at Brigham and Women’s Hospital, she co-founded the SiR: Science in Residency program, a novel training track that integrates clinical excellence with basic and translational research, fostering scientific inquiry among internal medicine residents. She also led the development of a bedside teaching initiative using electronic stethoscopes, enabling real-time auscultation education and earning support from Microsoft and a Medical Innovation Grant. 

Dr. Weber's work is widely published in top-tier medical journals, including Nature, The New England Journal of Medicine, the Journal of the American College of Cardiology, the Journal of the American Heart Association, BMJ Open, and Hypertension, reflecting the high impact and interdisciplinary relevance of her work. Her studies span from molecular immunology to advanced cardiovascular imaging and clinical innovation, earning her recognition as a thought leader in cardio-immunology. As a result, she is frequently invited to speak at national and international conferences, where she shares insights on inflammation-driven cardiovascular disease, autoimmune conditions, and translational care models that integrate cardiology and rheumatology.