Wojciech Lesniak, Ph.D. Assistant Professor School Medical School Department Radiology Biography Wojciech G. Lesniak, Ph.D., is an Assistant Professor at UT Southwestern Medical Center in The Department of Radiology and a member of its Research Division. Originally from Glucholazy, Poland, Dr. Lesniak received his doctorate degree in Bioinorganic and Biomedical Chemistry from University of Wroclaw in Wroclaw, Poland. He then received advanced training as a Fellow at the Kresge Hearing Research Institute and Department of Chemistry at University of Michigan in Ann, Arbor, Michigan, followed by a fellowship at the Department of Internal Medicine in the Michigan Nanotechnology Institute for Medicine and Biological Sciences at University of Michigan in Ann Arbor, Michigan. He also served as a Fellow at the Department of Ophthalmology in the Center of Nanomedicine at Johns Hopkins School of Medicine in Baltimore, Maryland. Additionally, he completed the Science of Clinical Investigation Training Program at Johns Hopkins Bloomberg School of Public Health in Baltimore, Maryland. Before joining the faculty in 2024, Dr. Lesniak served as Director of the Radiometabolite Laboratory in the PET Center, and as an instructor, both within the Russel H. Morgan Department of Radiology and Radiological Science at Johns Hopkins University School of Medicine. Dr. Lesniak focuses his research on the development of molecular imaging and theranostic agents for diagnosing and treating cancer and central nervous system diseases. He is particularly interested in imaging-guided cancer-targeted drug delivery, which provides crucial information to enhance therapeutic responses. By integrating advanced imaging modalities with targeted drug delivery systems, he aims to improve the precision and efficacy of treatments, ultimately contributing to personalized medicine approaches in oncology and neurology. His work has resulted in more than 90 peer-reviewed publications in scientific journals and presentations at professional conferences throughout the world. Dr. Lesniak is an active member of several professional organizations, including the Material Research Society, the World Molecular Imaging Congress, and the Controlled Release Society. During his spare time, Dr. Lesniak enjoys skiing, hiking, and all water sports. Research Interest Development of novel dendrimer-based theranostic agents for management of prostate cancer Development of PET radiotracers for tau proteins, alpha7-nicotinic receptor, activated microglia cells Publications Featured Publications Beyond synthetic aperture focusing: deconvolution-based elevation resolution enhancement using simulated point spread function for linear array-based three-dimensional photoacoustic imaging. Tang Y, Lesniak WG, Gao S, Wu Y, Pomper MG, Zhang HK, Biomed Opt Express 2024 Mar 15 3 1847-1860 Multimodal, PSMA-Targeted, PAMAM Dendrimer-Drug Conjugates for Treatment of Prostate Cancer: Preclinical Evaluation. Lesniak WG, Boinapally S, Lofland G, Jiang Z, Foss CA, Behman Azad B, Jablonska A, Garcia MA, Brzezinski M, Pomper MG, Int J Nanomedicine 2024 19 4995-5010 In-bore MRI-compatible Transrectal Ultrasound and Photoacoustic Imaging. Murakami R, Wang Y, Lesniak WG, Tsumura R, Tang Y, Tsunoi Y, Nycz CJ, Pomper MG, Fischer GS, Zhang HK, bioRxiv 2023 Nov [18F]FNDP PET neuroimaging test-retest repeatability and whole-body dosimetry in humans. Du Y, Coughlin JM, Amindarolzarbi A, Sweeney SE, Harrington CK, Brosnan MK, Zandi A, Shinehouse LK, Sanchez ANR, Abdallah R, Holt DP, Fan H, Lesniak WG, Nandi A, Rowe SP, Solnes LB, Dannals RF, Horti AG, Lodge MA, Pomper MG, Eur J Nucl Med Mol Imaging 2023 Oct 50 12 3659-3665 Pilot imaging of the colony stimulating factor 1 receptor in the brains of virally-suppressed individuals with HIV. Rubin LH, Du Y, Sweeney SE, O'Toole R, Harrington CK, Jenkins K, Lesniak WG, Veenhuis RT, Dastgheyb R, Severson J, Fan H, Holt DP, Hall AW, Dannals RF, Horti AG, Pomper MG, Coughlin JM, AIDS 2023 Jul 37 9 1419-1424 First-in-human imaging using [11C]MDTC: a radiotracer targeting the cannabinoid receptor type 2. Du Y, Coughlin JM, Brosnan MK, Chen A, Shinehouse LK, Abdallah R, Lodge MA, Mathews WB, Liu C, Wu Y, Minn I, Finley P, Hall AW, Lesniak WG, Dannals RF, Horti AG, Pomper MG, Eur J Nucl Med Mol Imaging 2023 Jul 50 8 2386-2393 System-level optimization in spectroscopic photoacoustic imaging of prostate cancer. Wu Y, Kang J, Lesniak WG, Lisok A, Zhang HK, Taylor RH, Pomper MG, Boctor EM, Photoacoustics 2022 Sep 27 100378 An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications. Lesniak WG, Azad BB, Chatterjee S, Lisok A, Pomper MG, Pharmaceutics 2022 Mar 14 3 Dual-Modality PET-SPECT Image-Guided Pretargeting Delivery in HER2(+) Breast Cancer Models. Hapuarachchige S, Si G, Huang CT, Lesniak WG, Mease RC, Guo X, Gabrielson K, Artemov D, Biomacromolecules 2021 Nov 22 11 4606-4617 First-in-human neuroimaging of soluble epoxide hydrolase using [18F]FNDP PET. Coughlin JM, Slania S, Du Y, Shinehouse LK, Brosnan MK, Azad BB, Holt DP, Fan H, Lesniak WG, Minn I, Rowe SP, Dannals RF, Horti AG, Pomper MG, Eur J Nucl Med Mol Imaging 2021 Sep 48 10 3122-3128 Results 1-10 of 64 1 2 3 4 5 Next Last Books Featured Books Composite nanoparticles for cancer imaging and therapy: engineering surface, composition and shape. In Nanomedicine Design of Particles, Sensors Motors, Implants Robots and Devices Balogh LP, Ould-Ely T, Lesniak WG (2009). Artech House, Inc. Professional Associations/Affiliations Association for Research in Otolaryngology (2001-2003) Controlled Release Society (2023) Material Research Society (2004) World Molecular Imaging Congress (2015)
