Jonathan Mosley, M.D., Ph.D. Titles and Appointments Associate Professor School Medical School Department Internal Medicine | Eugene McDermott Center for Human Growth and Development You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Jonathan D. Mosley, M.D., Ph.D., is a clinically trained physician scientist and associate professor in the Department of Internal Medicine at UT Southwestern Medical Center. He has a Master’s in Science in Chronic Disease Epidemiology from the Johns Hopkins Bloomberg School of Public Health and completed an M.D./Ph.D. program at Case Western Reserve University, where his thesis work focused on molecular and mouse models of mammary gland tumorigenesis. Dr. Mosley completed a residency in Internal Medicine at Vanderbilt University Medical Center. His clinical focus is on the diagnosis and treatment of resistant hypertension. He is a Fellow of the American Heart Association and a member of the American Society of Human Genetics. Dr. Mosley’s research focus is on the translation of complex genetics to clinical medicine with the goal of improving health care delivery, reducing unnecessary health care utilization, and improving risk stratification. In particular, he focuses on developing, evaluating and implementing polygenic methods to guide clinical decision-making, to inform clinical risk prediction and to delineate the etiological relationships between diverse human diseases and putative biomarkers. Much of this work leverages large clinical and epidemiological data resources including electronic health records (EHR)-linked to DNA biobanks. One area of interest is how “benign” genetic variation in clinical biomarkers creates vulnerable populations that are predisposed to iatrogenic harms. Other areas of focus include metabolomics, proteomics prostate cancer, and cardiac disease. Research Interest Complex human genetics Epidemiology Health inequities Risk factors Publications Featured Publications A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature. Shelley JP, Shi M, Peterson JF, Van Driest SL, Simmons JH, Mosley JD, Genome Med 2025 Mar 17 1 23 Clinical associations with a polygenic predisposition to benign lower white blood cell counts. Mosley JD, Shelley JP, Dickson AL, Zanussi J, Daniel LL, Zheng NS, Bastarache L, Wei WQ, Shi M, Jarvik GP, Rosenthal EA, Khan A, Sherafati A, Kullo IJ, Walunas TL, Glessner J, Hakonarson H, Cox NJ, Roden DM, Frangakis SG, Vanderwerff B, Stein CM, Van Driest SL, Borinstein SC, Shu XO, Zawistowski M, Chung CP, Kawai VK, Nat Commun 2024 Apr 15 1 3384 Branched-chain amino acids and type 2 diabetes: a bidirectional Mendelian randomization analysis. Mosley JD, Shi M, Agamasu D, Vaitinadin NS, Murthy VL, Shah RV, Bagheri M, Ferguson JF, Obesity (Silver Spring) 2024 Feb 32 2 423-435 Identification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size. Agrawal V, Manouchehri A, Vaitinadin NS, Shi M, Bagheri M, Gupta DK, Kullo IJ, Luo Y, McNally EM, Puckelwartz MJ, Ferguson JF, Wells QS, Mosley JD, Circ Heart Fail 2024 Jan 17 1 e010557 Clinical consequences of a genetic predisposition toward higher benign prostate-specific antigen levels. Shi M, Shelley JP, Schaffer KR, Tosoian JJ, Bagheri M, Witte JS, Kachuri L, Mosley JD, EBioMedicine 2023 Nov 97 104838 Coronary Artery Calcium Score and Polygenic Risk Score for the Prediction of Coronary Heart Disease Events. Khan SS, Post WS, Guo X, Tan J, Zhu F, Bos D, Sedaghati-Khayat B, van Rooij J, Aday A, Allen NB, Bos MM, Uitterlinden AG, Budoff MJ, Lloyd-Jones DM, Mosley JD, Rotter JI, Greenland P, Kavousi M, JAMA 2023 May 329 20 1768-1777 A Polygenic Risk Score for Prostate Cancer Risk Prediction. Schaffer KR, Shi M, Shelley JP, Tosoian JJ, Kachuri L, Witte JS, Mosley JD, JAMA Intern Med 2023 Apr 183 4 386-388 White blood cell ranges and frequency of neutropenia by Duffy genotype status. Bagheri M, Chung CP, Dickson AL, Van Driest SL, Borinstein SC, Mosley JD, Blood Adv 2023 Feb 7 3 406-409 Race, Genotype, and Azathioprine Discontinuation : A Cohort Study. Dickson AL, Daniel LL, Jackson E, Zanussi J, Yang W, Plummer WD, Dupont WD, Wei WQ, Nepal P, Hung AM, Cox NJ, Van Driest SL, Feng Q, Yang JJ, Stein CM, Mosley JD, Chung CP, Ann Intern Med 2022 Aug 175 8 1092-1099 Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients. Van Driest SL, Abul-Husn NS, Glessner JT, Bastarache L, Nirenberg S, Schildcrout JS, Eswarappa MS, Belbin GM, Shaffer CM, Mentch F, Connolly J, Shi M, Stein CM, Roden DM, Hakonarson H, Cox NJ, Borinstein SC, Mosley JD, JAMA Intern Med 2021 Aug 181 8 1100-1105 Results 1-10 of 15 1 2 Next Last Honors & Awards Chancellors award for Research in Diversity, Equity and Inclusion (VUMC) (2024) Clinical Pharmacology Faculty Teaching Award (2023) Circulation outstanding reviewer recognition (2022) Clinical Pharmacology Faculty Teaching Award (2021) Top 10 genomic medicine papersManuscript selected among top 10 genomic medicine papers by the Genomic Medicine Working Group, National Advisory Council of NHGRI (2021)
