Fangyu Liu, Ph.D.

Assistant Professor

Endowed Title: Deborah and W. A. "Tex" Moncrief, Jr. Scholar in Medical Research; Endowed Scholar in Medical Science
School: Medical School
Department: Pharmacology

Research Interest

The overarching goal of the lab is to redefine membrane enzymology. Membrane enzymes are intricate protein machineries that catalyze reactions within the membrane. Compared to other membrane proteins, membrane enzymes remain relatively understudied, limiting their potential as therapeutic targets. This gap in knowledge arises from their inherent functional complexities. The lab aims to overcome these challenges by developing specific probes to better understand these enzymes.

Publications

Featured Publications

The impact of library size and scale of testing on virtual screening.: Liu F, Mailhot O, Glenn IS, Vigneron SF, Bassim V, Xu X, Fonseca-Valencia K, Smith MS, Radchenko DS, Fraser JS, Moroz YS, Irwin JJ, Shoichet BK, Nat Chem Biol 2025 Jan
Large library docking identifies positive allosteric modulators of the calcium-sensing receptor.: Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G, Science 2024 Sep 385 6715 eado1868
Molecular structures of the eukaryotic retinal importer ABCA4.: Liu F, Lee J, Chen J, Elife 2021 Feb 10
Structural identification of a hotspot on CFTR for potentiation.: Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J, Science 2019 Jun 364 6446 1184-1188
Molecular structure of the ATP-bound, phosphorylated human CFTR.: Zhang Z, Liu F, Chen J, Proc Natl Acad Sci U S A 2018 Dec 115 50 12757-12762
Conformational Changes of CFTR upon Phosphorylation and ATP Binding.: Zhang Z, Liu F, Chen J Cell 2017 Jul 170 3 483-491.e8
Molecular Structure of the Human CFTR Ion Channel.: Liu F, Zhang Z, Csanády L, Gadsby DC, Chen J, Cell 2017 Mar 169 1 85-95.e8

Honors & Awards