Leo Buckley, Pharm.D. Titles and Appointments Assistant Professor School Medical School Department Internal Medicine | Public Health Biography Leo F. Buckley, PharmD, MPH is a cardiovascular pharmacotherapy researcher and clinician whose work bridges molecular discovery with clinical implementation to improve heart failure prevention and treatment. He completed Pharmacy Practice and Cardiovascular Pharmacotherapy residencies at Brigham and Women's Hospital in his hometown Boston, MA, an Experimental Cardiovascular Pharmacotherapy fellowship at Virginia Commonwealth University and an MPH with a concentration in Clinical Effectiveness at Harvard TH Chan School of Public Health. Prior to joining the UT Southwestern faculty in 2025, he served as a Clinical Pharmacy Specialist and Clinical Investigator in the Department of Pharmacy at Brigham and Women's Hospital. His clinical research program integrates mechanistic clinical trials, epidemiology and advanced multi-omics (pharmaco-genomics/-proteomics/-metabolomics and single-cell analysis) to define how drugs modulate cardiac structure and function with the overall goal of developing novel, precision therapeutics for the prevention and treatment of heart failure. Current areas of emphasis include: defining the effects of iron repletion on cardiac structure, function, and energetics; elucidating molecular mechanisms of colchicine and anti-cytokine therapies; applying genomic, proteomic, metabolomic and single-cell analysis data to optimize cardiovascular drug interventions. Clinically, he practices in the Cardiomyopathy and Heart Failure Clinic, providing evidence-based pharmacotherapy for patients with complex cardiomyopathies. Research Interest Colchicine Epidemiology Genomics Iron Deficiency Metabolomics Pharmacogenomics Proteomics Single-Cell Analysis Publications Featured Publications Linking Chronic Kidney Disease to Incident Heart Failure and Adverse Cardiac Remodeling Through the Plasma Proteome: The Atherosclerosis Risk In Communities Study. Buckley LF, Dorbala P, Lamberson V, Claggett BL, Ren Y, Grams ME, Coresh J, Matsushita K, Demmer RT, Dubin RF, Deo R, Ganz P, Ballantyne CM, Hoogeveen RC, Yu B, Shah AM, JACC Heart Fail 2025 Jun 13 8 102512 Colchicine's Role in Cardiovascular Disease Management. Buckley LF, Libby P, Arterioscler Thromb Vasc Biol 2024 May 44 5 1031-1041 Circulating Neutrophil-Related Proteins Associate with Incident Heart Failure and Cardiac Dysfunction: The ARIC Study. Buckley LF, Dorbala P, Claggett BL, Libby P, Tang W, Coresh J, Ballantyne CM, Hoogeveen RC, Yu B, Shah AM, Eur J Heart Fail 2023 Aug Hepcidin, incident heart failure, and cardiac dysfunction in older adults: the ARIC study. Aboelsaad IAF, Claggett BL, Lamberson V, Dorbala P, Matsushita K, Lutsey P, Yu B, Lennep BW, Farag YMK, Shah AM, Buckley LF, Eur J Prev Cardiol 2025 Aug 32 11 993-1000 Potential Impact of Colchicine on Atherosclerotic Cardiovascular Disease in the United States. Buckley LF, Chebrolu B, Al Zaria M, Blankstein R, Libby P, Weber BN, JACC Adv 2025 Mar 4 3 101622 Absolute and Functional Iron Deficiency in the US, 2017-2020. Tawfik YMK, Billingsley H, Bhatt AS, Aboelsaad I, Al-Khezi OS, Lutsey PL, Buckley LF, JAMA Netw Open 2024 Sep 7 9 e2433126 Drug-Drug Interactions and the Clinical Tolerability of Colchicine Among Patients With COVID-19: A Secondary Analysis of the COLCORONA Randomized Clinical Trial. Alfehaid LS, Farah S, Omer A, Weber BN, Alkhezi O, Tawfik YMK, Shah AM, Libby P, Buckley LF, JAMA Netw Open 2024 Sep 7 9 e2431309 Plasma Ferritin Levels, Incident Heart Failure, and Cardiac Structure and Function: The ARIC Study. Aboelsaad IAF, Claggett BL, Arthur V, Dorbala P, Matsushita K, Lennep BW, Yu B, Lutsey PL, Ndumele CE, Farag YMK, Shah AM, Buckley LF, JACC Heart Fail 2023 Dec Chronic Kidney Disease, Heart Failure, and Adverse Cardiac Remodeling in Older Adults: The ARIC Study. Buckley LF, Claggett BL, Matsushita K, McMahon GM, Skali H, Coresh J, Folsom AR, Konety SH, Wagenknecht LE, Mosley TH, Shah AM, JACC Heart Fail 2023 May 11 5 523-537 Associations Between Kidney Histopathologic Lesions and Incident Cardiovascular Disease in Adults With Chronic Kidney Disease. Buckley LF, Schmidt IM, Verma A, Palsson R, Adam D, Shah AM, Srivastava A, Waikar SS, JAMA Cardiol 2023 Apr 8 4 357-365 Results 1-10 of 10 1
