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Justin Rousseau, M.D.

Justin Rousseau, M.D.

Titles and Appointments

Deputy Chief Medical Informatics Officer for Neurosciences

Associate Professor

School
Medical School
Department
Neurology | Peter O'Donnell Jr. Brain Institute

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For more information on the doctor and patient care, please visit the clinical profile.

  • Biography

    Joined UT Southwestern: 2023

    Justin Rousseau, MD, MMSc, is an Associate Professor in the Department of Neurology and the Peter O’Donnell Jr. Brain Institute at UT Southwestern. He is a member of the Clinical Informatics Center, serves as Deputy Chief Medical Informatics Officer for Neurosciences, and is a member of the Informatics Core of the UT Southwestern Clinical Translational Science Award (CTSA) Program. He is board-certified in neurology and clinical informatics. 

    Research: Dr. Rousseau seeks to advance brain health research and care through the secondary use of electronic health record (EHR) data. His research and development interests to achieve this include developing and applying biomedical informatics methods including natural language processing (NLP), information extraction, standard ontologies and terminologies, computable phenotyping, and data warehousing to identify, harvest, and make accessible pertinent biomedical and health care data to support evidence-based clinical decisions, information sharing through transitions of care, and health research.

    Dr. Rousseau leads clinical research informatics efforts to collect, manage, analyze, and warehouse health data to support the development of learning health systems and clinical research networks. Example projects include: (1) the Early Psychosis Intervention Network of Texas (EPINET-TX); (2) the Texas Childhood Trauma Research Network (TX-CTRN), and (3) the Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study. During his time at Dell Medical School at UT Austin, Dr. Rousseau co-founded and co-directed the Data Core, which was adopted as part of Dell Medical School Enterprise Data Intelligence, a central resource for investigators accessing, managing, and analyzing clinical and non-clinical health-related data serving research and quality improvement activities through development of computable phenotypes to define patient cohorts, extraction of clinical data, and integration with other sources of data.

    Background: Built on foundational education in systems engineering, Dr. Rousseau obtained his medical degree from the University of Oklahoma Health Sciences Center. He completed his neurology residency at UC San Diego, where he was chief resident. He then completed an NIH National Library of Medicine fellowship and Master of Medical Sciences in Biomedical Informatics at Harvard Medical School and Brigham and Women’s Hospital with the Center for Evidence-based Imaging. He joined UT Southwestern after seven years with the Departments of Population Health and Neurology at Dell Medical School at UT Austin.

  • Education
    Medical School
    UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE (2010)
    Internship
    St. Mary Medical Center (2011), Internal Medicine
    Residency
    University of California San Diego (2014), Neurology
    Other Post Graduate Training
    Harvard Medical School (2016)
  • Research Interest
    • Biomedical Informatics
    • Clinical Informatics
    • Computable Phenotypes
    • Electronic Health Records
    • Natural Language Processing
    • Secondary Use of Electronic Health Records
  • Publications
    Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients
    Author Collaboration IN, Pickering H, Schaenman J, Phan HV, Maguire C, Tsitsiklis A, Rouphael N, Higuita NI, Atkinson MA, Brakenridge S, Fung M, Messer W, Seyfert-Margolis V, Rahman A, Wong K, Michelotti G, Hutton SR, Overton JA, Nagle C, Sheidy J, Schearer P, Ulring K, Mege N, Rogowski B, Tegos GP, McLin R, Furukawa S, Bell MR, Semenza NC, Croen B, Martens M, Smith CM, Simmons B, Goonewardene IM, Kim JN, Powell DL, Melnyk N, Lin E, Lee E, Edwards C, Joyner D, Woloszczuk K, Connors J, Cusimano G, Bernui M, Kutzler MA, Haddad EK, Cairns CB, Ribeiro SP, Tribout H, Rousseau JF Nature communications 2025 Dec 16
    Longitudinal Effects of Negative Ethnic-Racial Identity Affect on Internalizing Symptoms in Youth of Latiné Background Exposed to Interpersonal Trauma
    Stewart SM, Aksan N, Bancroft A, Shahidullah JD, Krantz SM, Guerra M, Sandoval J, Garza C, Viana AG, Morgan M, DeVargas C, Rousseau JF, Newport DJ, Wagner KD, Nemeroff CB The Journal of clinical psychiatry 2025 Mar 86
    Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke
    Rousseau JF, Weber JM, Alhanti B, Saver JL, Messé SR, Schwamm LH, Fonarow GC, Sheth KN, Smith EE, Mullen MT, Silva GS, Grory BM, Xian Y, Warach SJ JAMA Network Open 2025 Mar 8 e250548
    From GPT to DeepSeek: Significant gaps remain in realizing AI in healthcare
    Peng Y, Malin BA, Rousseau JF, Wang Y, Xu Z, Xu X, Weng C, Bian J Journal of Biomedical Informatics 2025 Mar 163
    Creating a collaborative culture of learning within a network of community mental health early psychosis programs in Texas
    Lopez MA, Reznik SJ, Klodnick VV, Cohen D, Myers N, Rousseau JF, Aksan N, de Oliveira E, Strakowski SM Schizophrenia Research 2025 Feb 276 1-7
    IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition
    Author Collaboration ID, Author Collaboration IS, Author Collaboration IC, Author Collaboration IC, Author Collaboration IN, Author Collaboration IS, Author Collaboration C&, Haslund-Gourley BS, Woloszczuk K, Hou J, Connors J, Cusimano G, Bell M, Taramangalam B, Fourati S, Mege N, Bernui M, Altman MC, Krammer F, van Bakel H, Maecker HT, Rouphael N, Diray-Arce J, Wigdah B, Kutzler MA, Cairns CB, Haddad EK, Comunale MA, Ozonoff A, Ehrlich LI, Melamed E, Sesma AF, Simon V, Pulendran B, Nadeau KC, Davis MM, McCoey GA, Sekaly R, Baden LR, Levy O, Schaenman J, Reed EF, Shaw AC, Hafler DA, Montgomery RR, Kleinstein SH, Becker PM, Augustine AD, Calfee CS, Erle DJ, Debakey ME, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Agudelo Higuita NI, Rousseau JF Nature communications 2024 Dec 15
    Hidden flaws behind expert-level accuracy of multimodal GPT-4 vision in medicine
    Jin Q, Chen F, Zhou Y, Xu Z, Cheung JM, Chen R, Summers RM, Rousseau JF, Ni P, Landsman MJ, Baxter SL, Al’Aref SJ, Li Y, Chen A, Brejt JA, Chiang MF, Peng Y, Lu Z npj Digital Medicine 2024 Dec 7
    Beyond bias: Aggregate approaches to conflicts of interest research and policy in biomedical research
    Graham SS, Harrison KR, Edward JC, Majdik ZP, Barbour JB, Rousseau JF World Medical and Health Policy 2024 Sep 16 489-505
    Patient Characteristics, Management, and Outcomes in a Novel Cohort of Primary Hyperparathyroidism
    Sant VR, Elnakieb Y, Lehmann C, Rousseau JF, Maalouf NM Journal of the Endocrine Society 2024 Aug 8
    Comparing diagnostic criteria for posttraumatic stress disorder in a diverse sample of trauma-exposed youth
    Dodd CG, Kirk CL, Rathouz PJ, Custer J, Garrett AS, Taylor L, Rousseau JF, Claasen C, Morgan MM, Newport DJ, Wagner KD, Nemeroff CB Journal of Traumatic Stress 2024 Aug 37 606-616