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Fangyu Liu, Ph.D.

Fangyu Liu, Ph.D.

Titles and Appointments

Assistant Professor

Endowed Title
Endowed Scholar in Medical Science
School
Medical School
Department
Pharmacology
  • Research Interest
    • The overarching goal of the lab is to redefine membrane enzymology. Membrane enzymes are intricate protein machineries that catalyze reactions within the membrane. Compared to other membrane proteins, membrane enzymes remain relatively understudied, limiting their potential as therapeutic targets. This gap in knowledge arises from their inherent functional complexities. The lab aims to overcome these challenges by developing specific probes to better understand these enzymes.
  • Publications

    Star Featured Publications

    The impact of library size and scale of testing on virtual screening.
    Liu F, Mailhot O, Glenn IS, Vigneron SF, Bassim V, Xu X, Fonseca-Valencia K, Smith MS, Radchenko DS, Fraser JS, Moroz YS, Irwin JJ, Shoichet BK, Nat Chem Biol 2025 Jan
    Large library docking identifies positive allosteric modulators of the calcium-sensing receptor.
    Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G, Science 2024 Sep 385 6715 eado1868
    Molecular structures of the eukaryotic retinal importer ABCA4.
    Liu F, Lee J, Chen J, Elife 2021 Feb 10
    Structural identification of a hotspot on CFTR for potentiation.
    Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J, Science 2019 Jun 364 6446 1184-1188
    Molecular structure of the ATP-bound, phosphorylated human CFTR.
    Zhang Z, Liu F, Chen J, Proc Natl Acad Sci U S A 2018 Dec 115 50 12757-12762
    Conformational Changes of CFTR upon Phosphorylation and ATP Binding.
    Zhang Z, Liu F, Chen J Cell 2017 Jul 170 3 483-491.e8
    Molecular Structure of the Human CFTR Ion Channel.
    Liu F, Zhang Z, Csanády L, Gadsby DC, Chen J, Cell 2017 Mar 169 1 85-95.e8
  • Honors & Awards
    • CPRIT Scholar (Cancer Prevention and Research Institute of Texas)
      (2025)
    • Endowed Scholar in Medical Science
      (2025)
    • Damon Runyon Postdoctoral Fellowship
      (2020-2024)