Research Interest

  • Brain Development
  • Cancer Biology
  • Medulloblastoma
  • Pediatric Low-Grade Glioma and Optic Pathway Glioma
  • Peripheral Nerve Sheath Tumors
  • Stem Cell Biology


Featured Publications LegendFeatured Publications

Stem-Like Cell Populations, p53-Pathway Activation and Mechanisms of Recurrence in Sonic Hedgehog Medulloblastoma.
Treisman D, Li Y, Zhu Y, Neuromolecular Med 2022 Mar 24 1 13-17
Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors.
Jecrois ES, Zheng W, Bornhorst M, Li Y, Treisman DM, Muguyo D, Huynh S, Andrew SF, Wang Y, Jiang J, Pierce BR, Mao H, Krause MK, Friend A, Nadal-Nicolas F, Stasheff SF, Li W, Zong H, Packer RJ, Zhu Y, Dev Cell 2021 Oct 56 20 2871-2885.e6
A therapeutic window for preventive therapy in NF1-associated optic pathway glioma.
Zhu Y, Zheng W, Jecrois ES, Pierce BR, Treisman DM, Mol Cell Oncol 2021 8 6 1989262
Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution.
Li Y, Li B, Li W, Wang Y, Akgül S, Treisman DM, Heist KA, Pierce BR, Hoff B, Ho CY, Ferguson DO, Rehemtulla A, Zheng S, Ross BD, Li JZ, Zhu Y, Nat Commun 2020 Jul 11 1 3669
Sox2+ cells in Sonic Hedgehog-subtype medulloblastoma resist p53-mediated cell-cycle arrest response and drive therapy-induced recurrence.
Treisman DM, Li Y, Pierce BR, Li C, Chervenak AP, Tomasek GJ, Lozano G, Zheng X, Kool M, Zhu Y, Neurooncol Adv 2019 1 1 vdz027
Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.
Akgül S, Li Y, Zheng S, Kool M, Treisman DM, Li C, Wang Y, Gröbner S, Ikenoue T, Shen Y, Camelo-Piragua S, Tomasek G, Stark S, Guduguntla V, Gusella JF, Guan KL, Pfister SM, Verhaak RGW, Zhu Y, Cell Rep 2018 Jul 24 2 463-478.e5
Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition.
Clark PA, Iida M, Treisman DM, Kalluri H, Ezhilan S, Zorniak M, Wheeler DL, Kuo JS, Neoplasia 2012 May 14 5 420-8
The cancer stem cell paradigm: a new understanding of tumor development and treatment.
Ebben JD, Treisman DM, Zorniak M, Kutty RG, Clark PA, Kuo JS, Expert Opin Ther Targets 2010 Jun 14 6 621-32
Developmental signaling pathways in brain tumor-derived stem-like cells.
Clark PA, Treisman DM, Ebben J, Kuo JS, Dev Dyn 2007 Dec 236 12 3297-308