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Justin Rousseau, M.D.

Justin Rousseau, M.D.

Titles and Appointments

Deputy Chief Medical Informatics Officer for Neurosciences

Associate Professor

School
Medical School
Department
Neurology | Peter O'Donnell Jr. Brain Institute

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For more information on the doctor and patient care, please visit the clinical profile.

  • Biography

    Joined UT Southwestern: 2023

    Justin Rousseau, MD, MMSc, is an Associate Professor in the Department of Neurology and the Peter O’Donnell Jr. Brain Institute at UT Southwestern. He is a member of the Clinical Informatics Center, serves as Deputy Chief Medical Informatics Officer for Neurosciences, and is a member of the Informatics Core of the UT Southwestern Clinical Translational Science Award (CTSA) Program. He is board-certified in neurology and clinical informatics. 

    Research: Dr. Rousseau seeks to advance brain health research and care through the secondary use of electronic health record (EHR) data. His research and development interests to achieve this include developing and applying biomedical informatics methods including natural language processing (NLP), information extraction, standard ontologies and terminologies, computable phenotyping, and data warehousing to identify, harvest, and make accessible pertinent biomedical and health care data to support evidence-based clinical decisions, information sharing through transitions of care, and health research.

    Dr. Rousseau leads clinical research informatics efforts to collect, manage, analyze, and warehouse health data to support the development of learning health systems and clinical research networks. Example projects include: (1) the Early Psychosis Intervention Network of Texas (EPINET-TX); (2) the Texas Childhood Trauma Research Network (TX-CTRN), and (3) the Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study. During his time at Dell Medical School at UT Austin, Dr. Rousseau co-founded and co-directed the Data Core, which was adopted as part of Dell Medical School Enterprise Data Intelligence, a central resource for investigators accessing, managing, and analyzing clinical and non-clinical health-related data serving research and quality improvement activities through development of computable phenotypes to define patient cohorts, extraction of clinical data, and integration with other sources of data.

    Background: Built on foundational education in systems engineering, Dr. Rousseau obtained his medical degree from the University of Oklahoma Health Sciences Center. He completed his neurology residency at UC San Diego, where he was chief resident. He then completed an NIH National Library of Medicine fellowship and Master of Medical Sciences in Biomedical Informatics at Harvard Medical School and Brigham and Women’s Hospital with the Center for Evidence-based Imaging. He joined UT Southwestern after seven years with the Departments of Population Health and Neurology at Dell Medical School at UT Austin.

  • Education
    Medical School
    UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE (2010)
    Internship
    St. Mary Medical Center (2011), Internal Medicine
    Residency
    University of California San Diego (2014), Neurology
    Other Post Graduate Training
    Harvard Medical School (2016)
  • Research Interest
    • Biomedical Informatics
    • Clinical Informatics
    • Computable Phenotypes
    • Electronic Health Records
    • Natural Language Processing
    • Secondary Use of Electronic Health Records
  • Publications
    Exploring resource profiles among trauma exposed youth: An identity-focused, cultural, and person-centered approach
    Onyeka O, Cheng JS, Sanei S, Clark SL, Pinciotti CM, Guzick AG, Storch EA, Stewart SM, Sandoval JF, Taylor L, Riddle D, Garza C, Liberzon I, Rousseau J, Shahidullah JD, Newport DJ, Wagner KD, Nemeroff C Journal of affective disorders 2026 Jan 393
    Validity of the PHQ-9A as a self-report screener for major depressive disorder in youth ages 10–12 years
    Stewart SM, Sanei S, Abu-Samaha A, Emslie GJ, Rathouz PJ, Belford A, Garrett A, Shotwell J, Taylor LK, Rousseau JF, Shahidullah JD, Newport J, Wagner KD, Nemeroff CB Journal of affective disorders 2026 Jan 392
    History of interpersonal trauma exposure is a robust risk factor for alcohol and substance use disorders during adolescence
    Leri J, Cisler JM, Clark SL, Garrett A, Taylor L, Loganathan M, Trinh A, Shahidullah JD, Rousseau JF, Rathouz PJ, Newport DJ, Wagner KD, Nemeroff CB Journal of Psychiatric Research 2026 Jan 192 302-311
    Advancing delirium detection through the Open Health Natural Language Processing Consortium and the Evolve to Next-Gen Accrual to Clinical Trials Network
    Fu S, Kwak MJ, Ahn J, Yue Z, Ranganath S, Applegate JR, Wen A, Wang L, Li C, Morris M, Toth KM, Girard TD, Osborne JD, Kennedy RE, Garduno-Rapp NE, Reeder P, Rousseau JF, Yan C, Chen Y, Patel MB, Murphy TJ, Malin BA, Park CM, Jia H, Pagali S, Palmer AK, Sauver JS, Sohn S, Bernstam EV, Visweswaran S, Wang Y, Liu H Journals of Gerontology - Series A Biological Sciences and Medical Sciences 2025 Dec 80
    Dissecting clinical features of COVID-19 in a cohort of 21,312 acute care patients
    Maguire C, Soloveichik E, Blinchevsky N, Miller J, Morrison R, Busch J, Michael Brode W, Wylie D, Rousseau J, Melamed E Communications Medicine 2025 Dec 5
    Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS
    Author Collaboration IN, Author Collaboration CS, Costa Monteiro AC, Pickering H, Sarma A, Taylor CS, Jenkins MM, Hsu FM, Nadel B, Levy O, Baden LR, Melamed E, Ehrlich LI, McComsey GA, Sekaly RP, Cairns CB, Haddad EK, Shaw AC, Hafler DA, Montgomery RR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NI, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Geng LN, Fernandez-Sesma A, Simon V, Krammer F, Kraft M, Bime C, Calfee CS, Erle DJ, Bosinger S, Eckalbar W, Maecker H, Rahman A, Guan L, Peters B, Kleinstein SH, Augustine AD, Diray-Arce J, Becker PM, Rouphael N, Tipan PG, Rousseau JF Critical Care 2025 Dec 29
    SARS-CoV-2 humoral immune responses in convalescent individuals over 12 months reveal severity-dependent antibody dynamics
    Siles Alvarado N, Schuler M, Maguire C, Amengor DA, Nguyen AW, Wilen RE, Rogers J, Bazzi S, Caslin B, DiPasquale C, Abigania M, Olson E, Creaturo J, Hurley K, Triplett TA, Rousseau JF, Strakowski SM, Wylie D, Maynard JA, Ehrlich LI, Melamed E Communications Medicine 2025 Dec 5
    Leveraging long context in retrieval augmented language models for medical question answering
    Zhang G, Xu Z, Jin Q, Chen F, Fang Y, Liu Y, Rousseau JF, Xu Z, Lu Z, Weng C, Peng Y npj Digital Medicine 2025 Dec 8
    Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients
    Author Collaboration IN, Pickering H, Schaenman J, Phan HV, Maguire C, Tsitsiklis A, Rouphael N, Higuita NI, Atkinson MA, Brakenridge S, Fung M, Messer W, Seyfert-Margolis V, Rahman A, Wong K, Michelotti G, Hutton SR, Overton JA, Nagle C, Sheidy J, Schearer P, Ulring K, Mege N, Rogowski B, Tegos GP, McLin R, Furukawa S, Bell MR, Semenza NC, Croen B, Martens M, Smith CM, Simmons B, Goonewardene IM, Kim JN, Powell DL, Melnyk N, Lin E, Lee E, Edwards C, Joyner D, Woloszczuk K, Connors J, Cusimano G, Bernui M, Kutzler MA, Haddad EK, Cairns CB, Ribeiro SP, Tribout H, Rousseau JF Nature communications 2025 Dec 16
    Corrigendum to “Clinical characteristics and longitudinal associations with obsessive-compulsive disorder in youth exposed to trauma” [J Mood Anxiety Disord 10C (2025) 100117] (Journal of Mood and Anxiety Disorders (2025) 10, (S2950004425000148), (10.1016/j.xjmad.2025.100117))
    Pinciotti CM, Rathouz PJ, Guzick AG, Shahidullah JD, Bivins EJ, Riddle DB, Onyeka O“, Storch EA, Goodman WK, Franco K, Rousseau JF, Newport DJ, Wagner KD, Nemeroff CB Journal of Mood and Anxiety Disorders 2025 Dec 12