Shixuan Liu, Ph.D.

• 1) Seasonal and circadian clocks
• 2) Primate biology and disease modeling
• 3) Cell and organ size control

 Featured Publications

A molecular cell atlas of mouse lemur, an emerging model primate.

Ezran C, Liu S, Chang S, Ming J, Botvinnik O, Penland L, Tarashansky A, de Morree A, Travaglini KJ, Zhao J, Wang G, Hasegawa K, Sin H, Sit R, Okamoto J, Sinha R, Zhang Y, Karanewsky CJ, Pendleton JL, Morri M, Perret M, Aujard F, Stryer L, Artandi S, Fuller MT, Weissman IL, Rando TA, Ferrell JE, Wang B, De Vlaminck I, Yang C, Casey KM, Albertelli MA, Pisco AO, Karkanias J, Neff N, Wu AR, Quake SR, Krasnow MA, Nature 2025 Jul

Mouse lemur cell atlas informs primate genes, physiology and disease.

Ezran C, Liu S, Chang S, Ming J, Guethlein LA, Wang MFZ, Dehghannasiri R, Olivieri J, Frank HK, Tarashansky A, Koh W, Jing Q, Botvinnik O, Antony J, Pisco AO, Karkanias J, Yang C, Ferrell JE, Boyd SD, Parham P, Long JZ, Wang B, Salzman J, De Vlaminck I, Wu AR, Quake SR, Krasnow MA, Nature 2025 Jul

An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome.

Liu S, Ezran C, Wang MFZ, Li Z, Awayan K, Long JZ, De Vlaminck I, Wang S, Epelbaum J, Kuo CS, Terrien J, Krasnow MA, Ferrell JE, Nat Commun 2024 Mar 15 1 2188

In vivo self-renewal and expansion of quiescent stem cells from a non-human primate.

Kang J, Kanugovi A, Stella MPJ, Frimand Z, Farup J, Urtasun A, Liu S, Clausen AS, Ishak H, Bui S, Kim S, Ezran C, Botvinnik O, Porpiglia E, Krasnow MA, de Morree A, Rando TA, Nat Commun 2025 Jun 16 1 5370

Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis.

Liu S, Tan C, Melo-Gavin C, Ginzberg MB, Blutrich R, Patel N, Rape M, Mark KG, Kafri R, Elife 2025 Jan 14

Cellular and molecular characterization of peripheral glia in the lung and other organs.

Hall S, Liu S, Liang I, Schulz S, Ezran C, Tan M, Kuo CS, PLoS One 2024 19 12 e0310303

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans.

Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, Aaron KA, Concepcion W, Gardner JM, Kelly B, Neidlinger N, Wang Z, Crasta S, Kolluru S, Morri M, Pisco AO, Tan SY, Travaglini KJ, Xu C, Alcántara-Hernández M, Almanzar N, Antony J, Beyersdorf B, Burhan D, Calcuttawala K, Carter MM, Chan CKF, Chang CA, Chang S, Colville A, Crasta S, Culver RN, Cvijovic I, D'Amato G, Ezran C, Galdos FX, Gillich A, Goodyer WR, Hang Y, Hayashi A, Houshdaran S, Huang X, Irwin JC, Jang S, Juanico JV, Kershner AM, Kim S, Kiss B, Kolluru S, Kong W, Kumar ME, Kuo AH, Leylek R, Li B, Loeb GB, Lu WJ, Mantri S, Markovic M, McAlpine PL, de Morree A, Morri M, Mrouj K, Mukherjee S, Muser T, Neuhöfer P, Nguyen TD, Perez K, Phansalkar R, Pisco AO, Puluca N, Qi Z, Rao P, Raquer-McKay H, Schaum N, Scott B, Seddighzadeh B, Segal J, Sen S, Sikandar S, Spencer SP, Steffes LC, Subramaniam VR, Swarup A, Swift M, Travaglini KJ, Van Treuren W, Trimm E, Veizades S, Vijayakumar S, Vo KC, Vorperian SK, Wang W, Weinstein HNW, Winkler J, Wu TTH, Xie J, Yung AR, Zhang Y, Detweiler AM, Mekonen H, Neff NF, Sit RV, Tan M, Yan J, Bean GR, Charu V, Forgó E, Martin BA, Ozawa MG, Silva O, Tan SY, Toland A, Vemuri VNP, Afik S, Awayan K, Botvinnik OB, Byrne A, Chen M, Dehghannasiri R, Detweiler AM, Gayoso A, Granados AA, Li Q, Mahmoudabadi G, McGeever A, de Morree A, Olivieri JE, Park M, Pisco AO, Ravikumar N, Salzman J, Stanley G, Swift M, Tan M, Tan W, Tarashansky AJ, Vanheusden R, Vorperian SK, Wang P, Wang S, Xing G, Xu C, Yosef N, Alcántara-Hernández M, Antony J, Chan CKF, Chang CA, Colville A, Crasta S, Culver R, Dethlefsen L, Ezran C, Gillich A, Hang Y, Ho PY, Irwin JC, Jang S, Kershner AM, Kong W, Kumar ME, Kuo AH, Leylek R, Liu S, Loeb GB, Lu WJ, Maltzman JS, Metzger RJ, de Morree A, Neuhöfer P, Perez K, Phansalkar R, Qi Z, Rao P, Raquer-McKay H, Sasagawa K, Scott B, Sinha R, Song H, Spencer SP, Swarup A, Swift M, Travaglini KJ, Trimm E, Veizades S, Vijayakumar S, Wang B, Wang W, Winkler J, Xie J, Yung AR, Artandi SE, Beachy PA, Clarke MF, Giudice LC, Huang FW, Huang KC, Idoyaga J, Kim SK, Krasnow M, Kuo CS, Nguyen P, Quake SR, Rando TA, Red-Horse K, Reiter J, Relman DA, Sonnenburg JL, Wang B, Wu A, Wu SM, Wyss-Coray T, Science 2022 May 376 6594 eabl4896

Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets.

Zhao J, Wang G, Ming J, Lin Z, Wang Y, The Tabula Microcebus Consortium, Wu AR, Yang C, Nat. Comput. Sci. 2022 2 317–330

FIRM: Flexible integration of single-cell RNA-sequencing data for large-scale multi-tissue cell atlas datasets.

Ming J, Lin Z, Zha J, Wan X, The Tabula Microcebus Consortium, Yang C, Wu AR, Brief. Bioinformatics 2022 23 5 bbac167

Cell types of origin of the cell-free transcriptome.

Vorperian SK, Moufarrej MN, The Tabula Sapiens Consortium, Quake SR, Nat. Biotechnol. 2022 40 6 855-861

• CPRIT Scholar Award
  Cancer Prevention & Research Institute of Texas (2025)
• Endowed Scholar Award
  UT Southwestern Medical Center (2025)
• Interdisciplinary Scholar Award
  Stanford Wu Tsai Neurosciences Institute (2020-2021)
• Visiting Junior Scholar Fellowship
  The France-Stanford Center for Interdisciplinary Studies (2020)
• Restracomp Graduate Fellowship
  Sickkids Research Institute (2014-2018)