Jennifer Coughlin, M.D. Professor Endowed Title Communities Foundation of Texas, Inc. Chair in Brain Science School Medical School Department Psychiatry | Peter O'Donnell Jr. Brain Institute You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Dr. Jennifer Coughlin is Professor and Director of the Molecular Imaging in the Psychiatry Program at UTSW Medical Center. She holds an adjunct appointment at the Johns Hopkins University. Her clinical expertise is in the diagnosis and treatment of mood disorders, with particular specialty in the young adult population. Dr. Coughlin’s research focuses on molecular neuroimaging techniques, particularly the use of novel radiotracers with positron emission tomography (PET). Recent research has focused on the contribution of the neuroimmune response to neurologic and psychiatric conditions spanning study of repeated, sports-related traumatic brain injury, psychosis, treatment-resistant mood disorders, Alzheimer’s disease, and healthy aging. She aims to inform the molecular understanding of neuropsychiatric conditions, and identify novel, precision therapies guided by imaging results. Research Interest Bipolar Disorder Cholinergic signaling Inflammation Magnetic Resonance Spectroscopy Mild Cognitive Impairment due to Alzheimer's Disease Positron Emission Tomography Psychosis (Schizophrenia, Schizoaffective Disorder) Traumatic Brain Injury Treatment-resistant Major Depressive Disorder Publications Featured Publications Hippocampal Availability of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis Wong NR, Rubin LH, Harrington CK, Jenkins KR, Shinehouse LK, Yoon M, Kilgore JJ, Soule AR, Lesniak WG, Rowe SP, Horti AG, Kamath V, Dannals RF, Du Y, Pomper MG, Coughlin JM 2024 Imaging brain injury in former National Football League players Rubin LH, Du Y, Sweeney SE, et al. JAMA Network Open 2023 [18F]FNDP PET Neuroimaging Test-Retest Repeatability and Whole Body Dosimetry in Humans Du Y, Coughlin JM, Amindarolzarbi A, Sweeney SE, Harrington CK, Brosnan MK, Zandi A, Shinehouse LK, Reyes Sanchez AN, Abdallah R, Holt DP, Fan H, Lesniak WG, Nandi A, Rowe SP, Solnes LB, Dannals RF, Horti AG, Lodge MA, Pomper MG EJNMMI 2023 Pilot imaging of the colony stimulating factor 1 receptor in the brains of virally-suppressed individuals with HIV Rubin LH, Du Y, Sweeney SE, OToole R, Harrington CK, Jenkins K, Lesniak WG, Veenhuis RT, Dastgheyb R, Severson J, Fan H, Holt DP, Hall AW, Dannals RF, Horti AG, Pomper MG, Coughlin JM AIDS 2023 First in Human Imaging Using [11C]MDTC, A Radiotracer Targeting the Cannabinoid Receptor Type 2 Du Y, Coughlin JM, Brosnan MK, Chen A, Shinehouse LK, Abdallah R, Lodge MA, Mathews WB, Liu C, Wu Y, Minn I, Finley P, Hall AW, Lesniak WG, Dannals RF, Horti AG, Pomper MG EJNMMI 2023 First-in-human use of [11C]CPPC with positron emission tomography for imaging the macrophage colony stimulating factor 1 receptor Coughlin JM, Du Y, Lesniak WG, Harrington CK, Brosnan MK, OToole R, Zandi A, Sweeney SE, Abdallah R, Wu Y, Holt DP, Hall AW, Dannals RF, Solnes L, Horti AG, Pomper MG EJNMMI 2022 First-in-human neuroimaging of soluble epoxide hydrolase using [18F]FNDP PET Coughlin JM, Slania S, Du Y, Shinehouse LK, Brosnan MK, Behnam Azad B, Holt DP, Fan H, Lesniak WG, Minn I, Rowe SP, Dannals RF, Horti AG, Pomper MG EJNMMI 2021 A multimodal approach to studying the relationship between peripheral glutathione, brain glutamate, and cognition in health and in schizophrenia Coughlin JM, Yang K, Marsman A, Pradhan S, Wang M, Ward RE, Bonekamp S, Ambinder EB, Higgs CP, Kim PK, Edwards JA, Varvaris M, Wang H, Posporelis S, Ma S, Tsujimura T, Edden RAE, Pomper MG, Sedlak T, Fournier M, Schretlen DJ, Cascella NG, Barker PB, Sawa A Mol Psychiatry 2021 Assessing Brain Metabolism With 7T Proton Magnetic Resonance Spectroscopy in Patients With First-Episode Psychosis Wang AM, Pradhan S, Coughlin JM, Trivedi A, DuBois SL, Crawford JL, Sedlak TW, Nucifora FC Jr, Nestadt G, Nucifora LG, Schretlen DJ, Sawa A, Barker PB JAMA Psychiatry 2019 High availability of the α7 nicotinic acetylcholine receptor in brains of individuals with mild cognitive impairment: a pilot study using [18F]ASEM PET Coughlin JM, Rubin LH, Du Y, Rowe SP, Crawford JL, Rosenthal HB, Frey SM, Marshall ES, Shinehouse LK, Chen A, Speck CL, Wang Y, Lesniak WG, Minn I, Bakker A, Kamath V, Smith GS, Albert MS, Behnam Azad B, Dannals RF, Horti A, Wong DF, Pomper MG J Nucl Med 2019 Results 1-10 of 17 1 2 Next Last Honors & Awards Elected Distinguished Fellow of the American Psychiatric Association (2023) Invited ParticipantRising Star Leadership Program, One Mind Foundation (2023) Research Best Paper 2023European Journal of Nuclear Medicine and Medical Imaging (EJNMMI) (2023) Selected ParticipantLeading Transformation for Value-based Health Care: Executive Education Program, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (2023-2024) Selected Participant2021-2022 Leadership Development Program, Johns Hopkins Medicine (2021) Defeating Depression AwardThe Hope for Depression Research Foundation (2020) Gifford Foundation Rising Star Schizophrenia Research AwardOne Mind (2019) Johns Hopkins University Catalyst Award (2018) Johns Hopkins Doris Duke Foundation Early Clinician Investigator Award (2017) Selected Participant2017 Leadership Program for Women Faculty, Johns Hopkins Medicine (2017) The Ryan Licht Sang Bipolar Foundation Research Award (2017) Best Manuscript by an Early Career Psychiatrist 2016Maryland Psychiatric Society (2016) Johns Hopkins Discovery Fund Innovation Award (2016) Invited Participant2014 Brain & Behavior Research Foundation National Awards Dinner (2014) Professional Associations/Affiliations Distinguished Fellow, American Psychiatric Association (2023) Elected Member, American College of Neuropsychopharmacology (2019) Member, Neural Basis of Psychopathology, Addictions and Sleep Disorders (NPAS) Study Section (2024) Member, Schizophrenia International Research Society (2019) Member, Society of Biological Psychiatry (2018)
